Long-term PERG monitoring of untreated and treated glaucoma suspects

Phillip S. Gordon, Maja Kostic, Pedro F. Monsalve, Giacinto Triolo, Luri Golubev, Gabriel Luna, Lori M. Ventura, William J. Feuer, Vittorio Porciatti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate long-term structural and functional progression of untreated and treated glaucoma suspects (UGS and TGS). Methods: Retrospective analysis of serial steady-state pattern electroretinogram (PERG), mean retinal nerve fiber layer thickness (RNFLT), and standard automated perimetry mean deviation (SAP-MD) in UGS (N = 20) and TGS (N = 18). Outcome measures were the rates of change (linear regression slopes) of PERG amplitude, PERG phase, mean RNFLT, and SAP-MD over 9.8 ± 1.3 years (15.6 ± 4.2 visits). Results: The number of patients with significant (P < 0.05) progression slopes for PERG amplitude, PERG phase, RNFLT, and SAP-MD was, respectively, UGS: 5, 0, 4, 2; TGS: 8, 2, 6, 5. In UGS, outcome measures were not correlated with each other. In TGS, both PERG amplitude and RNFLT were significantly (P < 0.05) correlated with SAP-MD (R ≥ 0.58), while PERG amplitude and RNFLT were not correlated with each other (R = 0.43, P = 0.064). The rate of change of SAP-MD was predicted (P < 0.05) by a linear combination of RNFLT slope and PERG amplitude slope. Conclusions: Results substantiate and extend previous results showing that steady-state PERG amplitude progressively decreased over time in a proportion of glaucoma suspects, with relatively steeper slope in TGS compared to UGS. RNFLT progression also had a steeper slope in TGS compared to UGS; however, progressions of PERG amplitude and RNFLT were not significantly correlated. Both PERG progression and RNFLT progression independently contribute to prediction of visual field progression.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalDocumenta Ophthalmologica
Volume141
Issue number2
DOIs
StatePublished - Oct 1 2020

Keywords

  • Glaucoma suspects
  • Pattern electroretinogram
  • Retinal ganglion cell function
  • Retinal nerve fiber layer thickness

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Physiology (medical)

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