Loss of reactivity of the pulmonary vascular bed in primary pulmonary hypertension

Philip Samet, William H. Bernstein

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Abstract

A follow-up case report of primary pulmonary hypertension is described. In 1959, intracardiac infusion of acetylcholine resulted in a considerable decrease in pulmonary arterial pressure both at rest and during exercise. In 1962, acetylcholine failed to elicit a decrement in pulmonary arterial pressure, demonstrating a loss of vasodilator reactivity of the pulmonary vascular bed over this period of time.

Original languageEnglish (US)
Pages (from-to)197-199
Number of pages3
JournalAmerican Heart Journal
Volume66
Issue number2
DOIs
StatePublished - Aug 1963

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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