Long term persistence of IgE anti-varicella zoster virus in pediatric and adult serum post chicken pox infection and after vaccination with varicella virus vaccine

Tamar A. Smith-Norowitz, Joby Josekutty, Jonathan I. Silverberg, Hadar Lev-Tov, Yitzchok M. Norowitz, Stephan Kohlhoff, Maja Nowakowski, Helen G. Durkin, Martin H. Bluth

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The production of IgE specific to different viruses (HIV-1, Parvovirus B19, RSV), and the ability for IgE anti-HIV-1 to suppress HIV-1 production in vitro, strongly suggest an important role for IgE and/or anti viral specific IgE in viral pathogenesis. Previous studies in our laboratory were the first to report the presence of IgE anti-varicella zoster virus (VZV) in an adolescent patient with shingles. However, the presence and long term persistence of IgE anti VZV antibodies has not been studied in adults. The presence of serum IgE in addition to IgE and IgG anti-VZV antibody in sera were studied in children (N=12) (0-16 y/o) and adults (N=9) (32-76 y/o) with either a past history of (wild type) chicken pox (N=7 children, 9 adults) or 5 years after vaccination with varicella zoster (N=2 children) (Varicella virus vaccine live, Oka/Merck), as well as in non-infected subjects (N=3 children). Of the patients who had a positive history of chicken pox 13 of 16 (81%) contained IgE anti-VZV antibodies; they were both serum IgEHi (>100 IU/ml) and IgELo (<100 IU/ml). Of the patients who were vaccinated, IgE anti-VZV antibodies were undetected. In contrast, serum from the patients without a history of chicken pox or vaccination did not make either IgE or IgG anti-VZV antibodies. This is the first demonstration of the existence of IgE anti-VZV antibodies, and its long-term persistence in serum of previously infected subjects. Future studies regarding the functional role of anti-viral IgE and its relationship to VZV are warranted.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalInternational Journal of Biomedical Science
Volume5
Issue number4
StatePublished - Dec 15 2009
Externally publishedYes

Fingerprint

Chickenpox Vaccine
Pediatrics
Human Herpesvirus 3
Chickenpox
Viruses
Vaccination
Vaccines
Infection
Serum
Immunoglobulin E
Antibodies
HIV-1
Herpes Zoster
anti-IgE antibodies
Parvovirus
Demonstrations

Keywords

  • Ige
  • Varicella zoster virus
  • Varicella zoster virus vaccine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Long term persistence of IgE anti-varicella zoster virus in pediatric and adult serum post chicken pox infection and after vaccination with varicella virus vaccine. / Smith-Norowitz, Tamar A.; Josekutty, Joby; Silverberg, Jonathan I.; Lev-Tov, Hadar; Norowitz, Yitzchok M.; Kohlhoff, Stephan; Nowakowski, Maja; Durkin, Helen G.; Bluth, Martin H.

In: International Journal of Biomedical Science, Vol. 5, No. 4, 15.12.2009, p. 353-358.

Research output: Contribution to journalArticle

Smith-Norowitz, TA, Josekutty, J, Silverberg, JI, Lev-Tov, H, Norowitz, YM, Kohlhoff, S, Nowakowski, M, Durkin, HG & Bluth, MH 2009, 'Long term persistence of IgE anti-varicella zoster virus in pediatric and adult serum post chicken pox infection and after vaccination with varicella virus vaccine', International Journal of Biomedical Science, vol. 5, no. 4, pp. 353-358.
Smith-Norowitz, Tamar A. ; Josekutty, Joby ; Silverberg, Jonathan I. ; Lev-Tov, Hadar ; Norowitz, Yitzchok M. ; Kohlhoff, Stephan ; Nowakowski, Maja ; Durkin, Helen G. ; Bluth, Martin H. / Long term persistence of IgE anti-varicella zoster virus in pediatric and adult serum post chicken pox infection and after vaccination with varicella virus vaccine. In: International Journal of Biomedical Science. 2009 ; Vol. 5, No. 4. pp. 353-358.
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abstract = "The production of IgE specific to different viruses (HIV-1, Parvovirus B19, RSV), and the ability for IgE anti-HIV-1 to suppress HIV-1 production in vitro, strongly suggest an important role for IgE and/or anti viral specific IgE in viral pathogenesis. Previous studies in our laboratory were the first to report the presence of IgE anti-varicella zoster virus (VZV) in an adolescent patient with shingles. However, the presence and long term persistence of IgE anti VZV antibodies has not been studied in adults. The presence of serum IgE in addition to IgE and IgG anti-VZV antibody in sera were studied in children (N=12) (0-16 y/o) and adults (N=9) (32-76 y/o) with either a past history of (wild type) chicken pox (N=7 children, 9 adults) or 5 years after vaccination with varicella zoster (N=2 children) (Varicella virus vaccine live, Oka/Merck), as well as in non-infected subjects (N=3 children). Of the patients who had a positive history of chicken pox 13 of 16 (81{\%}) contained IgE anti-VZV antibodies; they were both serum IgEHi (>100 IU/ml) and IgELo (<100 IU/ml). Of the patients who were vaccinated, IgE anti-VZV antibodies were undetected. In contrast, serum from the patients without a history of chicken pox or vaccination did not make either IgE or IgG anti-VZV antibodies. This is the first demonstration of the existence of IgE anti-VZV antibodies, and its long-term persistence in serum of previously infected subjects. Future studies regarding the functional role of anti-viral IgE and its relationship to VZV are warranted.",
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AU - Lev-Tov, Hadar

AU - Norowitz, Yitzchok M.

AU - Kohlhoff, Stephan

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AU - Durkin, Helen G.

AU - Bluth, Martin H.

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