Long-term stability of neural signals from microwire arrays implanted in common marmoset motor cortex and striatum

Shubham Debnath, Noeline W. Prins, Eric Pohlmeyer, Ramanamurthy Mylavarapu, Shijia Geng, Justin C. Sanchez, Abhishek Prasad

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Current neuroprosthetics rely on stable, high quality recordings from chronically implanted microelectrode arrays (MEAs) in neural tissue. While chronic electrophysiological recordings and electrode failure modes have been reported from rodent and larger non-human primate (NHP) models, chronic recordings from the marmoset model have not been previously described. The common marmoset is a New World primate that is easier to breed and handle compared to larger NHPs and has a similarly organized brain, making it a potentially useful smaller NHP model for neuroscience studies. This study reports recording stability and signal quality of MEAs chronically implanted in behaving marmosets. Six adult male marmosets, trained for reaching tasks, were implanted with either a 16-channel tungsten microwire array (five animals) or a Pt-Ir floating MEA (one animal) in the hand-arm region of the primary motor cortex (M1) and another MEA in the striatum targeting the nucleus accumbens (NAcc). Signal stability and quality was quantified as a function of array yield (active electrodes that recorded action potentials), neuronal yield (isolated single units during a recording session), and signal-to-noise ratio (SNR). Out of 11 implanted MEAs, nine provided functional recordings for at least three months, with two arrays functional for 10 months. In general, implants had high yield, which remained stable for up to several months. However, mechanical failure attributed to MEA connector was the most common failure mode. In the longest implants, signal degradation occurred, which was characterized by gradual decline in array yield, reduced number of isolated single units, and changes in waveform shape of action potentials. This work demonstrates the feasibility of long-term recordings from MEAs implanted in cortical and deep brain structures in the marmoset model. The ability to chronically record cortical signals for neural prosthetics applications in the common marmoset extends the potential of this model in neural interface research.

Original languageEnglish (US)
Article number055025
JournalBiomedical Physics and Engineering Express
Volume4
Issue number5
DOIs
StatePublished - Aug 31 2018

Fingerprint

Callithrix
Motor Cortex
Microelectrodes
Primates
Action Potentials
Electrodes
Tungsten
Nucleus Accumbens
Brain
Signal-To-Noise Ratio
Neurosciences
Rodentia
Arm
Hand
Research

Keywords

  • electrode failure
  • marmosets
  • microelectrode array
  • neuroprosthetics

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Long-term stability of neural signals from microwire arrays implanted in common marmoset motor cortex and striatum. / Debnath, Shubham; Prins, Noeline W.; Pohlmeyer, Eric; Mylavarapu, Ramanamurthy; Geng, Shijia; Sanchez, Justin C.; Prasad, Abhishek.

In: Biomedical Physics and Engineering Express, Vol. 4, No. 5, 055025, 31.08.2018.

Research output: Contribution to journalArticle

Debnath, Shubham ; Prins, Noeline W. ; Pohlmeyer, Eric ; Mylavarapu, Ramanamurthy ; Geng, Shijia ; Sanchez, Justin C. ; Prasad, Abhishek. / Long-term stability of neural signals from microwire arrays implanted in common marmoset motor cortex and striatum. In: Biomedical Physics and Engineering Express. 2018 ; Vol. 4, No. 5.
@article{528ca714032047f69fda605634fddd30,
title = "Long-term stability of neural signals from microwire arrays implanted in common marmoset motor cortex and striatum",
abstract = "Current neuroprosthetics rely on stable, high quality recordings from chronically implanted microelectrode arrays (MEAs) in neural tissue. While chronic electrophysiological recordings and electrode failure modes have been reported from rodent and larger non-human primate (NHP) models, chronic recordings from the marmoset model have not been previously described. The common marmoset is a New World primate that is easier to breed and handle compared to larger NHPs and has a similarly organized brain, making it a potentially useful smaller NHP model for neuroscience studies. This study reports recording stability and signal quality of MEAs chronically implanted in behaving marmosets. Six adult male marmosets, trained for reaching tasks, were implanted with either a 16-channel tungsten microwire array (five animals) or a Pt-Ir floating MEA (one animal) in the hand-arm region of the primary motor cortex (M1) and another MEA in the striatum targeting the nucleus accumbens (NAcc). Signal stability and quality was quantified as a function of array yield (active electrodes that recorded action potentials), neuronal yield (isolated single units during a recording session), and signal-to-noise ratio (SNR). Out of 11 implanted MEAs, nine provided functional recordings for at least three months, with two arrays functional for 10 months. In general, implants had high yield, which remained stable for up to several months. However, mechanical failure attributed to MEA connector was the most common failure mode. In the longest implants, signal degradation occurred, which was characterized by gradual decline in array yield, reduced number of isolated single units, and changes in waveform shape of action potentials. This work demonstrates the feasibility of long-term recordings from MEAs implanted in cortical and deep brain structures in the marmoset model. The ability to chronically record cortical signals for neural prosthetics applications in the common marmoset extends the potential of this model in neural interface research.",
keywords = "electrode failure, marmosets, microelectrode array, neuroprosthetics",
author = "Shubham Debnath and Prins, {Noeline W.} and Eric Pohlmeyer and Ramanamurthy Mylavarapu and Shijia Geng and Sanchez, {Justin C.} and Abhishek Prasad",
year = "2018",
month = "8",
day = "31",
doi = "10.1088/2057-1976/aada67",
language = "English (US)",
volume = "4",
journal = "Biomedical Physics and Engineering Express",
issn = "2057-1976",
publisher = "IOP Publishing Ltd.",
number = "5",

