Purpose: To report the long-term outcomes of patients with iridocorneal endothelial (ICE) syndrome who required surgery for glaucoma. Design: Retrospective, noncomparative case series. Participants: Twenty-six patients with ICE syndrome who underwent surgery for glaucoma at one institution between January 1987 and January 2000. Main Outcome Measures: Intraocular pressure (IOP), visual acuity, number of glaucoma medications, and further surgical interventions were measured. Results: Five eyes had a trabeculectomy with an antifibrotic agent alone, seven eyes had a trabeculectomy with an antifibrotic agent and a subsequent glaucoma drainage implant (GDI), and 14 eyes had a GDI alone. In eyes that underwent a trabeculectomy with an antifibrotic agent, preoperative IOP was reduced from a mean of 38.8 ± 10.5 mmHg on 2.3 ± 0.8 glaucoma medications to a mean of 11.8 ± 4.3 mmHg on 1.2 ± 1.4 medications at last follow-up after surgery (83.8 ± 40.3 months). In eyes that underwent GDI surgery, preoperative IOP was reduced from a mean of 35.2 ± 13.0 mmHg on 2.0 ± 1.3 glaucoma medications to a mean of 8.7 ± 11.2 mmHg on 1.2 ± 1.1 medications at last follow-up after surgery (50.5 ± 40.7 months). Twenty-four eyes (92%) had an IOP less than 22 mmHg, and 22 eyes (85%) had visual acuity 20/400 or better at last follow-up (55.8 ± 41.5 months). Mean number of glaucoma surgeries per patient over the follow-up period was 1.6 ± 1.2. Trabeculectomy with antifibrotic agents had a survival of 73% at 1 year, 44% at 3 years, and 29% at 5 years. Glaucoma drainage implants had a survival of 71% at 1 year, 71% at 3 years, and 53% at 5 years. Conclusions: Glaucoma associated with ICE syndrome can be managed successfully surgically, although multiple procedures are often needed.
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