Long-term complete regression of nodal marginal zone lymphoma transformed into diffuse large B-cell lymphoma with highly active antiretroviral therapy alone in human immunodeficiency virus infection

Ioannis G. Baraboutis, Leonidas Marinos, Lazaros J. Lekakis, Vasilios Papastamopoulos, Ourania Georgiou, Eleftheria P. Tsagalou, Phoeve Rondogianni, John Apostolidis, Theodora Papadaki, Athanasios T. Skoutelis

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Since the introduction of combination antiretroviral therapy (cART), there has been a decrease in the incidence of non-Hodgkin lymphoma among the HIV-infected population and also significantly improved survival rates. We describe a remarkable case of a HIV-infected patient whose large B-cell lymphoma, most likely arising by transformation of a nodal marginal zone lymphoma, completely regressed with the use of cART alone. He remained disease-free for almost 3 years and he finally died from presumed flare up of his lymphoma. There are very few cases of spontaneous regression of lymphomas with cART alone in the HIV population. This is an extreme example of the significance of cART in improving survival in HIV-non-Hodgkin lymphoma and changing the face of the HIV epidemic in general.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume338
Issue number6
DOIs
StatePublished - Dec 2009
Externally publishedYes

Keywords

  • Antiretroviral therapy
  • Diffuse large B-cell lymphoma
  • HIV infection
  • Nodal marginal zone lymphoma
  • Spontaneous regression

ASJC Scopus subject areas

  • Medicine(all)

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