Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome

Erin A. Doe, Donald L. Budenz, Steven J Gedde, Nauman R. Imami

Research output: Contribution to journalArticle

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Abstract

Purpose: To report the long-term outcomes of patients with iridocorneal endothelial (ICE) syndrome who required surgery for glaucoma. Design: Retrospective, noncomparative case series. Participants: Twenty-six patients with ICE syndrome who underwent surgery for glaucoma at one institution between January 1987 and January 2000. Main Outcome Measures: Intraocular pressure (IOP), visual acuity, number of glaucoma medications, and further surgical interventions were measured. Results: Five eyes had a trabeculectomy with an antifibrotic agent alone, seven eyes had a trabeculectomy with an antifibrotic agent and a subsequent glaucoma drainage implant (GDI), and 14 eyes had a GDI alone. In eyes that underwent a trabeculectomy with an antifibrotic agent, preoperative IOP was reduced from a mean of 38.8 ± 10.5 mmHg on 2.3 ± 0.8 glaucoma medications to a mean of 11.8 ± 4.3 mmHg on 1.2 ± 1.4 medications at last follow-up after surgery (83.8 ± 40.3 months). In eyes that underwent GDI surgery, preoperative IOP was reduced from a mean of 35.2 ± 13.0 mmHg on 2.0 ± 1.3 glaucoma medications to a mean of 8.7 ± 11.2 mmHg on 1.2 ± 1.1 medications at last follow-up after surgery (50.5 ± 40.7 months). Twenty-four eyes (92%) had an IOP less than 22 mmHg, and 22 eyes (85%) had visual acuity 20/400 or better at last follow-up (55.8 ± 41.5 months). Mean number of glaucoma surgeries per patient over the follow-up period was 1.6 ± 1.2. Trabeculectomy with antifibrotic agents had a survival of 73% at 1 year, 44% at 3 years, and 29% at 5 years. Glaucoma drainage implants had a survival of 71% at 1 year, 71% at 3 years, and 53% at 5 years. Conclusions: Glaucoma associated with ICE syndrome can be managed successfully surgically, although multiple procedures are often needed.

Original languageEnglish
Pages (from-to)1789-1795
Number of pages7
JournalOphthalmology
Volume108
Issue number10
DOIs
StatePublished - Oct 9 2001

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Iridocorneal Endothelial Syndrome
Glaucoma
Glaucoma Drainage Implants
Trabeculectomy
Intraocular Pressure
Visual Acuity
Survival
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

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Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. / Doe, Erin A.; Budenz, Donald L.; Gedde, Steven J; Imami, Nauman R.

In: Ophthalmology, Vol. 108, No. 10, 09.10.2001, p. 1789-1795.

Research output: Contribution to journalArticle

Doe, Erin A. ; Budenz, Donald L. ; Gedde, Steven J ; Imami, Nauman R. / Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. In: Ophthalmology. 2001 ; Vol. 108, No. 10. pp. 1789-1795.
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abstract = "Purpose: To report the long-term outcomes of patients with iridocorneal endothelial (ICE) syndrome who required surgery for glaucoma. Design: Retrospective, noncomparative case series. Participants: Twenty-six patients with ICE syndrome who underwent surgery for glaucoma at one institution between January 1987 and January 2000. Main Outcome Measures: Intraocular pressure (IOP), visual acuity, number of glaucoma medications, and further surgical interventions were measured. Results: Five eyes had a trabeculectomy with an antifibrotic agent alone, seven eyes had a trabeculectomy with an antifibrotic agent and a subsequent glaucoma drainage implant (GDI), and 14 eyes had a GDI alone. In eyes that underwent a trabeculectomy with an antifibrotic agent, preoperative IOP was reduced from a mean of 38.8 ± 10.5 mmHg on 2.3 ± 0.8 glaucoma medications to a mean of 11.8 ± 4.3 mmHg on 1.2 ± 1.4 medications at last follow-up after surgery (83.8 ± 40.3 months). In eyes that underwent GDI surgery, preoperative IOP was reduced from a mean of 35.2 ± 13.0 mmHg on 2.0 ± 1.3 glaucoma medications to a mean of 8.7 ± 11.2 mmHg on 1.2 ± 1.1 medications at last follow-up after surgery (50.5 ± 40.7 months). Twenty-four eyes (92{\%}) had an IOP less than 22 mmHg, and 22 eyes (85{\%}) had visual acuity 20/400 or better at last follow-up (55.8 ± 41.5 months). Mean number of glaucoma surgeries per patient over the follow-up period was 1.6 ± 1.2. Trabeculectomy with antifibrotic agents had a survival of 73{\%} at 1 year, 44{\%} at 3 years, and 29{\%} at 5 years. Glaucoma drainage implants had a survival of 71{\%} at 1 year, 71{\%} at 3 years, and 53{\%} at 5 years. Conclusions: Glaucoma associated with ICE syndrome can be managed successfully surgically, although multiple procedures are often needed.",
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