LONGITUDINAL ANALYSIS OF DIABETIC CHOROIDOPATHY IN PROLIFERATIVE DIABETIC RETINOPATHY TREATED WITH PANRETINAL PHOTOCOAGULATION USING WIDEFIELD SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY

Jonathan F. Russell, Hao Zhou, Yingying Shi, Mengxi Shen, Giovanni Gregori, William J. Feuer, Ruikang K. Wang, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Widefield swept-source optical coherence tomography (OCT) imaging was used to characterize choroidal thickness and vascularity at baseline in proliferative diabetic retinopathy (PDR) and longitudinally after panretinal photocoagulation (PRP). Methods: Patients with treatment-naive PDR were imaged at baseline and at 1 week, 1 month, and 3 months after PRP. Previously validated algorithms were used to calculate the mean choroidal thickness (MCT) and choroidal vascularity index (CVI) in 5 regions of 12 mm · 12 mm scans. Results: Fourteen PDR eyes were included. Baseline MCT in PDR eyes did not differ significantly from normal eyes, but CVI measurements in PDR eyes were lower in all regions (P< 0.001-0.008). After PRP, MCT measurements in PDR eyes were significantly lower at 1 month and 3 months in all regions (P< 0.001-0.005) except the fovea (P = 0.074). However, CVI measurements did not change over time in any region after PRP. Conclusion: The choroid in PDR eyes has a smaller CVI than that in normal eyes. After PRP, the choroidal thickness decreases outside the fovea, but the CVI remains constant, which suggests that a relative decrease in choroidal vascularity persists. These widefield swept-source OCT results are consistent with choroidal alterations found in histopathological reports of diabetic choroidopathy.

Original languageEnglish (US)
Pages (from-to)417-425
Number of pages9
JournalRetina
Volume42
Issue number3
DOIs
StatePublished - Mar 1 2022
Externally publishedYes

Keywords

  • Choroidal thickness
  • Choroidal vascularity
  • Diabetic choroidopathy
  • Diabetic retinopathy
  • Panretinal photocoagulation
  • Swept-source OCT

ASJC Scopus subject areas

  • Ophthalmology

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