Abstract
Objective: The aim of this study was to determine whether postictal psychotic episodes (PIPE) are predictive of the development of interictal psychotic episodes (IPE). Methods: This was a retrospective study of 18 consecutive adults with a partial seizure disorder and PIPE (study group) and 36 patients with a partial seizure disorder but without PIPE (control group). These two groups were compared with respect to the likelihood of developing IPE over an 8-year follow-up period and the variables operant in the development of IPE. Statistical analyses consisted of logistic regression models to identify the variables predictive of the development of IPE. Predictors included: number and location of ictal foci, seizure type, etiology, age at seizure onset, duration of seizure disorder, MRI abnormalities, and psychiatric history prior to the index video/EEG monitoring (other than PIPE). Results: Seven patients with PIPE and one control patient went on to develop an IPE. Predictors of IPE in univariate logistic regression analyses included a history of PIPE (P = 0.006), male gender (P = 0.028), and having bilateral ictal foci (P = 0.048). Significance disappeared for all of these variables when they were entered into a multivariate analysis. Conclusions: A history of PIPE may be a risk factor for the development of IPE. Yet, the disappearance of significance on multivariate analysis indicates that it is not an independent predictor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 154-156 |
| Number of pages | 3 |
| Journal | Epilepsy and Behavior |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2008 |
| Externally published | Yes |
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Keywords
- Epilepsy surgery
- Intractable epilepsy
- Mesial temporal sclerosis
- Psychosis of epilepsy
- Temporal lobe epilepsy
ASJC Scopus subject areas
- Clinical Neurology
- Behavioral Neuroscience
- Neurology
Cite this
Long-term significance of postictal psychotic episodes. II. Are they predictive of interictal psychotic episodes? / Kanner, Andres M; Ostrovskaya, Anna.
In: Epilepsy and Behavior, Vol. 12, No. 1, 01.2008, p. 154-156.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term significance of postictal psychotic episodes. II. Are they predictive of interictal psychotic episodes?
AU - Kanner, Andres M
AU - Ostrovskaya, Anna
PY - 2008/1
Y1 - 2008/1
N2 - Objective: The aim of this study was to determine whether postictal psychotic episodes (PIPE) are predictive of the development of interictal psychotic episodes (IPE). Methods: This was a retrospective study of 18 consecutive adults with a partial seizure disorder and PIPE (study group) and 36 patients with a partial seizure disorder but without PIPE (control group). These two groups were compared with respect to the likelihood of developing IPE over an 8-year follow-up period and the variables operant in the development of IPE. Statistical analyses consisted of logistic regression models to identify the variables predictive of the development of IPE. Predictors included: number and location of ictal foci, seizure type, etiology, age at seizure onset, duration of seizure disorder, MRI abnormalities, and psychiatric history prior to the index video/EEG monitoring (other than PIPE). Results: Seven patients with PIPE and one control patient went on to develop an IPE. Predictors of IPE in univariate logistic regression analyses included a history of PIPE (P = 0.006), male gender (P = 0.028), and having bilateral ictal foci (P = 0.048). Significance disappeared for all of these variables when they were entered into a multivariate analysis. Conclusions: A history of PIPE may be a risk factor for the development of IPE. Yet, the disappearance of significance on multivariate analysis indicates that it is not an independent predictor.
AB - Objective: The aim of this study was to determine whether postictal psychotic episodes (PIPE) are predictive of the development of interictal psychotic episodes (IPE). Methods: This was a retrospective study of 18 consecutive adults with a partial seizure disorder and PIPE (study group) and 36 patients with a partial seizure disorder but without PIPE (control group). These two groups were compared with respect to the likelihood of developing IPE over an 8-year follow-up period and the variables operant in the development of IPE. Statistical analyses consisted of logistic regression models to identify the variables predictive of the development of IPE. Predictors included: number and location of ictal foci, seizure type, etiology, age at seizure onset, duration of seizure disorder, MRI abnormalities, and psychiatric history prior to the index video/EEG monitoring (other than PIPE). Results: Seven patients with PIPE and one control patient went on to develop an IPE. Predictors of IPE in univariate logistic regression analyses included a history of PIPE (P = 0.006), male gender (P = 0.028), and having bilateral ictal foci (P = 0.048). Significance disappeared for all of these variables when they were entered into a multivariate analysis. Conclusions: A history of PIPE may be a risk factor for the development of IPE. Yet, the disappearance of significance on multivariate analysis indicates that it is not an independent predictor.
KW - Epilepsy surgery
KW - Intractable epilepsy
KW - Mesial temporal sclerosis
KW - Psychosis of epilepsy
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=37049021408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37049021408&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2007.09.007
DO - 10.1016/j.yebeh.2007.09.007
M3 - Article
C2 - 18086459
AN - SCOPUS:37049021408
VL - 12
SP - 154
EP - 156
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
IS - 1
ER -