Abstract
Chronic electrophysiological abnormalities in cats surviving experimental myocardial infarction (MI) were recorded 1 week to 6 months following single-stage ligation of multiple distal tributaries of the left coronary artery system. Sixteen of 32 long-term MI cats (50%) had a propensity to ventricular ectopic activity (VEA), as established by at least one of three criteria : (1) spontaneous VEA on electrocardiogram (ECG) prior to death (8 of 32 cats; 25%); (2) accelerated ventricular escape rhythms during vagal stimulation (7 of 21; 33%); and (3) rapid automatic activity of the isolated left ventricle in tissue bath (11 of 32; 34%). Cellular electrophysiological abnormalities in surviving subendocardial tissue overlying the MI scar were recorded in 29 of 32 preparations (91%). Focal areas of action potential (AP) abnormalities were interspersed between areas of normal activity. AP abnormalities were of three types: (1) prolongation of AP duration; (2) shortening of AP duration; and (3) low amplitude action potentials. Type 1 abnormalities were recorded most commonly between 1 week and 1 month after MI, and rarely were recorded later. Type 2 abnormalities began to appear 1 1/2 months after MI and were most common at 3-6 months. Type 3 abnormalities were recorded at any stage. At 3 months after MI and beyond, surviving cells were histologically normal, despite continued AP abnormalities and propensity to VEA. The data demonstrate a persistence of deranged cellular electrophysiology for up to 6 months after MI.
| Original language | English |
|---|---|
| Pages (from-to) | 73-84 |
| Number of pages | 12 |
| Journal | Circulation Research |
| Volume | 41 |
| Issue number | 1 |
| State | Published - Dec 1 1977 |
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ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Long term electrophysiological abnormalities resulting from experimental myocardial infarction in cats. / Myerburg, Robert J; Gelband, H.; Nilsson, K.; Sung, R. J.; Thurer, Richard J; Morales, Azorides R; Bassett, A. L.
In: Circulation Research, Vol. 41, No. 1, 01.12.1977, p. 73-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Long term electrophysiological abnormalities resulting from experimental myocardial infarction in cats
AU - Myerburg, Robert J
AU - Gelband, H.
AU - Nilsson, K.
AU - Sung, R. J.
AU - Thurer, Richard J
AU - Morales, Azorides R
AU - Bassett, A. L.
PY - 1977/12/1
Y1 - 1977/12/1
N2 - Chronic electrophysiological abnormalities in cats surviving experimental myocardial infarction (MI) were recorded 1 week to 6 months following single-stage ligation of multiple distal tributaries of the left coronary artery system. Sixteen of 32 long-term MI cats (50%) had a propensity to ventricular ectopic activity (VEA), as established by at least one of three criteria : (1) spontaneous VEA on electrocardiogram (ECG) prior to death (8 of 32 cats; 25%); (2) accelerated ventricular escape rhythms during vagal stimulation (7 of 21; 33%); and (3) rapid automatic activity of the isolated left ventricle in tissue bath (11 of 32; 34%). Cellular electrophysiological abnormalities in surviving subendocardial tissue overlying the MI scar were recorded in 29 of 32 preparations (91%). Focal areas of action potential (AP) abnormalities were interspersed between areas of normal activity. AP abnormalities were of three types: (1) prolongation of AP duration; (2) shortening of AP duration; and (3) low amplitude action potentials. Type 1 abnormalities were recorded most commonly between 1 week and 1 month after MI, and rarely were recorded later. Type 2 abnormalities began to appear 1 1/2 months after MI and were most common at 3-6 months. Type 3 abnormalities were recorded at any stage. At 3 months after MI and beyond, surviving cells were histologically normal, despite continued AP abnormalities and propensity to VEA. The data demonstrate a persistence of deranged cellular electrophysiology for up to 6 months after MI.
AB - Chronic electrophysiological abnormalities in cats surviving experimental myocardial infarction (MI) were recorded 1 week to 6 months following single-stage ligation of multiple distal tributaries of the left coronary artery system. Sixteen of 32 long-term MI cats (50%) had a propensity to ventricular ectopic activity (VEA), as established by at least one of three criteria : (1) spontaneous VEA on electrocardiogram (ECG) prior to death (8 of 32 cats; 25%); (2) accelerated ventricular escape rhythms during vagal stimulation (7 of 21; 33%); and (3) rapid automatic activity of the isolated left ventricle in tissue bath (11 of 32; 34%). Cellular electrophysiological abnormalities in surviving subendocardial tissue overlying the MI scar were recorded in 29 of 32 preparations (91%). Focal areas of action potential (AP) abnormalities were interspersed between areas of normal activity. AP abnormalities were of three types: (1) prolongation of AP duration; (2) shortening of AP duration; and (3) low amplitude action potentials. Type 1 abnormalities were recorded most commonly between 1 week and 1 month after MI, and rarely were recorded later. Type 2 abnormalities began to appear 1 1/2 months after MI and were most common at 3-6 months. Type 3 abnormalities were recorded at any stage. At 3 months after MI and beyond, surviving cells were histologically normal, despite continued AP abnormalities and propensity to VEA. The data demonstrate a persistence of deranged cellular electrophysiology for up to 6 months after MI.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017641936&partnerID=8YFLogxK
M3 - Article
C2 - 862146
AN - SCOPUS:0017641936
VL - 41
SP - 73
EP - 84
JO - Circulation Research
JF - Circulation Research
SN - 0009-7330
IS - 1
ER -