Long-term impact of maternal substance use during pregnancy and extrauterine environmental adversity

Stress hormone levels of preadolescent children

Charles R Bauer, Brittany L. Lambert, Carla M. Bann, Barry M. Lester, Seetha Shankaran, Henrietta S. Bada, Toni M. Whitaker, Linda L. Lagasse, Jane Hammond, Rosemary D. Higgins

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Prenatal cocaine exposure (PCE) is associated with blunted stress responsivity within the extrauterine environment. This study investigated the association between PCE and diurnal salivary cortisol levels in preadolescent children characterized by high biological and/or social risk (n = 725). Saliva samples were collected at their home. Analyses revealed no group differences in basal evening or morning cortisol levels; however, children with higher degrees of PCE exhibited blunted overnight increases in cortisol, controlling for additional risk factors. Race and caregiver depression were also associated with diurnal cortisol patterns. Although repeated PCE may contribute to alterations in the normal or expected stress response later in life, sociodemographic and environmental factors are likewise important in understanding hormone physiology, especially as more time elapses from the PCE. Anticipating the potential long-term medical, developmental, or behavioral effects of an altered ability to mount a normal protective cortisol stress response is essential in optimizing the outcomes of children with PCE.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalPediatric Research
Volume70
Issue number2
DOIs
StatePublished - Aug 1 2011

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Ectopic Pregnancy
Cocaine
Mothers
Hydrocortisone
Hormones
Saliva
Caregivers

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Long-term impact of maternal substance use during pregnancy and extrauterine environmental adversity : Stress hormone levels of preadolescent children. / Bauer, Charles R; Lambert, Brittany L.; Bann, Carla M.; Lester, Barry M.; Shankaran, Seetha; Bada, Henrietta S.; Whitaker, Toni M.; Lagasse, Linda L.; Hammond, Jane; Higgins, Rosemary D.

In: Pediatric Research, Vol. 70, No. 2, 01.08.2011, p. 213-219.

Research output: Contribution to journalArticle

Bauer, CR, Lambert, BL, Bann, CM, Lester, BM, Shankaran, S, Bada, HS, Whitaker, TM, Lagasse, LL, Hammond, J & Higgins, RD 2011, 'Long-term impact of maternal substance use during pregnancy and extrauterine environmental adversity: Stress hormone levels of preadolescent children', Pediatric Research, vol. 70, no. 2, pp. 213-219. https://doi.org/10.1203/PDR.0b013e3182226e26
Bauer, Charles R ; Lambert, Brittany L. ; Bann, Carla M. ; Lester, Barry M. ; Shankaran, Seetha ; Bada, Henrietta S. ; Whitaker, Toni M. ; Lagasse, Linda L. ; Hammond, Jane ; Higgins, Rosemary D. / Long-term impact of maternal substance use during pregnancy and extrauterine environmental adversity : Stress hormone levels of preadolescent children. In: Pediatric Research. 2011 ; Vol. 70, No. 2. pp. 213-219.
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