Long-term memory of cocaine-associated context: Disruption and reinstatement

Jonathan B. Kelley, Karen L. Anderson, Yossef Itzhak

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Long-term memory of cocaine-associated context was established by conditioned place preference learning. After 1 week, exposure to context in the absence of cocaine (memory retrieval) was paired with one of the following treatments: saline, scopolamine (muscarinic acetylcholine receptor antagonist), dizocilpine (MK-801; noncompetitive N-methyl-D-aspartate antagonist) or D-cycloserine (partial N-methyl-D-aspartate agonist). In subsequent conditioned place preference tests, place preference was suppressed in the drug-treated groups but not saline-treated groups. Results suggest that the amnesic agents, scopolamine and MK-801, disrupted reconsolidation of cocaine-associated contextual memory. In contrast, the mnemonic agent D-cycloserine might have facilitated extinction learning during context exposure in the absence of cocaine. Challenge administration of cocaine reinstated place preference in all groups except the MK-801 group, suggesting that suppression of conditioned response may or may not suppress memory evoked by drug-context reexposure.

Original languageEnglish (US)
Pages (from-to)777-780
Number of pages4
Issue number8
StatePublished - May 2007
Externally publishedYes


  • Cocaine
  • Conditioned place preference
  • Extinction
  • Reconsolidation
  • Reinstatement

ASJC Scopus subject areas

  • Neuroscience(all)


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