Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation

Deborah C Mash, D. D. Flynn, L. T. Potter

Research output: Contribution to journalArticle

589 Citations (Scopus)

Abstract

Cerebral cortex samples from patients with Alzheimer's disease and from rats after experimental cholinergic denervation of the cerebral cortex exhibited reductions in the presynaptic marker choline acetyltransferase activity and in the number of M2 muscarine receptors, with no change in the number of M1 receptors. These results are in keeping with evidence that M2 receptors function in cholinergic nerve terminals to regulate the release of acetylcholine, whereas M1 receptors are located on postsynaptic cells and facilitate cellular excitation. New M1-selective agonists and M2-selective antagonists directed at post- or presynaptic sites deserve consideration as potential agents for the treatment of the disease.

Original languageEnglish
Pages (from-to)1115-1117
Number of pages3
JournalScience
Volume228
Issue number4703
StatePublished - Jan 1 1985

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Muscarine
Denervation
Cerebral Cortex
Cholinergic Agents
Alzheimer Disease
Choline O-Acetyltransferase
Acetylcholine
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. / Mash, Deborah C; Flynn, D. D.; Potter, L. T.

In: Science, Vol. 228, No. 4703, 01.01.1985, p. 1115-1117.

Research output: Contribution to journalArticle

Mash, Deborah C ; Flynn, D. D. ; Potter, L. T. / Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. In: Science. 1985 ; Vol. 228, No. 4703. pp. 1115-1117.
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