Abstract
Long-term memory of cocaine-associated context was established by conditioned place preference learning. After 1 week, exposure to context in the absence of cocaine (memory retrieval) was paired with one of the following treatments: saline, scopolamine (muscarinic acetylcholine receptor antagonist), dizocilpine (MK-801; noncompetitive N-methyl-D-aspartate antagonist) or D-cycloserine (partial N-methyl-D-aspartate agonist). In subsequent conditioned place preference tests, place preference was suppressed in the drug-treated groups but not saline-treated groups. Results suggest that the amnesic agents, scopolamine and MK-801, disrupted reconsolidation of cocaine-associated contextual memory. In contrast, the mnemonic agent D-cycloserine might have facilitated extinction learning during context exposure in the absence of cocaine. Challenge administration of cocaine reinstated place preference in all groups except the MK-801 group, suggesting that suppression of conditioned response may or may not suppress memory evoked by drug-context reexposure.
Original language | English (US) |
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Pages (from-to) | 777-780 |
Number of pages | 4 |
Journal | Neuroreport |
Volume | 18 |
Issue number | 8 |
DOIs | |
State | Published - May 2007 |
Keywords
- Cocaine
- Conditioned place preference
- Extinction
- Reconsolidation
- Reinstatement
ASJC Scopus subject areas
- Neuroscience(all)