Long-term mortality in frail elderly subjects with osteoarthritis

Francesco Cacciatore, David Della Morte, Claudia Basile, Francesca Mazzella, Chiara Mastrobuoni, Elisa Salsano, Gaetano Gargiulo, Gianluigi Galizia, Franco Rengo, Domenico Bonaduce, Pasquale Abete

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective. Elderly subjects are characterized by a high prevalence of OA and clinical frailty. This study aimed to examine the predictive role of clinical frailty on long-term mortality in elderly subjects with and without OA.Methods. Mortality was evaluated after a 12-year follow-up in 698 subjects with and 590 subjects without OA recruited in 1992. Clinical frailty was assessed according to the Frailty Staging System and stratified in tertiles.Results. After a 12-year follow-up, mortality was 42.2% in subjects without and 55.8% in subjects with OA (P = 0.256). With increasing frailty, mortality increased by 30.5% (P for trend < 0.001) in subjects without and by 45.6% in subjects with OA (P for trend < 0.001). Multivariate analysis showed that frailty [hazard ratio (HR) = 1.49 for each unit of increase, 95% CI 1.32, 1.94, P < 0.001) but not OA (HR = 1.28, 95% CI 0.987, 1.39, P = 0.412) was predictive of long-term mortality. Moreover, when Cox regression analysis was performed, frailty enhanced the risk of long-term mortality for each unit of increase by 32% (HR = 1.32, 95% CI 1.06, 1.65, P = 0.03) in the absence of OA and by 98% in the presence (HR = 1.98, 95% CI 1.63, 2.95, P < 0.01) of OA.Conclusion. Clinical frailty significantly predicts mortality in subjects without OA and even more in those with OA. Thus clinical frailty may be considered a new prognostic factor to identify subjects with OA at high risk of mortality.

Original languageEnglish
Article numberket348
Pages (from-to)293-299
Number of pages7
JournalRheumatology (United Kingdom)
Volume53
Issue number2
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Fingerprint

Frail Elderly
Osteoarthritis
Mortality
Multivariate Analysis
Regression Analysis

Keywords

  • Elderly
  • Frailty
  • Mortality
  • Osteoarthritis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

Cacciatore, F., Della Morte, D., Basile, C., Mazzella, F., Mastrobuoni, C., Salsano, E., ... Abete, P. (2014). Long-term mortality in frail elderly subjects with osteoarthritis. Rheumatology (United Kingdom), 53(2), 293-299. [ket348]. https://doi.org/10.1093/rheumatology/ket348

Long-term mortality in frail elderly subjects with osteoarthritis. / Cacciatore, Francesco; Della Morte, David; Basile, Claudia; Mazzella, Francesca; Mastrobuoni, Chiara; Salsano, Elisa; Gargiulo, Gaetano; Galizia, Gianluigi; Rengo, Franco; Bonaduce, Domenico; Abete, Pasquale.

In: Rheumatology (United Kingdom), Vol. 53, No. 2, ket348, 01.02.2014, p. 293-299.

Research output: Contribution to journalArticle

Cacciatore, F, Della Morte, D, Basile, C, Mazzella, F, Mastrobuoni, C, Salsano, E, Gargiulo, G, Galizia, G, Rengo, F, Bonaduce, D & Abete, P 2014, 'Long-term mortality in frail elderly subjects with osteoarthritis', Rheumatology (United Kingdom), vol. 53, no. 2, ket348, pp. 293-299. https://doi.org/10.1093/rheumatology/ket348
Cacciatore F, Della Morte D, Basile C, Mazzella F, Mastrobuoni C, Salsano E et al. Long-term mortality in frail elderly subjects with osteoarthritis. Rheumatology (United Kingdom). 2014 Feb 1;53(2):293-299. ket348. https://doi.org/10.1093/rheumatology/ket348
Cacciatore, Francesco ; Della Morte, David ; Basile, Claudia ; Mazzella, Francesca ; Mastrobuoni, Chiara ; Salsano, Elisa ; Gargiulo, Gaetano ; Galizia, Gianluigi ; Rengo, Franco ; Bonaduce, Domenico ; Abete, Pasquale. / Long-term mortality in frail elderly subjects with osteoarthritis. In: Rheumatology (United Kingdom). 2014 ; Vol. 53, No. 2. pp. 293-299.
@article{fedbe6f7a6ea4a2f949f9ed7cc71e366,
title = "Long-term mortality in frail elderly subjects with osteoarthritis",
abstract = "Objective. Elderly subjects are characterized by a high prevalence of OA and clinical frailty. This study aimed to examine the predictive role of clinical frailty on long-term mortality in elderly subjects with and without OA.Methods. Mortality was evaluated after a 12-year follow-up in 698 subjects with and 590 subjects without OA recruited in 1992. Clinical frailty was assessed according to the Frailty Staging System and stratified in tertiles.Results. After a 12-year follow-up, mortality was 42.2{\%} in subjects without and 55.8{\%} in subjects with OA (P = 0.256). With increasing frailty, mortality increased by 30.5{\%} (P for trend < 0.001) in subjects without and by 45.6{\%} in subjects with OA (P for trend < 0.001). Multivariate analysis showed that frailty [hazard ratio (HR) = 1.49 for each unit of increase, 95{\%} CI 1.32, 1.94, P < 0.001) but not OA (HR = 1.28, 95{\%} CI 0.987, 1.39, P = 0.412) was predictive of long-term mortality. Moreover, when Cox regression analysis was performed, frailty enhanced the risk of long-term mortality for each unit of increase by 32{\%} (HR = 1.32, 95{\%} CI 1.06, 1.65, P = 0.03) in the absence of OA and by 98{\%} in the presence (HR = 1.98, 95{\%} CI 1.63, 2.95, P < 0.01) of OA.Conclusion. Clinical frailty significantly predicts mortality in subjects without OA and even more in those with OA. Thus clinical frailty may be considered a new prognostic factor to identify subjects with OA at high risk of mortality.",
keywords = "Elderly, Frailty, Mortality, Osteoarthritis",
author = "Francesco Cacciatore and {Della Morte}, David and Claudia Basile and Francesca Mazzella and Chiara Mastrobuoni and Elisa Salsano and Gaetano Gargiulo and Gianluigi Galizia and Franco Rengo and Domenico Bonaduce and Pasquale Abete",
year = "2014",
month = "2",
day = "1",
doi = "10.1093/rheumatology/ket348",
language = "English",
volume = "53",
pages = "293--299",
journal = "Rheumatology (United Kingdom)",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Long-term mortality in frail elderly subjects with osteoarthritis

