Longitudinal study of falls among HIV-infected and uninfected women: The role of cognition

Anjali Sharma, Donald R. Hoover, Qiuhu Shi, Susan Holman, Michael W. Plankey, Phyllis C. Tien, Kathleen M. Weber, Michelle Floris-Moore, Hector Bolivar, David E. Vance, Elizabeth T. Golub, Marcia McDonnell Holstad, Michael T. Yin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Although fracture rates are higher in HIV+ HIV- women, including ≥2 falls in 25% HIV+ and 24% HIV-than HIV- women, whether HIV infection increases risk (overall P=0.30). Cognitive complaints were associated of falls is unclear. We determined the longitudinal occur-with falls among HIV+ (odds ratio [OR] 2.38; 95% CI 1.83, rence and risk factors for falls in the Women’s Intera-3.09) and HIV- women (OR 3.43; 95% CI 2.37, 4.97); in gency HIV Study (WIHS), and explored associations with adjusted models, cognitive complaints remained significant cognitive complaints. only in HIV- women (adjusted [aOR] 2.26; 95% CI 1.46, Methods: Recent (prior 6 months) self-reported falls were 3.48). Factors associated with any fall in adjusted analyses collected in 1,816 (1,250 HIV+; 566 HIV-) women over included: depressive symptoms and neuropathy (both HIV+ 24 months. Generalized estimating equation models using and HIV-); age, marijuana use, multiple CNS medications, stepwise selection determined odds of any fall (versus and HCV infection (HIV+ only); and cognitive complaints, none). quality of life, hypertension and obesity (HIV- only). Results: HIV+ women were older than HIV- women Conclusions: Middle-aged HIV+ and HIV- women had (median 49 versus 47 years; P=0.0004), more likely to similar fall rates. Among HIV+ women, factors affecting report neuropathy (20% versus 16%; P=0.023), and had cognition such as age, depressive symptoms, marijuana greater central nervous system (CNS) medication use. use and multiple CNS medications were important predic-At least one fall was reported in 41% HIV+ versus 42% tors of falls, however, cognitive complaints were not.

Original languageEnglish (US)
Pages (from-to)179-190
Number of pages12
JournalAntiviral Therapy
Volume23
Issue number2
DOIs
StatePublished - Jan 1 2018

Fingerprint

Cognition
Longitudinal Studies
HIV
Central Nervous System
Cannabis
HIV Infections
Odds Ratio
Depression

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Sharma, A., Hoover, D. R., Shi, Q., Holman, S., Plankey, M. W., Tien, P. C., ... Yin, M. T. (2018). Longitudinal study of falls among HIV-infected and uninfected women: The role of cognition. Antiviral Therapy, 23(2), 179-190. https://doi.org/10.3851/IMP3195

Longitudinal study of falls among HIV-infected and uninfected women : The role of cognition. / Sharma, Anjali; Hoover, Donald R.; Shi, Qiuhu; Holman, Susan; Plankey, Michael W.; Tien, Phyllis C.; Weber, Kathleen M.; Floris-Moore, Michelle; Bolivar, Hector; Vance, David E.; Golub, Elizabeth T.; McDonnell Holstad, Marcia; Yin, Michael T.

In: Antiviral Therapy, Vol. 23, No. 2, 01.01.2018, p. 179-190.

