Longitudinal computational fluid dynamics study of aneurysmal dilatation in a chronic DeBakey type III aortic dissection

Christof Karmonik, Sasan Partovi, Matthias Müller-Eschner, Jean Bismuth, Mark G. Davies, Dipan J. Shah, Matthias Loebe, Dittmar Böckler, Alan B. Lumsden, Hendrik Von Tengg-Kobligk

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Computational fluid dynamics, which uses numeric methods and algorithms for the simulation of blood flow by solving the Navier-Stokes equations on computational meshes, is enhancing the understanding of disease progression in type III aortic dissections. To illustrate this, we examined the changes in patient-derived geometries of aortic dissections, which showed progressive false lumen aneurysmal dilatation (26% diameter increase) during follow-up. Total pressure was decreased by 29% during systole and by 34% during retrograde flow. At the site of the highest false lumen dilatation, the temporal average of total pressure decreased from 45 to 22 Pa, and maximal average wall shear stress decreased from 0.9 to 0.4 Pa. These first results in the study of disease progression of type III DeBakey aortic dissection with computational fluid dynamics are encouraging.

Original languageEnglish (US)
JournalJournal of Vascular Surgery
Volume56
Issue number1
DOIs
StatePublished - Jul 2012
Externally publishedYes

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Hydrodynamics
Dissection
Dilatation
Disease Progression
Pressure
Systole

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Karmonik, C., Partovi, S., Müller-Eschner, M., Bismuth, J., Davies, M. G., Shah, D. J., ... Von Tengg-Kobligk, H. (2012). Longitudinal computational fluid dynamics study of aneurysmal dilatation in a chronic DeBakey type III aortic dissection. Journal of Vascular Surgery, 56(1). https://doi.org/10.1016/j.jvs.2012.02.064

Longitudinal computational fluid dynamics study of aneurysmal dilatation in a chronic DeBakey type III aortic dissection. / Karmonik, Christof; Partovi, Sasan; Müller-Eschner, Matthias; Bismuth, Jean; Davies, Mark G.; Shah, Dipan J.; Loebe, Matthias; Böckler, Dittmar; Lumsden, Alan B.; Von Tengg-Kobligk, Hendrik.

In: Journal of Vascular Surgery, Vol. 56, No. 1, 07.2012.

Research output: Contribution to journalArticle

Karmonik, C, Partovi, S, Müller-Eschner, M, Bismuth, J, Davies, MG, Shah, DJ, Loebe, M, Böckler, D, Lumsden, AB & Von Tengg-Kobligk, H 2012, 'Longitudinal computational fluid dynamics study of aneurysmal dilatation in a chronic DeBakey type III aortic dissection', Journal of Vascular Surgery, vol. 56, no. 1. https://doi.org/10.1016/j.jvs.2012.02.064
Karmonik, Christof ; Partovi, Sasan ; Müller-Eschner, Matthias ; Bismuth, Jean ; Davies, Mark G. ; Shah, Dipan J. ; Loebe, Matthias ; Böckler, Dittmar ; Lumsden, Alan B. ; Von Tengg-Kobligk, Hendrik. / Longitudinal computational fluid dynamics study of aneurysmal dilatation in a chronic DeBakey type III aortic dissection. In: Journal of Vascular Surgery. 2012 ; Vol. 56, No. 1.
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