TY - JOUR
T1 - Low birth weight and preterm births
T2 - Etiologic fraction attributable to prenatal drug exposure
AU - Bada, Henrietta S.
AU - Das, Abhik
AU - Bauer, Charles R.
AU - Shankaran, Seetha
AU - Lester, Barry M.
AU - Gard, Charlotte C.
AU - Wright, Linda L.
AU - LaGasse, Linda
AU - Higgins, Rosemary
N1 - Funding Information:
The study was carried out with support from NIH National Institute of Child Health and Human Development through cooperative agreements and interagency agreement with the National Institute on Drug Abuse (NIDA), Administration on Children, Youth and Families (ACYF), and Center for Substance Abuse Treatment (CSAT). Participating Institutions, grant awards, investigators, and key research personnel include: Brown University, U10 HD 27904, N01-HD-2-3159 (Barry M. Lester, PhD; Susan Schibler, RN; Melissa Ambrosia, RN; Linda LaGasse, PhD); University of Miami, U10 HD 21397 (Charles R. Bauer, MD; Wendy Griffin, RN; Elizabeth Jacque, RN); University of Tennessee, U10 HD 21415 (Henrietta S. Bada, MD; Marilyn Williams, MSW; Tina Hudson, BSN), Wayne State University, U10 HD 21385 (Seetha Shankaran, MD; Eunice Woldt, MSN, Jay Ann Nelson, BSN), RTI, International, U01 HD 36790 (W. Kenneth Poole, PhD; Abhik Das, PhD; Jane Hammond, PhD); NICHD (Linda L. Wright, MD; Rosemary Higgins, MD) and NIDA (Vincent L. Smeriglio, PhD).
PY - 2005/10
Y1 - 2005/10
N2 - Objectives: To determine the factors that would increase the likelihood of outcomes: low birth weight (LBW), preterm births and intrauterine growth restriction (IUGR). Study design: Secondary data analysis from a multi-center study. Risk factors for each outcome were derived from logistic regression models. Odds ratios (OR), 95% confidence intervals, and population-attributable risk proportions (PAR%) were estimated. Results: Prenatal cocaine exposure increased the likelihood of LBW (OR: 3.59), prematurity (OR: 1.25), and IUGR (OR: 2.24). Tobacco, but not marijuana, significantly influenced these outcomes. Alcohol had an effect on LBW and IUGR. Etiologic fractions (PAR%) attributable to tobacco for LBW, prematurity, and IUGR were 5.57, 3.66, and 13.79%, respectively. With additional drug exposure including cocaine, estimated summary PAR% increased to 7.20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). Conclusion: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine.
AB - Objectives: To determine the factors that would increase the likelihood of outcomes: low birth weight (LBW), preterm births and intrauterine growth restriction (IUGR). Study design: Secondary data analysis from a multi-center study. Risk factors for each outcome were derived from logistic regression models. Odds ratios (OR), 95% confidence intervals, and population-attributable risk proportions (PAR%) were estimated. Results: Prenatal cocaine exposure increased the likelihood of LBW (OR: 3.59), prematurity (OR: 1.25), and IUGR (OR: 2.24). Tobacco, but not marijuana, significantly influenced these outcomes. Alcohol had an effect on LBW and IUGR. Etiologic fractions (PAR%) attributable to tobacco for LBW, prematurity, and IUGR were 5.57, 3.66, and 13.79%, respectively. With additional drug exposure including cocaine, estimated summary PAR% increased to 7.20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). Conclusion: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine.
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U2 - 10.1038/sj.jp.7211378
DO - 10.1038/sj.jp.7211378
M3 - Article
C2 - 16107872
AN - SCOPUS:27144559644
VL - 25
SP - 631
EP - 637
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 10
ER -