Long term followup of photorefractive keratectomy with adjuvant use of mitomycin C

Vasilios F. Diakonis, Vardhaman P. Kankariya, George D. Kymionis, Georgios Kounis, George Kontadakis, Eirineos Gkenos, Michael A. Grentzelos, George Hajithanasis, Sonia H Yoo, Ioannis G. Pallikaris

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Abstract

Purpose. To study the long term refractive and visual outcomes of photorefractive keratectomy (PRK) with intraoperative application of mitomycin C (MMC). Methods. This study included 37 eyes who received myopic PRK; after photoablation, a sponge soaked in 0.02% MMC solution was applied in all corneas for 2 minutes. Efficacy, safety, predictability, and stability of PRK MMC were evaluated. Endothelial cell density was evaluated at the last postoperative interval. Results. Mean preoperative spherical equivalent (SEQ) was -6.03±1.87 D (diopters) and reduced to -0.09±0.53 D at the last postoperative examination. Mean followup was 44.73±18.24 months. All the eyes were in the ±1.00 D of attempted versus achieved SEQ at the one-year follow-up interval. Furthermore, 95% of the eyes did not lose lines or gained 1 to 2 lines of CDVA, while 5% lost 1 line. At the third postoperative month, 89% of the eyes either were clear or had trace haze, while 4 eyes had mild haze; by the 12-month postoperative interval, none of the eyes demonstrated haze. Mean endothelial cell density (ECD) at the last postoperative interval was 2658±153 cells/mm2. Conclusions. PRK, with intraoperative use of MMC, demonstrates stable refractive and visual outcomes up to 44 months after surgery.

Original languageEnglish
Article number821920
JournalJournal of Ophthalmology
Volume2014
DOIs
StatePublished - Jan 1 2014

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Photorefractive Keratectomy
Mitomycin
Endothelial Cells
Cell Count
Porifera
Cornea
Safety

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Diakonis, V. F., Kankariya, V. P., Kymionis, G. D., Kounis, G., Kontadakis, G., Gkenos, E., ... Pallikaris, I. G. (2014). Long term followup of photorefractive keratectomy with adjuvant use of mitomycin C. Journal of Ophthalmology, 2014, [821920]. https://doi.org/10.1155/2014/821920

Long term followup of photorefractive keratectomy with adjuvant use of mitomycin C. / Diakonis, Vasilios F.; Kankariya, Vardhaman P.; Kymionis, George D.; Kounis, Georgios; Kontadakis, George; Gkenos, Eirineos; Grentzelos, Michael A.; Hajithanasis, George; Yoo, Sonia H; Pallikaris, Ioannis G.

In: Journal of Ophthalmology, Vol. 2014, 821920, 01.01.2014.

Research output: Contribution to journalArticle

Diakonis, VF, Kankariya, VP, Kymionis, GD, Kounis, G, Kontadakis, G, Gkenos, E, Grentzelos, MA, Hajithanasis, G, Yoo, SH & Pallikaris, IG 2014, 'Long term followup of photorefractive keratectomy with adjuvant use of mitomycin C', Journal of Ophthalmology, vol. 2014, 821920. https://doi.org/10.1155/2014/821920
Diakonis VF, Kankariya VP, Kymionis GD, Kounis G, Kontadakis G, Gkenos E et al. Long term followup of photorefractive keratectomy with adjuvant use of mitomycin C. Journal of Ophthalmology. 2014 Jan 1;2014. 821920. https://doi.org/10.1155/2014/821920
Diakonis, Vasilios F. ; Kankariya, Vardhaman P. ; Kymionis, George D. ; Kounis, Georgios ; Kontadakis, George ; Gkenos, Eirineos ; Grentzelos, Michael A. ; Hajithanasis, George ; Yoo, Sonia H ; Pallikaris, Ioannis G. / Long term followup of photorefractive keratectomy with adjuvant use of mitomycin C. In: Journal of Ophthalmology. 2014 ; Vol. 2014.
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abstract = "Purpose. To study the long term refractive and visual outcomes of photorefractive keratectomy (PRK) with intraoperative application of mitomycin C (MMC). Methods. This study included 37 eyes who received myopic PRK; after photoablation, a sponge soaked in 0.02{\%} MMC solution was applied in all corneas for 2 minutes. Efficacy, safety, predictability, and stability of PRK MMC were evaluated. Endothelial cell density was evaluated at the last postoperative interval. Results. Mean preoperative spherical equivalent (SEQ) was -6.03±1.87 D (diopters) and reduced to -0.09±0.53 D at the last postoperative examination. Mean followup was 44.73±18.24 months. All the eyes were in the ±1.00 D of attempted versus achieved SEQ at the one-year follow-up interval. Furthermore, 95{\%} of the eyes did not lose lines or gained 1 to 2 lines of CDVA, while 5{\%} lost 1 line. At the third postoperative month, 89{\%} of the eyes either were clear or had trace haze, while 4 eyes had mild haze; by the 12-month postoperative interval, none of the eyes demonstrated haze. Mean endothelial cell density (ECD) at the last postoperative interval was 2658±153 cells/mm2. Conclusions. PRK, with intraoperative use of MMC, demonstrates stable refractive and visual outcomes up to 44 months after surgery.",
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