Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers

F. Leduc, H. Brauch, C. Hajj, A. Dobrovic, F. Kaye, A. Gazdar, J. William Harbour, O. S. Pettengill, G. D. Sorenson, A. Van Den Berg, K. Kok, B. Campling, F. Paquin, W. E C Bradley, B. Zbar, J. Minna, C. Buys, J. Ayoub

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Abstract

The ERBAβ gene codes for a DNA-binding thyroid hormone receptor (THR) and maps to chromosome 3p21-p25, overlapping a 3p deletion characterizing small-cell lung carcinoma (SCLC). A DNA clone detecting an RFLP at the ERBAβ locus has been used to probe a large number of lung tumors. Virtually all SCLC had lost heterozygosity, showing that the 3p deletion in SCLC includes this gene. A substantial but smaller proportion of non-small-cell carcinomas had lost heterozygosity at ERBAβ. Among all non-small-cell tumors some had lost heterozygosity at the proximal locus DFN15S2 (band 3p21) but not at ERBAβ, whereas none were found where the reverse was true. Therefore, the locus which plays a role in non-small-cell tumorigenesis probably lies closer to DNF15S2 than to ERBAβ and is almost certainly not the latter.

Original languageEnglish
Pages (from-to)282-287
Number of pages6
JournalAmerican Journal of Human Genetics
Volume44
Issue number2
StatePublished - Jan 1 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Leduc, F., Brauch, H., Hajj, C., Dobrovic, A., Kaye, F., Gazdar, A., William Harbour, J., Pettengill, O. S., Sorenson, G. D., Van Den Berg, A., Kok, K., Campling, B., Paquin, F., Bradley, W. E. C., Zbar, B., Minna, J., Buys, C., & Ayoub, J. (1989). Loss of heterozygosity in a gene coding for a thyroid hormone receptor in lung cancers. American Journal of Human Genetics, 44(2), 282-287.