Abstract
Introduction: Some groups have reported the longitudinal course of elderly poor outcome schizophrenic patients to be characterized by progressive decline in cognitive functions and functional capacity. Although many of these patients experience minimal reduction of psychotic symptoms, there may be beneficial effects of antipsychotic treatments on cognitive functions and functional capacity. Methods: This naturalistic study compared the longitudinal course of psychotic symptoms, cognitive functions and functional impairment in geriatric schizophrenic patients treated with first generation (N = 97) or second generation (N = 78) antipsychotic medications. Mixed effects linear regression analyses were used to examine the effects of treatment (first generation vs. second generation antipsychotic), time and treatment × time. Results: Cognitive functions (Mini Mental State Examination time effect estimate = - .41, p < .001; ADAS-L Cog time effect estimate = .64, p < .001) and self-care skills (ADAS-L Self-Care time effect estimate = .65, p < .001) declined over time for the subject group as a whole and this decline was not modified by treatment with second generation antipsychotics relative to first generation antipsychotics. Similarly, second generation antipsychotic treatment produced no effect on the progressive worsening of negative symptom over time. Conclusion: This long-term naturalistic study of poor outcome geriatric patients with schizophrenia did not find atypical antipsychotics to produce any differential protective effect relative to typical antipsychotics on the long-term manifestations of symptoms, cognition and self-care in poor outcome geriatric schizophrenic patients.
| Original language | English |
|---|---|
| Pages (from-to) | 127-134 |
| Number of pages | 8 |
| Journal | Schizophrenia Research |
| Volume | 88 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Dec 1 2006 |
| Externally published | Yes |
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Keywords
- Antipsychotic
- Cognition
- Geriatric
- Schizophrenia
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
Long-term outcomes in chronically hospitalized geriatric patients with schizophrenia : Retrospective comparison of first generation and second generation antipsychotics. / White, Leonard; Friedman, Joseph I.; Bowie, Christopher R.; Evers, Martin; Harvey, Philip D; Parrella, Michael; Mihaila, Emilian; Davis, Kenneth L.
In: Schizophrenia Research, Vol. 88, No. 1-3, 01.12.2006, p. 127-134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term outcomes in chronically hospitalized geriatric patients with schizophrenia
T2 - Retrospective comparison of first generation and second generation antipsychotics
AU - White, Leonard
AU - Friedman, Joseph I.
AU - Bowie, Christopher R.
AU - Evers, Martin
AU - Harvey, Philip D
AU - Parrella, Michael
AU - Mihaila, Emilian
AU - Davis, Kenneth L.
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Introduction: Some groups have reported the longitudinal course of elderly poor outcome schizophrenic patients to be characterized by progressive decline in cognitive functions and functional capacity. Although many of these patients experience minimal reduction of psychotic symptoms, there may be beneficial effects of antipsychotic treatments on cognitive functions and functional capacity. Methods: This naturalistic study compared the longitudinal course of psychotic symptoms, cognitive functions and functional impairment in geriatric schizophrenic patients treated with first generation (N = 97) or second generation (N = 78) antipsychotic medications. Mixed effects linear regression analyses were used to examine the effects of treatment (first generation vs. second generation antipsychotic), time and treatment × time. Results: Cognitive functions (Mini Mental State Examination time effect estimate = - .41, p < .001; ADAS-L Cog time effect estimate = .64, p < .001) and self-care skills (ADAS-L Self-Care time effect estimate = .65, p < .001) declined over time for the subject group as a whole and this decline was not modified by treatment with second generation antipsychotics relative to first generation antipsychotics. Similarly, second generation antipsychotic treatment produced no effect on the progressive worsening of negative symptom over time. Conclusion: This long-term naturalistic study of poor outcome geriatric patients with schizophrenia did not find atypical antipsychotics to produce any differential protective effect relative to typical antipsychotics on the long-term manifestations of symptoms, cognition and self-care in poor outcome geriatric schizophrenic patients.
AB - Introduction: Some groups have reported the longitudinal course of elderly poor outcome schizophrenic patients to be characterized by progressive decline in cognitive functions and functional capacity. Although many of these patients experience minimal reduction of psychotic symptoms, there may be beneficial effects of antipsychotic treatments on cognitive functions and functional capacity. Methods: This naturalistic study compared the longitudinal course of psychotic symptoms, cognitive functions and functional impairment in geriatric schizophrenic patients treated with first generation (N = 97) or second generation (N = 78) antipsychotic medications. Mixed effects linear regression analyses were used to examine the effects of treatment (first generation vs. second generation antipsychotic), time and treatment × time. Results: Cognitive functions (Mini Mental State Examination time effect estimate = - .41, p < .001; ADAS-L Cog time effect estimate = .64, p < .001) and self-care skills (ADAS-L Self-Care time effect estimate = .65, p < .001) declined over time for the subject group as a whole and this decline was not modified by treatment with second generation antipsychotics relative to first generation antipsychotics. Similarly, second generation antipsychotic treatment produced no effect on the progressive worsening of negative symptom over time. Conclusion: This long-term naturalistic study of poor outcome geriatric patients with schizophrenia did not find atypical antipsychotics to produce any differential protective effect relative to typical antipsychotics on the long-term manifestations of symptoms, cognition and self-care in poor outcome geriatric schizophrenic patients.
KW - Antipsychotic
KW - Cognition
KW - Geriatric
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=33750605155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750605155&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2006.06.038
DO - 10.1016/j.schres.2006.06.038
M3 - Article
C2 - 16926093
AN - SCOPUS:33750605155
VL - 88
SP - 127
EP - 134
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -