Loss of reactivity of the pulmonary vascular bed in primary pulmonary hypertension

Philip Samet, William H. Bernstein

Research output: Contribution to journalArticle

10 Scopus citations


A follow-up case report of primary pulmonary hypertension is described. In 1959, intracardiac infusion of acetylcholine resulted in a considerable decrease in pulmonary arterial pressure both at rest and during exercise. In 1962, acetylcholine failed to elicit a decrement in pulmonary arterial pressure, demonstrating a loss of vasodilator reactivity of the pulmonary vascular bed over this period of time.

Original languageEnglish (US)
Pages (from-to)197-199
Number of pages3
JournalAmerican Heart Journal
Issue number2
StatePublished - Aug 1963


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this