Long term follow-up study of adenomatous hyperplasia in liver cirrhosis

Riccardo Lencioni, D. Caramella, C. Bartolozzi, G. Di Coscio

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The purpose of this study was to investigate the natural history of adenomatous hyperplasia (AH) in liver cirrhosis, which is suspected of being a precancerous condition of hepatocellular carcinoma (HCC). Sixteen patients with 19 histologically proven AH nodules were followed-up over time with ultrasonographic (US) examinations performed every 3-4 months. The biopsy was repeated whenever the volume of the lesion increased, its US pattern changed, or there was a change in the alpha-fetoprotein values. Thirteen out of 19 AH (68.4%) evolved toward HCC after 8-31 months (mean 14.2 months). Malignant transformation was proved in 7/18 AH within 1 year of its initial detection, in 12/15 AH within 2 years, and in 13/14 AH within 4 years. Six AH remained unchanged in size and US pattern for 9-70 months (mean 29.5 months). Long term follow-up of AH confirms that this lesion is a precursor of HCC.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalItalian Journal of Gastroenterology
Volume26
Issue number4
StatePublished - 1994
Externally publishedYes

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Liver Cirrhosis
Hyperplasia
Hepatocellular Carcinoma
Precancerous Conditions
alpha-Fetoproteins
Biopsy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lencioni, R., Caramella, D., Bartolozzi, C., & Di Coscio, G. (1994). Long term follow-up study of adenomatous hyperplasia in liver cirrhosis. Italian Journal of Gastroenterology, 26(4), 163-168.

Long term follow-up study of adenomatous hyperplasia in liver cirrhosis. / Lencioni, Riccardo; Caramella, D.; Bartolozzi, C.; Di Coscio, G.

In: Italian Journal of Gastroenterology, Vol. 26, No. 4, 1994, p. 163-168.

Research output: Contribution to journalArticle

Lencioni, R, Caramella, D, Bartolozzi, C & Di Coscio, G 1994, 'Long term follow-up study of adenomatous hyperplasia in liver cirrhosis', Italian Journal of Gastroenterology, vol. 26, no. 4, pp. 163-168.
Lencioni R, Caramella D, Bartolozzi C, Di Coscio G. Long term follow-up study of adenomatous hyperplasia in liver cirrhosis. Italian Journal of Gastroenterology. 1994;26(4):163-168.
Lencioni, Riccardo ; Caramella, D. ; Bartolozzi, C. ; Di Coscio, G. / Long term follow-up study of adenomatous hyperplasia in liver cirrhosis. In: Italian Journal of Gastroenterology. 1994 ; Vol. 26, No. 4. pp. 163-168.
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