Low CD4+ T-cell levels and B-cell apoptosis in vertically HIV-exposed noninfected children and adolescents

Maristela Miyamoto, Silvana D. Pessoa, Erika Ono, Daisy M. Machado, Reinaldo Salomão, Regina C.de M. Succi, Savita Pahwa, Maria Isabel de Moraes-Pinto

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Lymphocyte subsets, activation markers and apoptosis were assessed in 20 HIV-exposed noninfected (ENI) children born to HIV-infected women who were or not exposed to antiretroviral (ARV) drugs during pregnancy and early infancy. ENI children and adolescents were aged 6-18 years and they were compared to 25 age-matched healthy non-HIV-exposed children and adolescents (Control). ENI individuals presented lower CD4+ T cells/mm3 than Control group (control: 1120.3 vs. ENI: 876.3; t-test, p = 0.030). ENI individuals had higher B-cell apoptosis than Control group (Control: 36.6%, ARV exposed: 82.3%, ARV nonexposed: 68.5%; Kruskal-Wallis, p < 0.05), but no statistical difference was noticed between those exposed and not exposed to ARV. Immune activation in CD4+ T, CD8+ T and in B cells was comparable in ENI and in Control children and adolescents. Subtle long-term immune alterations might persist among ENI individuals, but the clinical consequences if any are unknown, and these children require continued monitoring.

Original languageEnglish (US)
Article numberfmq024
Pages (from-to)427-432
Number of pages6
JournalJournal of Tropical Pediatrics
Issue number6
StatePublished - Dec 2010


  • Antiretroviral agents
  • Apoptosis
  • B cell
  • CD4 T cell
  • Human immunodeficiency virus
  • Lymphocyte activation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases


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