AU - Cacciatore, Francesco

AU - Della Morte, David

AU - Basile, Claudia

AU - Mazzella, Francesca

AU - Mastrobuoni, Chiara

AU - Salsano, Elisa

AU - Gargiulo, Gaetano

AU - Galizia, Gianluigi

AU - Rengo, Franco

AU - Bonaduce, Domenico

AU - Abete, Pasquale

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Objective. Elderly subjects are characterized by a high prevalence of OA and clinical frailty. This study aimed to examine the predictive role of clinical frailty on long-term mortality in elderly subjects with and without OA.Methods. Mortality was evaluated after a 12-year follow-up in 698 subjects with and 590 subjects without OA recruited in 1992. Clinical frailty was assessed according to the Frailty Staging System and stratified in tertiles.Results. After a 12-year follow-up, mortality was 42.2% in subjects without and 55.8% in subjects with OA (P = 0.256). With increasing frailty, mortality increased by 30.5% (P for trend < 0.001) in subjects without and by 45.6% in subjects with OA (P for trend < 0.001). Multivariate analysis showed that frailty [hazard ratio (HR) = 1.49 for each unit of increase, 95% CI 1.32, 1.94, P < 0.001) but not OA (HR = 1.28, 95% CI 0.987, 1.39, P = 0.412) was predictive of long-term mortality. Moreover, when Cox regression analysis was performed, frailty enhanced the risk of long-term mortality for each unit of increase by 32% (HR = 1.32, 95% CI 1.06, 1.65, P = 0.03) in the absence of OA and by 98% in the presence (HR = 1.98, 95% CI 1.63, 2.95, P < 0.01) of OA.Conclusion. Clinical frailty significantly predicts mortality in subjects without OA and even more in those with OA. Thus clinical frailty may be considered a new prognostic factor to identify subjects with OA at high risk of mortality.

AB - Objective. Elderly subjects are characterized by a high prevalence of OA and clinical frailty. This study aimed to examine the predictive role of clinical frailty on long-term mortality in elderly subjects with and without OA.Methods. Mortality was evaluated after a 12-year follow-up in 698 subjects with and 590 subjects without OA recruited in 1992. Clinical frailty was assessed according to the Frailty Staging System and stratified in tertiles.Results. After a 12-year follow-up, mortality was 42.2% in subjects without and 55.8% in subjects with OA (P = 0.256). With increasing frailty, mortality increased by 30.5% (P for trend < 0.001) in subjects without and by 45.6% in subjects with OA (P for trend < 0.001). Multivariate analysis showed that frailty [hazard ratio (HR) = 1.49 for each unit of increase, 95% CI 1.32, 1.94, P < 0.001) but not OA (HR = 1.28, 95% CI 0.987, 1.39, P = 0.412) was predictive of long-term mortality. Moreover, when Cox regression analysis was performed, frailty enhanced the risk of long-term mortality for each unit of increase by 32% (HR = 1.32, 95% CI 1.06, 1.65, P = 0.03) in the absence of OA and by 98% in the presence (HR = 1.98, 95% CI 1.63, 2.95, P < 0.01) of OA.Conclusion. Clinical frailty significantly predicts mortality in subjects without OA and even more in those with OA. Thus clinical frailty may be considered a new prognostic factor to identify subjects with OA at high risk of mortality.

KW - Elderly

KW - Frailty

KW - Mortality

KW - Osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=84892536770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892536770&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/ket348

DO - 10.1093/rheumatology/ket348

M3 - Article

C2 - 24158755

AN - SCOPUS:84892536770

VL - 53

SP - 293

EP - 299

JO - Rheumatology (United Kingdom)

JF - Rheumatology (United Kingdom)

SN - 1462-0324

IS - 2

M1 - ket348

ER -