Abstract
Objective. Elderly subjects are characterized by a high prevalence of OA and clinical frailty. This study aimed to examine the predictive role of clinical frailty on long-term mortality in elderly subjects with and without OA.Methods. Mortality was evaluated after a 12-year follow-up in 698 subjects with and 590 subjects without OA recruited in 1992. Clinical frailty was assessed according to the Frailty Staging System and stratified in tertiles.Results. After a 12-year follow-up, mortality was 42.2% in subjects without and 55.8% in subjects with OA (P = 0.256). With increasing frailty, mortality increased by 30.5% (P for trend < 0.001) in subjects without and by 45.6% in subjects with OA (P for trend < 0.001). Multivariate analysis showed that frailty [hazard ratio (HR) = 1.49 for each unit of increase, 95% CI 1.32, 1.94, P < 0.001) but not OA (HR = 1.28, 95% CI 0.987, 1.39, P = 0.412) was predictive of long-term mortality. Moreover, when Cox regression analysis was performed, frailty enhanced the risk of long-term mortality for each unit of increase by 32% (HR = 1.32, 95% CI 1.06, 1.65, P = 0.03) in the absence of OA and by 98% in the presence (HR = 1.98, 95% CI 1.63, 2.95, P < 0.01) of OA.Conclusion. Clinical frailty significantly predicts mortality in subjects without OA and even more in those with OA. Thus clinical frailty may be considered a new prognostic factor to identify subjects with OA at high risk of mortality.
| Original language | English |
|---|---|
| Article number | ket348 |
| Pages (from-to) | 293-299 |
| Number of pages | 7 |
| Journal | Rheumatology (United Kingdom) |
| Volume | 53 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2014 |
| Externally published | Yes |
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Keywords
- Elderly
- Frailty
- Mortality
- Osteoarthritis
ASJC Scopus subject areas
- Rheumatology
- Pharmacology (medical)
Cite this
Long-term mortality in frail elderly subjects with osteoarthritis. / Cacciatore, Francesco; Della Morte, David; Basile, Claudia; Mazzella, Francesca; Mastrobuoni, Chiara; Salsano, Elisa; Gargiulo, Gaetano; Galizia, Gianluigi; Rengo, Franco; Bonaduce, Domenico; Abete, Pasquale.
In: Rheumatology (United Kingdom), Vol. 53, No. 2, ket348, 01.02.2014, p. 293-299.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term mortality in frail elderly subjects with osteoarthritis
AU - Cacciatore, Francesco
AU - Della Morte, David
AU - Basile, Claudia
AU - Mazzella, Francesca
AU - Mastrobuoni, Chiara
AU - Salsano, Elisa
AU - Gargiulo, Gaetano
AU - Galizia, Gianluigi
AU - Rengo, Franco
AU - Bonaduce, Domenico
AU - Abete, Pasquale
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Objective. Elderly subjects are characterized by a high prevalence of OA and clinical frailty. This study aimed to examine the predictive role of clinical frailty on long-term mortality in elderly subjects with and without OA.Methods. Mortality was evaluated after a 12-year follow-up in 698 subjects with and 590 subjects without OA recruited in 1992. Clinical frailty was assessed according to the Frailty Staging System and stratified in tertiles.Results. After a 12-year follow-up, mortality was 42.2% in subjects without and 55.8% in subjects with OA (P = 0.256). With increasing frailty, mortality increased by 30.5% (P for trend < 0.001) in subjects without and by 45.6% in subjects with OA (P for trend < 0.001). Multivariate analysis showed that frailty [hazard ratio (HR) = 1.49 for each unit of increase, 95% CI 1.32, 1.94, P < 0.001) but not OA (HR = 1.28, 95% CI 0.987, 1.39, P = 0.412) was predictive of long-term mortality. Moreover, when Cox regression analysis was performed, frailty enhanced the risk of long-term mortality for each unit of increase by 32% (HR = 1.32, 95% CI 1.06, 1.65, P = 0.03) in the absence of OA and by 98% in the presence (HR = 1.98, 95% CI 1.63, 2.95, P < 0.01) of OA.Conclusion. Clinical frailty significantly predicts mortality in subjects without OA and even more in those with OA. Thus clinical frailty may be considered a new prognostic factor to identify subjects with OA at high risk of mortality.
AB - Objective. Elderly subjects are characterized by a high prevalence of OA and clinical frailty. This study aimed to examine the predictive role of clinical frailty on long-term mortality in elderly subjects with and without OA.Methods. Mortality was evaluated after a 12-year follow-up in 698 subjects with and 590 subjects without OA recruited in 1992. Clinical frailty was assessed according to the Frailty Staging System and stratified in tertiles.Results. After a 12-year follow-up, mortality was 42.2% in subjects without and 55.8% in subjects with OA (P = 0.256). With increasing frailty, mortality increased by 30.5% (P for trend < 0.001) in subjects without and by 45.6% in subjects with OA (P for trend < 0.001). Multivariate analysis showed that frailty [hazard ratio (HR) = 1.49 for each unit of increase, 95% CI 1.32, 1.94, P < 0.001) but not OA (HR = 1.28, 95% CI 0.987, 1.39, P = 0.412) was predictive of long-term mortality. Moreover, when Cox regression analysis was performed, frailty enhanced the risk of long-term mortality for each unit of increase by 32% (HR = 1.32, 95% CI 1.06, 1.65, P = 0.03) in the absence of OA and by 98% in the presence (HR = 1.98, 95% CI 1.63, 2.95, P < 0.01) of OA.Conclusion. Clinical frailty significantly predicts mortality in subjects without OA and even more in those with OA. Thus clinical frailty may be considered a new prognostic factor to identify subjects with OA at high risk of mortality.
KW - Elderly
KW - Frailty
KW - Mortality
KW - Osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=84892536770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892536770&partnerID=8YFLogxK
U2 - 10.1093/rheumatology/ket348
DO - 10.1093/rheumatology/ket348
M3 - Article
C2 - 24158755
AN - SCOPUS:84892536770
VL - 53
SP - 293
EP - 299
JO - Rheumatology (United Kingdom)
JF - Rheumatology (United Kingdom)
SN - 1462-0324
IS - 2
M1 - ket348
ER -