Losses of hemifield contrast sensitivity in patients with pituitary adenoma and normal visual acuity and visual field

V. Porciatti, P. Ciavarella, M. R. Ghiggi, V. D'Angelo, S. Padovano, M. Grifa, G. Moretti

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objective: To detect early losses of contrast sensitivity (CS) in patients with pituitary adenomas, before the occurrence of visual acuity and visual field defects. Methods: CS has been evaluated in both hemifields of 28 patients with different kinds of pituitary adenoma (mainly intrasellar) and normal visual acuity and visual field, as well as in 15 age-matched controls. Two different stimuli were used: a coarse (0.3 c/deg) dynamic (10 Hz) grating and a finer (2 c/deg) static grating. Results: On average, CS and/or hemifield asymmetry were reduced in patients, whereas perimetric sensitivity was normal. CS losses were more frequent for 2 c/deg static-, as compared with 0.3 c/deg, 10 Hz stimuli. However selective losses for either stimuli were also found. CS losses did not correlate with anatomical measurements (size, chiasm involvement) of tumors as established by MRI scans. Conclusions: CS evaluation may provide a simple and effective tool for early detection and monitoring of visual dysfunction in patients with pituitary adenoma. The lack of correlation between CS losses and chiasm involvement suggests causes different from chiasmal compression for visual dysfunction.

Original languageEnglish (US)
Pages (from-to)876-886
Number of pages11
JournalClinical Neurophysiology
Volume110
Issue number5
DOIs
StatePublished - May 1 1999
Externally publishedYes

Keywords

  • Contrast sensitivity
  • Magnocellular pathway
  • Parvocellular pathway
  • Pituitary adenoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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