}

TY - JOUR

T1 - Long-term stability of neural signals from microwire arrays implanted in common marmoset motor cortex and striatum

AU - Debnath, Shubham

AU - Prins, Noeline W.

AU - Pohlmeyer, Eric

AU - Mylavarapu, Ramanamurthy

AU - Geng, Shijia

AU - Sanchez, Justin C.

AU - Prasad, Abhishek

PY - 2018/8/31

Y1 - 2018/8/31

N2 - Current neuroprosthetics rely on stable, high quality recordings from chronically implanted microelectrode arrays (MEAs) in neural tissue. While chronic electrophysiological recordings and electrode failure modes have been reported from rodent and larger non-human primate (NHP) models, chronic recordings from the marmoset model have not been previously described. The common marmoset is a New World primate that is easier to breed and handle compared to larger NHPs and has a similarly organized brain, making it a potentially useful smaller NHP model for neuroscience studies. This study reports recording stability and signal quality of MEAs chronically implanted in behaving marmosets. Six adult male marmosets, trained for reaching tasks, were implanted with either a 16-channel tungsten microwire array (five animals) or a Pt-Ir floating MEA (one animal) in the hand-arm region of the primary motor cortex (M1) and another MEA in the striatum targeting the nucleus accumbens (NAcc). Signal stability and quality was quantified as a function of array yield (active electrodes that recorded action potentials), neuronal yield (isolated single units during a recording session), and signal-to-noise ratio (SNR). Out of 11 implanted MEAs, nine provided functional recordings for at least three months, with two arrays functional for 10 months. In general, implants had high yield, which remained stable for up to several months. However, mechanical failure attributed to MEA connector was the most common failure mode. In the longest implants, signal degradation occurred, which was characterized by gradual decline in array yield, reduced number of isolated single units, and changes in waveform shape of action potentials. This work demonstrates the feasibility of long-term recordings from MEAs implanted in cortical and deep brain structures in the marmoset model. The ability to chronically record cortical signals for neural prosthetics applications in the common marmoset extends the potential of this model in neural interface research.

AB - Current neuroprosthetics rely on stable, high quality recordings from chronically implanted microelectrode arrays (MEAs) in neural tissue. While chronic electrophysiological recordings and electrode failure modes have been reported from rodent and larger non-human primate (NHP) models, chronic recordings from the marmoset model have not been previously described. The common marmoset is a New World primate that is easier to breed and handle compared to larger NHPs and has a similarly organized brain, making it a potentially useful smaller NHP model for neuroscience studies. This study reports recording stability and signal quality of MEAs chronically implanted in behaving marmosets. Six adult male marmosets, trained for reaching tasks, were implanted with either a 16-channel tungsten microwire array (five animals) or a Pt-Ir floating MEA (one animal) in the hand-arm region of the primary motor cortex (M1) and another MEA in the striatum targeting the nucleus accumbens (NAcc). Signal stability and quality was quantified as a function of array yield (active electrodes that recorded action potentials), neuronal yield (isolated single units during a recording session), and signal-to-noise ratio (SNR). Out of 11 implanted MEAs, nine provided functional recordings for at least three months, with two arrays functional for 10 months. In general, implants had high yield, which remained stable for up to several months. However, mechanical failure attributed to MEA connector was the most common failure mode. In the longest implants, signal degradation occurred, which was characterized by gradual decline in array yield, reduced number of isolated single units, and changes in waveform shape of action potentials. This work demonstrates the feasibility of long-term recordings from MEAs implanted in cortical and deep brain structures in the marmoset model. The ability to chronically record cortical signals for neural prosthetics applications in the common marmoset extends the potential of this model in neural interface research.

KW - electrode failure

KW - marmosets

KW - microelectrode array

KW - neuroprosthetics

UR - http://www.scopus.com/inward/record.url?scp=85053131123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053131123&partnerID=8YFLogxK

U2 - 10.1088/2057-1976/aada67

DO - 10.1088/2057-1976/aada67

M3 - Article

AN - SCOPUS:85053131123

VL - 4

JO - Biomedical Physics and Engineering Express

JF - Biomedical Physics and Engineering Express

SN - 2057-1976

IS - 5

M1 - 055025

ER -