A follow-up case report of primary pulmonary hypertension is described. In 1959, intracardiac infusion of acetylcholine resulted in a considerable decrease in pulmonary arterial pressure both at rest and during exercise. In 1962, acetylcholine failed to elicit a decrement in pulmonary arterial pressure, demonstrating a loss of vasodilator reactivity of the pulmonary vascular bed over this period of time.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine