Low CD4+ T-cell levels and B-cell apoptosis in vertically HIV-exposed noninfected children and adolescents

Maristela Miyamoto, Silvana D. Pessoa, Erika Ono, Daisy M. Machado, Reinaldo Salomão, Regina C.de M. Succi, Savita Pahwa, Maria Isabel de Moraes-Pinto

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Lymphocyte subsets, activation markers and apoptosis were assessed in 20 HIV-exposed noninfected (ENI) children born to HIV-infected women who were or not exposed to antiretroviral (ARV) drugs during pregnancy and early infancy. ENI children and adolescents were aged 6-18 years and they were compared to 25 age-matched healthy non-HIV-exposed children and adolescents (Control). ENI individuals presented lower CD4+ T cells/mm3 than Control group (control: 1120.3 vs. ENI: 876.3; t-test, p = 0.030). ENI individuals had higher B-cell apoptosis than Control group (Control: 36.6%, ARV exposed: 82.3%, ARV nonexposed: 68.5%; Kruskal-Wallis, p < 0.05), but no statistical difference was noticed between those exposed and not exposed to ARV. Immune activation in CD4+ T, CD8+ T and in B cells was comparable in ENI and in Control children and adolescents. Subtle long-term immune alterations might persist among ENI individuals, but the clinical consequences if any are unknown, and these children require continued monitoring.

Original languageEnglish (US)
Article numberfmq024
Pages (from-to)427-432
Number of pages6
JournalJournal of Tropical Pediatrics
Volume56
Issue number6
DOIs
StatePublished - Dec 2010

Keywords

  • Antiretroviral agents
  • Apoptosis
  • B cell
  • CD4 T cell
  • Human immunodeficiency virus
  • Lymphocyte activation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

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    Miyamoto, M., Pessoa, S. D., Ono, E., Machado, D. M., Salomão, R., Succi, R. C. D. M., Pahwa, S., & de Moraes-Pinto, M. I. (2010). Low CD4+ T-cell levels and B-cell apoptosis in vertically HIV-exposed noninfected children and adolescents. Journal of Tropical Pediatrics, 56(6), 427-432. [fmq024]. https://doi.org/10.1093/tropej/fmq024