Resultados a longo prazo do uso de drogas antiproliferativas na trabeculectomia primária

Translated title of the contribution: Long-term outcomes of antiproliferative agents in primary trabeculectomy

Eleonore J. Norris, Joyce C. Schiffman, Paul F. Palmberg, Paulo Augusto De Arruda Mello

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: To evaluate and compare long-term outcomes of trabeculectomies with subconjunctival injections of 5-fluorouracil (5-FU) after sugery or use of mitomycin C (MMC) during surgery. Methods: Retrospective study of 133 eyes who underwent primary trabeculectomy. Results: Intraocular pressure levels were not statistically significant at any of the postoperative visits when comparing the 5-fluorouracil and mitomycin C groups. In each group, analyzed separately, the intra-ocular pressure levels showed no statistically significant difference before or after surgery. The incidence of postoperative complications was not statistically significant as well, except for a greater incidence of the corneal epithelial defects, more frequent in the 5-fluorouracil group. In both groups, a greater incidence of development/progression of cataract was noted. Conclusion: Both mitomycin C and 5-fluorouracil promoted an important and stable decrease in intraocular pressure with similar complication rates.

Translated title of the contributionLong-term outcomes of antiproliferative agents in primary trabeculectomy
Original languagePortuguese
Pages (from-to)409-413
Number of pages5
JournalArquivos Brasileiros de Oftalmologia
Issue number4
StatePublished - 2002
Externally publishedYes


  • Fluorouracil/administration & dosage
  • Fluorouracil/therapeutic use
  • Glaucoma/surgery
  • Intraocular pressure/drug effects
  • Mitomycins/administration & dosage
  • Mitomycins/therapeutic use
  • Retrospective studies
  • Trabeculectomy
  • Visual fields

ASJC Scopus subject areas

  • Ophthalmology


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