Longitudinal examination of fellow-eye vascular anomalies in coats’ disease with widefield fluorescein angiography: A multicenter study

Karen W. Jeng-Miller, Taha Soomro, Nathan L. Scott, Prethy Rao, Elizabeth Marlow, Emmanuel Y. Chang, Anna Ells, Felix Chau, Eric Nudleman, Charles M. Calvo, Nish Patel, Roy Schwartz, Linda A. Cernichiaro-Espinosa, Alexandrea Gabrielle Montoya, Jessica Goldstein, C. Armitage Harper, Caroline R. Baumal, Mary Elizabeth Hartnett, J. William Harbour, Cagri G. BesirliMrinali P. Gupta, R. V.Paul Chan, Kimberly A. Drenser, Antonio Capone, Timothy G. Murray, Shizuo Mukai, Michael T. Trese, Audina M. Berrocal, Sui Chien Wong, Yoshihiro Yonekawa

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND OBJECTIVE: Retinovascular anomalies in the fellow eyes of patients with Coats’ disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time. PATIENTS AND METHODS: This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats’ disease. RESULTS: Three hundred fifty eyes of 175 patients with Coats’ disease were analyzed. A total of 33 patients (18.8%) demonstrated abnormal fellow-eye findings: 14 (42.4%) telangiectasias, 18 (54.5%) aneurysms, six (18.2%) segmental non-perfusion, six (18.2%) leakage, and two (6.0%) vascular tortuosity. All eyes were asymptomatic, and none of the lesions progressed over time. There was no association between fellow-eye findings with severity of Coats’ disease (P = .16), patient age (P = .16), or presence of systemic vascular disease (P = .16). CONCLUSIONS: The vascular abnormalities in fellow eyes of patients with Coats’ disease did not progress over time. Observation is a reasonable initial management strategy.

Original languageEnglish (US)
Pages (from-to)221-227
Number of pages7
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume50
Issue number4
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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    Jeng-Miller, K. W., Soomro, T., Scott, N. L., Rao, P., Marlow, E., Chang, E. Y., Ells, A., Chau, F., Nudleman, E., Calvo, C. M., Patel, N., Schwartz, R., Cernichiaro-Espinosa, L. A., Montoya, A. G., Goldstein, J., Harper, C. A., Baumal, C. R., Hartnett, M. E., Harbour, J. W., ... Yonekawa, Y. (2019). Longitudinal examination of fellow-eye vascular anomalies in coats’ disease with widefield fluorescein angiography: A multicenter study. Ophthalmic Surgery Lasers and Imaging Retina, 50(4), 221-227. https://doi.org/10.3928/23258160-20190401-04