The present study was made possible by the development of a procedure to isolate islets from a single canine pancreas in sufficient quantities and prurity to provide autoengraftment after portal vein injection in totally pancreatectomized beagle dogs. The refinement of the technique with islet autografts has prompted this report of the immunosuppressive effectiveness of cyclosporine A (CsA) with islet allografts. We also asked whether interruption of CsA administration would still be associated with long-term allograft acceptance as previously shown in rodents and rabbits.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Jan 1 1986|
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