Abstract
Objectives: To determine the factors that would increase the likelihood of outcomes: low birth weight (LBW), preterm births and intrauterine growth restriction (IUGR). Study design: Secondary data analysis from a multi-center study. Risk factors for each outcome were derived from logistic regression models. Odds ratios (OR), 95% confidence intervals, and population-attributable risk proportions (PAR%) were estimated. Results: Prenatal cocaine exposure increased the likelihood of LBW (OR: 3.59), prematurity (OR: 1.25), and IUGR (OR: 2.24). Tobacco, but not marijuana, significantly influenced these outcomes. Alcohol had an effect on LBW and IUGR. Etiologic fractions (PAR%) attributable to tobacco for LBW, prematurity, and IUGR were 5.57, 3.66, and 13.79%, respectively. With additional drug exposure including cocaine, estimated summary PAR% increased to 7.20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). Conclusion: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine.
| Original language | English |
|---|---|
| Pages (from-to) | 631-637 |
| Number of pages | 7 |
| Journal | Journal of Perinatology |
| Volume | 25 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2005 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
- Pediatrics, Perinatology, and Child Health
Cite this
Low birth weight and preterm births : Etiologic fraction attributable to prenatal drug exposure. / Bada, Henrietta S.; Das, Abhik; Bauer, Charles R; Shankaran, Seetha; Lester, Barry M.; Gard, Charlotte C.; Wright, Linda L.; LaGasse, Linda; Higgins, Rosemary.
In: Journal of Perinatology, Vol. 25, No. 10, 01.10.2005, p. 631-637.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low birth weight and preterm births
T2 - Etiologic fraction attributable to prenatal drug exposure
AU - Bada, Henrietta S.
AU - Das, Abhik
AU - Bauer, Charles R
AU - Shankaran, Seetha
AU - Lester, Barry M.
AU - Gard, Charlotte C.
AU - Wright, Linda L.
AU - LaGasse, Linda
AU - Higgins, Rosemary
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Objectives: To determine the factors that would increase the likelihood of outcomes: low birth weight (LBW), preterm births and intrauterine growth restriction (IUGR). Study design: Secondary data analysis from a multi-center study. Risk factors for each outcome were derived from logistic regression models. Odds ratios (OR), 95% confidence intervals, and population-attributable risk proportions (PAR%) were estimated. Results: Prenatal cocaine exposure increased the likelihood of LBW (OR: 3.59), prematurity (OR: 1.25), and IUGR (OR: 2.24). Tobacco, but not marijuana, significantly influenced these outcomes. Alcohol had an effect on LBW and IUGR. Etiologic fractions (PAR%) attributable to tobacco for LBW, prematurity, and IUGR were 5.57, 3.66, and 13.79%, respectively. With additional drug exposure including cocaine, estimated summary PAR% increased to 7.20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). Conclusion: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine.
AB - Objectives: To determine the factors that would increase the likelihood of outcomes: low birth weight (LBW), preterm births and intrauterine growth restriction (IUGR). Study design: Secondary data analysis from a multi-center study. Risk factors for each outcome were derived from logistic regression models. Odds ratios (OR), 95% confidence intervals, and population-attributable risk proportions (PAR%) were estimated. Results: Prenatal cocaine exposure increased the likelihood of LBW (OR: 3.59), prematurity (OR: 1.25), and IUGR (OR: 2.24). Tobacco, but not marijuana, significantly influenced these outcomes. Alcohol had an effect on LBW and IUGR. Etiologic fractions (PAR%) attributable to tobacco for LBW, prematurity, and IUGR were 5.57, 3.66, and 13.79%, respectively. With additional drug exposure including cocaine, estimated summary PAR% increased to 7.20% (LBW), 5.68% (prematurity), and 17.96% (IUGR). Conclusion: Disease burden for each outcome increases with each added drug exposure; however, etiologic fraction attributable to tobacco is greater than for cocaine.
UR - http://www.scopus.com/inward/record.url?scp=27144559644&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27144559644&partnerID=8YFLogxK
U2 - 10.1038/sj.jp.7211378
DO - 10.1038/sj.jp.7211378
M3 - Article
C2 - 16107872
AN - SCOPUS:27144559644
VL - 25
SP - 631
EP - 637
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 10
ER -