Research output: Contribution to journalArticle

Sharma, A, Hoover, DR, Shi, Q, Holman, S, Plankey, MW, Tien, PC, Weber, KM, Floris-Moore, M, Bolivar, H, Vance, DE, Golub, ET, McDonnell Holstad, M & Yin, MT 2018, 'Longitudinal study of falls among HIV-infected and uninfected women: The role of cognition', Antiviral Therapy, vol. 23, no. 2, pp. 179-190. https://doi.org/10.3851/IMP3195
Sharma A, Hoover DR, Shi Q, Holman S, Plankey MW, Tien PC et al. Longitudinal study of falls among HIV-infected and uninfected women: The role of cognition. Antiviral Therapy. 2018 Jan 1;23(2):179-190. https://doi.org/10.3851/IMP3195
Sharma, Anjali ; Hoover, Donald R. ; Shi, Qiuhu ; Holman, Susan ; Plankey, Michael W. ; Tien, Phyllis C. ; Weber, Kathleen M. ; Floris-Moore, Michelle ; Bolivar, Hector ; Vance, David E. ; Golub, Elizabeth T. ; McDonnell Holstad, Marcia ; Yin, Michael T. / Longitudinal study of falls among HIV-infected and uninfected women : The role of cognition. In: Antiviral Therapy. 2018 ; Vol. 23, No. 2. pp. 179-190.
@article{6f4078dcb38e4ac88c01ce1504ed53ae,
title = "Longitudinal study of falls among HIV-infected and uninfected women: The role of cognition",
abstract = "Background: Although fracture rates are higher in HIV+ HIV- women, including ≥2 falls in 25{\%} HIV+ and 24{\%} HIV-than HIV- women, whether HIV infection increases risk (overall P=0.30). Cognitive complaints were associated of falls is unclear. We determined the longitudinal occur-with falls among HIV+ (odds ratio [OR] 2.38; 95{\%} CI 1.83, rence and risk factors for falls in the Women’s Intera-3.09) and HIV- women (OR 3.43; 95{\%} CI 2.37, 4.97); in gency HIV Study (WIHS), and explored associations with adjusted models, cognitive complaints remained significant cognitive complaints. only in HIV- women (adjusted [aOR] 2.26; 95{\%} CI 1.46, Methods: Recent (prior 6 months) self-reported falls were 3.48). Factors associated with any fall in adjusted analyses collected in 1,816 (1,250 HIV+; 566 HIV-) women over included: depressive symptoms and neuropathy (both HIV+ 24 months. Generalized estimating equation models using and HIV-); age, marijuana use, multiple CNS medications, stepwise selection determined odds of any fall (versus and HCV infection (HIV+ only); and cognitive complaints, none). quality of life, hypertension and obesity (HIV- only). Results: HIV+ women were older than HIV- women Conclusions: Middle-aged HIV+ and HIV- women had (median 49 versus 47 years; P=0.0004), more likely to similar fall rates. Among HIV+ women, factors affecting report neuropathy (20{\%} versus 16{\%}; P=0.023), and had cognition such as age, depressive symptoms, marijuana greater central nervous system (CNS) medication use. use and multiple CNS medications were important predic-At least one fall was reported in 41{\%} HIV+ versus 42{\%} tors of falls, however, cognitive complaints were not.",
author = "Anjali Sharma and Hoover, {Donald R.} and Qiuhu Shi and Susan Holman and Plankey, {Michael W.} and Tien, {Phyllis C.} and Weber, {Kathleen M.} and Michelle Floris-Moore and Hector Bolivar and Vance, {David E.} and Golub, {Elizabeth T.} and {McDonnell Holstad}, Marcia and Yin, {Michael T.}",
year = "2018",
month = "1",
day = "1",
doi = "10.3851/IMP3195",
language = "English (US)",
volume = "23",
pages = "179--190",
journal = "Antiviral Therapy",
issn = "1359-6535",
publisher = "International Medical Press Ltd",
number = "2",

}

TY - JOUR

T1 - Longitudinal study of falls among HIV-infected and uninfected women

T2 - The role of cognition

AU - Sharma, Anjali

AU - Hoover, Donald R.

AU - Shi, Qiuhu

AU - Holman, Susan

AU - Plankey, Michael W.

AU - Tien, Phyllis C.

AU - Weber, Kathleen M.

AU - Floris-Moore, Michelle

AU - Bolivar, Hector

AU - Vance, David E.

AU - Golub, Elizabeth T.

