Resultados a longo prazo do uso de drogas antiproliferativas na trabeculectomia primária

Eleonore J. Norris; Joyce C. Schiffman; Paul F. Palmberg; Paulo Augusto De Arruda Mello

doi:10.1590/s0004-27492002000400003

Resultados a longo prazo do uso de drogas antiproliferativas na trabeculectomia primária

Translated title of the contribution: Long-term outcomes of antiproliferative agents in primary trabeculectomy

Eleonore J. Norris, Joyce C. Schiffman, Paul F. Palmberg, Paulo Augusto De Arruda Mello

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Purpose: To evaluate and compare long-term outcomes of trabeculectomies with subconjunctival injections of 5-fluorouracil (5-FU) after sugery or use of mitomycin C (MMC) during surgery. Methods: Retrospective study of 133 eyes who underwent primary trabeculectomy. Results: Intraocular pressure levels were not statistically significant at any of the postoperative visits when comparing the 5-fluorouracil and mitomycin C groups. In each group, analyzed separately, the intra-ocular pressure levels showed no statistically significant difference before or after surgery. The incidence of postoperative complications was not statistically significant as well, except for a greater incidence of the corneal epithelial defects, more frequent in the 5-fluorouracil group. In both groups, a greater incidence of development/progression of cataract was noted. Conclusion: Both mitomycin C and 5-fluorouracil promoted an important and stable decrease in intraocular pressure with similar complication rates.

Translated title of the contribution	Long-term outcomes of antiproliferative agents in primary trabeculectomy
Original language	Portuguese
Pages (from-to)	409-413
Number of pages	5
Journal	Arquivos Brasileiros de Oftalmologia
Volume	65
Issue number	4
DOIs	https://doi.org/10.1590/s0004-27492002000400003
State	Published - 2002
Externally published	Yes

Keywords

Fluorouracil/administration & dosage
Fluorouracil/therapeutic use
Glaucoma/surgery
Intraocular pressure/drug effects
Mitomycins/administration & dosage
Mitomycins/therapeutic use
Retrospective studies
Trabeculectomy
Visual fields

ASJC Scopus subject areas

Ophthalmology

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Norris, E. J., Schiffman, J. C., Palmberg, P. F., & Mello, P. A. D. A. (2002). Resultados a longo prazo do uso de drogas antiproliferativas na trabeculectomia primária. Arquivos Brasileiros de Oftalmologia, 65(4), 409-413. https://doi.org/10.1590/s0004-27492002000400003

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abstract = "Purpose: To evaluate and compare long-term outcomes of trabeculectomies with subconjunctival injections of 5-fluorouracil (5-FU) after sugery or use of mitomycin C (MMC) during surgery. Methods: Retrospective study of 133 eyes who underwent primary trabeculectomy. Results: Intraocular pressure levels were not statistically significant at any of the postoperative visits when comparing the 5-fluorouracil and mitomycin C groups. In each group, analyzed separately, the intra-ocular pressure levels showed no statistically significant difference before or after surgery. The incidence of postoperative complications was not statistically significant as well, except for a greater incidence of the corneal epithelial defects, more frequent in the 5-fluorouracil group. In both groups, a greater incidence of development/progression of cataract was noted. Conclusion: Both mitomycin C and 5-fluorouracil promoted an important and stable decrease in intraocular pressure with similar complication rates.",

keywords = "Fluorouracil/administration & dosage, Fluorouracil/therapeutic use, Glaucoma/surgery, Intraocular pressure/drug effects, Mitomycins/administration & dosage, Mitomycins/therapeutic use, Retrospective studies, Trabeculectomy, Visual fields",

author = "Norris, {Eleonore J.} and Schiffman, {Joyce C.} and Palmberg, {Paul F.} and Mello, {Paulo Augusto De Arruda}",

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AU - Palmberg, Paul F.

AU - Mello, Paulo Augusto De Arruda

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N2 - Purpose: To evaluate and compare long-term outcomes of trabeculectomies with subconjunctival injections of 5-fluorouracil (5-FU) after sugery or use of mitomycin C (MMC) during surgery. Methods: Retrospective study of 133 eyes who underwent primary trabeculectomy. Results: Intraocular pressure levels were not statistically significant at any of the postoperative visits when comparing the 5-fluorouracil and mitomycin C groups. In each group, analyzed separately, the intra-ocular pressure levels showed no statistically significant difference before or after surgery. The incidence of postoperative complications was not statistically significant as well, except for a greater incidence of the corneal epithelial defects, more frequent in the 5-fluorouracil group. In both groups, a greater incidence of development/progression of cataract was noted. Conclusion: Both mitomycin C and 5-fluorouracil promoted an important and stable decrease in intraocular pressure with similar complication rates.

AB - Purpose: To evaluate and compare long-term outcomes of trabeculectomies with subconjunctival injections of 5-fluorouracil (5-FU) after sugery or use of mitomycin C (MMC) during surgery. Methods: Retrospective study of 133 eyes who underwent primary trabeculectomy. Results: Intraocular pressure levels were not statistically significant at any of the postoperative visits when comparing the 5-fluorouracil and mitomycin C groups. In each group, analyzed separately, the intra-ocular pressure levels showed no statistically significant difference before or after surgery. The incidence of postoperative complications was not statistically significant as well, except for a greater incidence of the corneal epithelial defects, more frequent in the 5-fluorouracil group. In both groups, a greater incidence of development/progression of cataract was noted. Conclusion: Both mitomycin C and 5-fluorouracil promoted an important and stable decrease in intraocular pressure with similar complication rates.

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KW - Fluorouracil/therapeutic use

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KW - Mitomycins/therapeutic use

KW - Retrospective studies

KW - Trabeculectomy

KW - Visual fields

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