Abstract
The long-term outcome of 20 preterm infants with extremely low birth weight and acute renal failure in the neonatal period was studied retrospectively over an 18-year period. Those with progressive renal disease are compared with those with normal renal function. Current mean age is 7.5±4.6 years (range 3.2-18.5 years). Nine patients showed deterioration in renal function (low GFR group). Increasing proteinuria, as determined by random urine protein/creatinine ratio (Up/c), correlated with deterioration in renal function (r=0.8, P<0.0001). Prominent risk factors for progression were Up/c >0.6 at 1 year of age [100% sensitivity, 75% positive predictive value (PPV), P<0.01], serum creatinine >0.6 mg/dl at 1 year of age (75% sensitivity, 80% PPV, P<0.01), and a tendency to obesity with body mass index >85th percentile (89% sensitivity, PPV 67%, P=0.03). Loss of renal mass and nephrocalcinosis were not prognostic indicators. This report begins to identify important clinical parameters that should lead to closer surveillance and potential treatment interventions for preservation of renal function in a growing population of surviving low birth weight individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 887-893 |
| Number of pages | 7 |
| Journal | Pediatric Nephrology |
| Volume | 18 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2003 |
Fingerprint
Keywords
- Extreme low birth weight
- Hypertension
- Premature nephropathy
- Proteinuria
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health
Cite this
Long-term follow-up of extremely low birth weight infants with neonatal renal failure. / Abitbol, Carolyn; Bauer, Charles R; Montané, Brenda; Chandar, Jayanthi; Duara, Shahnaz; Zilleruelo, Gaston E.
In: Pediatric Nephrology, Vol. 18, No. 9, 01.09.2003, p. 887-893.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long-term follow-up of extremely low birth weight infants with neonatal renal failure
AU - Abitbol, Carolyn
AU - Bauer, Charles R
AU - Montané, Brenda
AU - Chandar, Jayanthi
AU - Duara, Shahnaz
AU - Zilleruelo, Gaston E
PY - 2003/9/1
Y1 - 2003/9/1
N2 - The long-term outcome of 20 preterm infants with extremely low birth weight and acute renal failure in the neonatal period was studied retrospectively over an 18-year period. Those with progressive renal disease are compared with those with normal renal function. Current mean age is 7.5±4.6 years (range 3.2-18.5 years). Nine patients showed deterioration in renal function (low GFR group). Increasing proteinuria, as determined by random urine protein/creatinine ratio (Up/c), correlated with deterioration in renal function (r=0.8, P<0.0001). Prominent risk factors for progression were Up/c >0.6 at 1 year of age [100% sensitivity, 75% positive predictive value (PPV), P<0.01], serum creatinine >0.6 mg/dl at 1 year of age (75% sensitivity, 80% PPV, P<0.01), and a tendency to obesity with body mass index >85th percentile (89% sensitivity, PPV 67%, P=0.03). Loss of renal mass and nephrocalcinosis were not prognostic indicators. This report begins to identify important clinical parameters that should lead to closer surveillance and potential treatment interventions for preservation of renal function in a growing population of surviving low birth weight individuals.
AB - The long-term outcome of 20 preterm infants with extremely low birth weight and acute renal failure in the neonatal period was studied retrospectively over an 18-year period. Those with progressive renal disease are compared with those with normal renal function. Current mean age is 7.5±4.6 years (range 3.2-18.5 years). Nine patients showed deterioration in renal function (low GFR group). Increasing proteinuria, as determined by random urine protein/creatinine ratio (Up/c), correlated with deterioration in renal function (r=0.8, P<0.0001). Prominent risk factors for progression were Up/c >0.6 at 1 year of age [100% sensitivity, 75% positive predictive value (PPV), P<0.01], serum creatinine >0.6 mg/dl at 1 year of age (75% sensitivity, 80% PPV, P<0.01), and a tendency to obesity with body mass index >85th percentile (89% sensitivity, PPV 67%, P=0.03). Loss of renal mass and nephrocalcinosis were not prognostic indicators. This report begins to identify important clinical parameters that should lead to closer surveillance and potential treatment interventions for preservation of renal function in a growing population of surviving low birth weight individuals.
KW - Extreme low birth weight
KW - Hypertension
KW - Premature nephropathy
KW - Proteinuria
UR - http://www.scopus.com/inward/record.url?scp=0141857948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141857948&partnerID=8YFLogxK
U2 - 10.1007/s00467-003-1186-1
DO - 10.1007/s00467-003-1186-1
M3 - Article
C2 - 12836091
AN - SCOPUS:0141857948
VL - 18
SP - 887
EP - 893
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 9
ER -