AU - McDonnell Holstad, Marcia

AU - Yin, Michael T.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Although fracture rates are higher in HIV+ HIV- women, including ≥2 falls in 25% HIV+ and 24% HIV-than HIV- women, whether HIV infection increases risk (overall P=0.30). Cognitive complaints were associated of falls is unclear. We determined the longitudinal occur-with falls among HIV+ (odds ratio [OR] 2.38; 95% CI 1.83, rence and risk factors for falls in the Women’s Intera-3.09) and HIV- women (OR 3.43; 95% CI 2.37, 4.97); in gency HIV Study (WIHS), and explored associations with adjusted models, cognitive complaints remained significant cognitive complaints. only in HIV- women (adjusted [aOR] 2.26; 95% CI 1.46, Methods: Recent (prior 6 months) self-reported falls were 3.48). Factors associated with any fall in adjusted analyses collected in 1,816 (1,250 HIV+; 566 HIV-) women over included: depressive symptoms and neuropathy (both HIV+ 24 months. Generalized estimating equation models using and HIV-); age, marijuana use, multiple CNS medications, stepwise selection determined odds of any fall (versus and HCV infection (HIV+ only); and cognitive complaints, none). quality of life, hypertension and obesity (HIV- only). Results: HIV+ women were older than HIV- women Conclusions: Middle-aged HIV+ and HIV- women had (median 49 versus 47 years; P=0.0004), more likely to similar fall rates. Among HIV+ women, factors affecting report neuropathy (20% versus 16%; P=0.023), and had cognition such as age, depressive symptoms, marijuana greater central nervous system (CNS) medication use. use and multiple CNS medications were important predic-At least one fall was reported in 41% HIV+ versus 42% tors of falls, however, cognitive complaints were not.

AB - Background: Although fracture rates are higher in HIV+ HIV- women, including ≥2 falls in 25% HIV+ and 24% HIV-than HIV- women, whether HIV infection increases risk (overall P=0.30). Cognitive complaints were associated of falls is unclear. We determined the longitudinal occur-with falls among HIV+ (odds ratio [OR] 2.38; 95% CI 1.83, rence and risk factors for falls in the Women’s Intera-3.09) and HIV- women (OR 3.43; 95% CI 2.37, 4.97); in gency HIV Study (WIHS), and explored associations with adjusted models, cognitive complaints remained significant cognitive complaints. only in HIV- women (adjusted [aOR] 2.26; 95% CI 1.46, Methods: Recent (prior 6 months) self-reported falls were 3.48). Factors associated with any fall in adjusted analyses collected in 1,816 (1,250 HIV+; 566 HIV-) women over included: depressive symptoms and neuropathy (both HIV+ 24 months. Generalized estimating equation models using and HIV-); age, marijuana use, multiple CNS medications, stepwise selection determined odds of any fall (versus and HCV infection (HIV+ only); and cognitive complaints, none). quality of life, hypertension and obesity (HIV- only). Results: HIV+ women were older than HIV- women Conclusions: Middle-aged HIV+ and HIV- women had (median 49 versus 47 years; P=0.0004), more likely to similar fall rates. Among HIV+ women, factors affecting report neuropathy (20% versus 16%; P=0.023), and had cognition such as age, depressive symptoms, marijuana greater central nervous system (CNS) medication use. use and multiple CNS medications were important predic-At least one fall was reported in 41% HIV+ versus 42% tors of falls, however, cognitive complaints were not.

UR - http://www.scopus.com/inward/record.url?scp=85047180363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047180363&partnerID=8YFLogxK

U2 - 10.3851/IMP3195

DO - 10.3851/IMP3195

M3 - Article

C2 - 28933703

AN - SCOPUS:85047180363

VL - 23

SP - 179

EP - 190

JO - Antiviral Therapy

JF - Antiviral Therapy

SN - 1359-6535

IS - 2

ER -