Abstract
Purpose: To evaluate and compare long-term outcomes of trabeculectomies with subconjunctival injections of 5-fluorouracil (5-FU) after sugery or use of mitomycin C (MMC) during surgery. Methods: Retrospective study of 133 eyes who underwent primary trabeculectomy. Results: Intraocular pressure levels were not statistically significant at any of the postoperative visits when comparing the 5-fluorouracil and mitomycin C groups. In each group, analyzed separately, the intra-ocular pressure levels showed no statistically significant difference before or after surgery. The incidence of postoperative complications was not statistically significant as well, except for a greater incidence of the corneal epithelial defects, more frequent in the 5-fluorouracil group. In both groups, a greater incidence of development/progression of cataract was noted. Conclusion: Both mitomycin C and 5-fluorouracil promoted an important and stable decrease in intraocular pressure with similar complication rates.
| Translated title of the contribution | Long-term outcomes of antiproliferative agents in primary trabeculectomy |
|---|---|
| Original language | Portuguese |
| Pages (from-to) | 409-413 |
| Number of pages | 5 |
| Journal | Arquivos Brasileiros de Oftalmologia |
| Volume | 65 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
Keywords
- Fluorouracil/administration & dosage
- Fluorouracil/therapeutic use
- Glaucoma/surgery
- Intraocular pressure/drug effects
- Mitomycins/administration & dosage
- Mitomycins/therapeutic use
- Retrospective studies
- Trabeculectomy
- Visual fields
ASJC Scopus subject areas
- Ophthalmology