Long-term survivors of kidney transplantation, mortality, rehabilitation, and immunologic reactivities.

H. M. Lee, N. Kenyon, G. Mendez-Picon, M. P. Posner

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

1. The overall patient and graft survival rates (83.6% and 82% respectively) up to 23 years posttransplant of the group who survived a minimum of 10 years is reasonably good regardless of the donor source. 2. The primary grafts that survived a minimum of 10 years and were lost during the subsequent 12 years (17.7%) were equally due to rejection and the death of the patient. 3. Rehabilitation of the long-term survivor has been very good. Cardiovascular disease is becoming a significant morbidity among pediatric-aged recipients reaching the thirties. 4. The causes of death after 10-year survival are evenly distributed among infection, cardiovascular disease, neoplasms, dialysis, and hepatic failure. 5. The selected studies of immunologic reactivities in the long-term survivors show their failure to generate significant killing against donor-specific antigens while displaying normal MLR response against donor and third party. Significant depressions in their ability to respond in vitro to soluble antigens was also demonstrated.

Original languageEnglish (US)
Pages (from-to)2120-2121
Number of pages2
JournalTransplantation proceedings
Volume19
Issue number1 Pt 3
StatePublished - Feb 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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