Long-term memory of cocaine-associated context

Disruption and reinstatement

Jonathan B. Kelley, Karen L. Anderson, Yossef Itzhak

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Long-term memory of cocaine-associated context was established by conditioned place preference learning. After 1 week, exposure to context in the absence of cocaine (memory retrieval) was paired with one of the following treatments: saline, scopolamine (muscarinic acetylcholine receptor antagonist), dizocilpine (MK-801; noncompetitive N-methyl-D-aspartate antagonist) or D-cycloserine (partial N-methyl-D-aspartate agonist). In subsequent conditioned place preference tests, place preference was suppressed in the drug-treated groups but not saline-treated groups. Results suggest that the amnesic agents, scopolamine and MK-801, disrupted reconsolidation of cocaine-associated contextual memory. In contrast, the mnemonic agent D-cycloserine might have facilitated extinction learning during context exposure in the absence of cocaine. Challenge administration of cocaine reinstated place preference in all groups except the MK-801 group, suggesting that suppression of conditioned response may or may not suppress memory evoked by drug-context reexposure.

Original languageEnglish
Pages (from-to)777-780
Number of pages4
JournalNeuroReport
Volume18
Issue number8
DOIs
StatePublished - May 1 2007

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Long-Term Memory
Cocaine
Dizocilpine Maleate
Cycloserine
Scopolamine Hydrobromide
N-Methylaspartate
Learning
Cholinergic Antagonists
Muscarinic Receptors
Pharmaceutical Preparations

Keywords

  • Cocaine
  • Conditioned place preference
  • Extinction
  • Reconsolidation
  • Reinstatement

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Long-term memory of cocaine-associated context : Disruption and reinstatement. / Kelley, Jonathan B.; Anderson, Karen L.; Itzhak, Yossef.

In: NeuroReport, Vol. 18, No. 8, 01.05.2007, p. 777-780.

Research output: Contribution to journalArticle

Kelley, Jonathan B. ; Anderson, Karen L. ; Itzhak, Yossef. / Long-term memory of cocaine-associated context : Disruption and reinstatement. In: NeuroReport. 2007 ; Vol. 18, No. 8. pp. 777-780.
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