Long term electrophysiological abnormalities resulting from experimental myocardial infarction in cats

Robert J Myerburg, H. Gelband, K. Nilsson, R. J. Sung, Richard J Thurer, Azorides R Morales, A. L. Bassett

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Abstract

Chronic electrophysiological abnormalities in cats surviving experimental myocardial infarction (MI) were recorded 1 week to 6 months following single-stage ligation of multiple distal tributaries of the left coronary artery system. Sixteen of 32 long-term MI cats (50%) had a propensity to ventricular ectopic activity (VEA), as established by at least one of three criteria : (1) spontaneous VEA on electrocardiogram (ECG) prior to death (8 of 32 cats; 25%); (2) accelerated ventricular escape rhythms during vagal stimulation (7 of 21; 33%); and (3) rapid automatic activity of the isolated left ventricle in tissue bath (11 of 32; 34%). Cellular electrophysiological abnormalities in surviving subendocardial tissue overlying the MI scar were recorded in 29 of 32 preparations (91%). Focal areas of action potential (AP) abnormalities were interspersed between areas of normal activity. AP abnormalities were of three types: (1) prolongation of AP duration; (2) shortening of AP duration; and (3) low amplitude action potentials. Type 1 abnormalities were recorded most commonly between 1 week and 1 month after MI, and rarely were recorded later. Type 2 abnormalities began to appear 1 1/2 months after MI and were most common at 3-6 months. Type 3 abnormalities were recorded at any stage. At 3 months after MI and beyond, surviving cells were histologically normal, despite continued AP abnormalities and propensity to VEA. The data demonstrate a persistence of deranged cellular electrophysiology for up to 6 months after MI.

Original languageEnglish
Pages (from-to)73-84
Number of pages12
JournalCirculation Research
Volume41
Issue number1
StatePublished - Dec 1 1977

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Cats
Action Potentials
Myocardial Infarction
Electrophysiology
Baths
Heart Ventricles
Cicatrix
Ligation
Coronary Vessels
Electrocardiography

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Myerburg, R. J., Gelband, H., Nilsson, K., Sung, R. J., Thurer, R. J., Morales, A. R., & Bassett, A. L. (1977). Long term electrophysiological abnormalities resulting from experimental myocardial infarction in cats. Circulation Research, 41(1), 73-84.

Long term electrophysiological abnormalities resulting from experimental myocardial infarction in cats. / Myerburg, Robert J; Gelband, H.; Nilsson, K.; Sung, R. J.; Thurer, Richard J; Morales, Azorides R; Bassett, A. L.

In: Circulation Research, Vol. 41, No. 1, 01.12.1977, p. 73-84.

Research output: Contribution to journalArticle

Myerburg, RJ, Gelband, H, Nilsson, K, Sung, RJ, Thurer, RJ, Morales, AR & Bassett, AL 1977, 'Long term electrophysiological abnormalities resulting from experimental myocardial infarction in cats', Circulation Research, vol. 41, no. 1, pp. 73-84.
Myerburg RJ, Gelband H, Nilsson K, Sung RJ, Thurer RJ, Morales AR et al. Long term electrophysiological abnormalities resulting from experimental myocardial infarction in cats. Circulation Research. 1977 Dec 1;41(1):73-84.
Myerburg, Robert J ; Gelband, H. ; Nilsson, K. ; Sung, R. J. ; Thurer, Richard J ; Morales, Azorides R ; Bassett, A. L. / Long term electrophysiological abnormalities resulting from experimental myocardial infarction in cats. In: Circulation Research. 1977 ; Vol. 41, No. 1. pp. 73-84.
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