Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study)

Erin R. Kulick, Gregory A. Wellenius, Joel D. Kaufman, Janet T. Derosa, Patrick L. Kinney, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S. Elkind

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Purpose - Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease. Methods - Participants were 1075 stroke-free individuals aged ≥50 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging. Cross-sectional associations between ambient air pollution and subclinical cerebrovascular disease were analyzed. Results - We found an association between distance to roadway, a proxy for residential exposure to traffic pollution, and white matter hyperintensity volume; however, after adjusting for risk factors, this relationship was no longer present. All other associations between pollutant measures and white matter hyperintensity volume were null. There was no clear association between exposure to air pollutants and subclinical brain infarcts or total cerebral brain volume. Conclusions - We found no evidence that long-term exposure to ambient air pollution is independently associated with subclinical cerebrovascular disease in an urban population-based cohort.

Original languageEnglish (US)
Pages (from-to)1966-1968
Number of pages3
JournalStroke
Volume48
Issue number7
DOIs
StatePublished - Jul 1 2017

Fingerprint

Cerebrovascular Disorders
Air Pollution
Magnetic Resonance Imaging
Air Pollutants
Urban Population
Brain
Proxy
Cardiovascular Diseases
Stroke
Myocardial Infarction
White Matter

Keywords

  • air pollution
  • brain
  • magnetic resonance imaging
  • risk factors
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Kulick, E. R., Wellenius, G. A., Kaufman, J. D., Derosa, J. T., Kinney, P. L., Cheung, Y. K., ... Elkind, M. S. (2017). Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study). Stroke, 48(7), 1966-1968. https://doi.org/10.1161/STROKEAHA.117.016672

Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study). / Kulick, Erin R.; Wellenius, Gregory A.; Kaufman, Joel D.; Derosa, Janet T.; Kinney, Patrick L.; Cheung, Ying Kuen; Wright, Clinton B; Sacco, Ralph L; Elkind, Mitchell S.

In: Stroke, Vol. 48, No. 7, 01.07.2017, p. 1966-1968.

Research output: Contribution to journalArticle

Kulick, ER, Wellenius, GA, Kaufman, JD, Derosa, JT, Kinney, PL, Cheung, YK, Wright, CB, Sacco, RL & Elkind, MS 2017, 'Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study)', Stroke, vol. 48, no. 7, pp. 1966-1968. https://doi.org/10.1161/STROKEAHA.117.016672
Kulick, Erin R. ; Wellenius, Gregory A. ; Kaufman, Joel D. ; Derosa, Janet T. ; Kinney, Patrick L. ; Cheung, Ying Kuen ; Wright, Clinton B ; Sacco, Ralph L ; Elkind, Mitchell S. / Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study). In: Stroke. 2017 ; Vol. 48, No. 7. pp. 1966-1968.
@article{c67cf28dafe548b5bc9faefd0326d094,
title = "Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study)",
abstract = "Background and Purpose - Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease. Methods - Participants were 1075 stroke-free individuals aged ≥50 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging. Cross-sectional associations between ambient air pollution and subclinical cerebrovascular disease were analyzed. Results - We found an association between distance to roadway, a proxy for residential exposure to traffic pollution, and white matter hyperintensity volume; however, after adjusting for risk factors, this relationship was no longer present. All other associations between pollutant measures and white matter hyperintensity volume were null. There was no clear association between exposure to air pollutants and subclinical brain infarcts or total cerebral brain volume. Conclusions - We found no evidence that long-term exposure to ambient air pollution is independently associated with subclinical cerebrovascular disease in an urban population-based cohort.",
keywords = "air pollution, brain, magnetic resonance imaging, risk factors, stroke",
author = "Kulick, {Erin R.} and Wellenius, {Gregory A.} and Kaufman, {Joel D.} and Derosa, {Janet T.} and Kinney, {Patrick L.} and Cheung, {Ying Kuen} and Wright, {Clinton B} and Sacco, {Ralph L} and Elkind, {Mitchell S.}",
year = "2017",
month = "7",
day = "1",
doi = "10.1161/STROKEAHA.117.016672",
language = "English (US)",
volume = "48",
pages = "1966--1968",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study)

AU - Kulick, Erin R.

AU - Wellenius, Gregory A.

AU - Kaufman, Joel D.

AU - Derosa, Janet T.

AU - Kinney, Patrick L.

AU - Cheung, Ying Kuen

AU - Wright, Clinton B

AU - Sacco, Ralph L

AU - Elkind, Mitchell S.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background and Purpose - Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease. Methods - Participants were 1075 stroke-free individuals aged ≥50 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging. Cross-sectional associations between ambient air pollution and subclinical cerebrovascular disease were analyzed. Results - We found an association between distance to roadway, a proxy for residential exposure to traffic pollution, and white matter hyperintensity volume; however, after adjusting for risk factors, this relationship was no longer present. All other associations between pollutant measures and white matter hyperintensity volume were null. There was no clear association between exposure to air pollutants and subclinical brain infarcts or total cerebral brain volume. Conclusions - We found no evidence that long-term exposure to ambient air pollution is independently associated with subclinical cerebrovascular disease in an urban population-based cohort.

AB - Background and Purpose - Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease. Methods - Participants were 1075 stroke-free individuals aged ≥50 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging. Cross-sectional associations between ambient air pollution and subclinical cerebrovascular disease were analyzed. Results - We found an association between distance to roadway, a proxy for residential exposure to traffic pollution, and white matter hyperintensity volume; however, after adjusting for risk factors, this relationship was no longer present. All other associations between pollutant measures and white matter hyperintensity volume were null. There was no clear association between exposure to air pollutants and subclinical brain infarcts or total cerebral brain volume. Conclusions - We found no evidence that long-term exposure to ambient air pollution is independently associated with subclinical cerebrovascular disease in an urban population-based cohort.

KW - air pollution

KW - brain

KW - magnetic resonance imaging

KW - risk factors

KW - stroke

UR - http://www.scopus.com/inward/record.url?scp=85021451803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021451803&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.117.016672

DO - 10.1161/STROKEAHA.117.016672

M3 - Article

VL - 48

SP - 1966

EP - 1968

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 7

ER -