Longterm infrared neural stimulation in the chronic implanted cat

Agnella Izzo Matic, Alan M. Robinson, Hunter K. Young, Ben Badofsky, Suhrud M Rajguru, Claus Peter Richter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Among neural prostheses cochlear implants (CIs) are considered the most successful devices. They restore some hearing to ∼210,000 severe-to-profound hearing impaired people. Despite the devices' success, the performance of the implanted individuals in noisy environments is poor and music perception is rudimentary. It has been argued that increasing the number of independent channels for stimulation can improve the performance of a CI user in challenging hearing environments. An optical method, stimulating neurons with infrared radiation, has been suggested as a novel approach to increase the number of independent channels. Infrared neural stimulation (INS) works through the deposition of heat into the tissue. Thermal damage is therefore a potential risk, particularly for longterm exposure. To verify the efficacy and safety of INS, cats were implanted for about 4 weeks and were continuously stimulated daily for 6-8 hours. Cochlear function did not change during the stimulation, and histology did not reveal signs of damage. Tissue growth following the implantation was largely localized at the cochleostomy.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8565
DOIs
StatePublished - May 30 2013
EventPhotonic Therapeutics and Diagnostics IX - San Francisco, CA, United States
Duration: Feb 2 2013Feb 7 2013

Other

OtherPhotonic Therapeutics and Diagnostics IX
CountryUnited States
CitySan Francisco, CA
Period2/2/132/7/13

Fingerprint

cats
Audition
stimulation
Cochlear implants
Hearing
Cats
Cochlear Implants
hearing
Infrared radiation
Neural Prostheses
Hot Temperature
Neural prostheses
Tissue
Equipment and Supplies
Histology
Cochlea
Music
damage
Neurons
Prostheses and Implants

Keywords

  • Cat
  • Chronic implantation
  • Infrared neural stimulation
  • Laser

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Matic, A. I., Robinson, A. M., Young, H. K., Badofsky, B., Rajguru, S. M., & Richter, C. P. (2013). Longterm infrared neural stimulation in the chronic implanted cat. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8565). [85655T] https://doi.org/10.1117/12.2013851

Longterm infrared neural stimulation in the chronic implanted cat. / Matic, Agnella Izzo; Robinson, Alan M.; Young, Hunter K.; Badofsky, Ben; Rajguru, Suhrud M; Richter, Claus Peter.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565 2013. 85655T.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Matic, AI, Robinson, AM, Young, HK, Badofsky, B, Rajguru, SM & Richter, CP 2013, Longterm infrared neural stimulation in the chronic implanted cat. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8565, 85655T, Photonic Therapeutics and Diagnostics IX, San Francisco, CA, United States, 2/2/13. https://doi.org/10.1117/12.2013851
Matic AI, Robinson AM, Young HK, Badofsky B, Rajguru SM, Richter CP. Longterm infrared neural stimulation in the chronic implanted cat. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565. 2013. 85655T https://doi.org/10.1117/12.2013851
Matic, Agnella Izzo ; Robinson, Alan M. ; Young, Hunter K. ; Badofsky, Ben ; Rajguru, Suhrud M ; Richter, Claus Peter. / Longterm infrared neural stimulation in the chronic implanted cat. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8565 2013.
@inproceedings{63f00018c6f94f709cb86d284e328d36,
title = "Longterm infrared neural stimulation in the chronic implanted cat",
abstract = "Among neural prostheses cochlear implants (CIs) are considered the most successful devices. They restore some hearing to ∼210,000 severe-to-profound hearing impaired people. Despite the devices' success, the performance of the implanted individuals in noisy environments is poor and music perception is rudimentary. It has been argued that increasing the number of independent channels for stimulation can improve the performance of a CI user in challenging hearing environments. An optical method, stimulating neurons with infrared radiation, has been suggested as a novel approach to increase the number of independent channels. Infrared neural stimulation (INS) works through the deposition of heat into the tissue. Thermal damage is therefore a potential risk, particularly for longterm exposure. To verify the efficacy and safety of INS, cats were implanted for about 4 weeks and were continuously stimulated daily for 6-8 hours. Cochlear function did not change during the stimulation, and histology did not reveal signs of damage. Tissue growth following the implantation was largely localized at the cochleostomy.",
keywords = "Cat, Chronic implantation, Infrared neural stimulation, Laser",
author = "Matic, {Agnella Izzo} and Robinson, {Alan M.} and Young, {Hunter K.} and Ben Badofsky and Rajguru, {Suhrud M} and Richter, {Claus Peter}",
year = "2013",
month = "5",
day = "30",
doi = "10.1117/12.2013851",
language = "English",
isbn = "9780819493347",
volume = "8565",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

}

TY - GEN

T1 - Longterm infrared neural stimulation in the chronic implanted cat

AU - Matic, Agnella Izzo

AU - Robinson, Alan M.

AU - Young, Hunter K.

AU - Badofsky, Ben

AU - Rajguru, Suhrud M

AU - Richter, Claus Peter

PY - 2013/5/30

Y1 - 2013/5/30

N2 - Among neural prostheses cochlear implants (CIs) are considered the most successful devices. They restore some hearing to ∼210,000 severe-to-profound hearing impaired people. Despite the devices' success, the performance of the implanted individuals in noisy environments is poor and music perception is rudimentary. It has been argued that increasing the number of independent channels for stimulation can improve the performance of a CI user in challenging hearing environments. An optical method, stimulating neurons with infrared radiation, has been suggested as a novel approach to increase the number of independent channels. Infrared neural stimulation (INS) works through the deposition of heat into the tissue. Thermal damage is therefore a potential risk, particularly for longterm exposure. To verify the efficacy and safety of INS, cats were implanted for about 4 weeks and were continuously stimulated daily for 6-8 hours. Cochlear function did not change during the stimulation, and histology did not reveal signs of damage. Tissue growth following the implantation was largely localized at the cochleostomy.

AB - Among neural prostheses cochlear implants (CIs) are considered the most successful devices. They restore some hearing to ∼210,000 severe-to-profound hearing impaired people. Despite the devices' success, the performance of the implanted individuals in noisy environments is poor and music perception is rudimentary. It has been argued that increasing the number of independent channels for stimulation can improve the performance of a CI user in challenging hearing environments. An optical method, stimulating neurons with infrared radiation, has been suggested as a novel approach to increase the number of independent channels. Infrared neural stimulation (INS) works through the deposition of heat into the tissue. Thermal damage is therefore a potential risk, particularly for longterm exposure. To verify the efficacy and safety of INS, cats were implanted for about 4 weeks and were continuously stimulated daily for 6-8 hours. Cochlear function did not change during the stimulation, and histology did not reveal signs of damage. Tissue growth following the implantation was largely localized at the cochleostomy.

KW - Cat

KW - Chronic implantation

KW - Infrared neural stimulation

KW - Laser

UR - http://www.scopus.com/inward/record.url?scp=84878204405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878204405&partnerID=8YFLogxK

U2 - 10.1117/12.2013851

DO - 10.1117/12.2013851

M3 - Conference contribution

SN - 9780819493347

VL - 8565

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

ER -