Long noncoding transcriptome in chronic obstructive pulmonary disease

Dinesh Devadoss, Christopher Long, Raymond J. Langley, Marko Manevski, Madhavan Nair, Michael A. Campos, Glen Borchert, Irfan Rahman, Hitendra S. Chand

Research output: Contribution to journalReview article

Abstract

Chronic airway inflammation from recurring exposures to noxious environmental stimuli results in a progressive and irreversible airflow limitation and the lung parenchymal damage that characterizes chronic obstructive pulmonary disease (COPD). The large variability observed in the onset and progression of COPD is primarily driven by complex gene-environment interactions. The transcriptomic and epigenetic memory potential of lung epithelial and innate immune cells drive responses, such as mucus hyperreactivity and airway remodeling, that are tightly regulated by various molecular mechanisms, for which several candidate susceptibility genes have been described. However, the recently described noncoding RNA species, in particular the long noncoding RNAs, may also have an important role in modulating pulmonary responses to chronic inhalation of toxic substances and the development of COPD. This review outlines the features of long noncoding RNAs that have been implicated in regulating the airway inflammatory responses to cigarette smoke exposure and their possible association with COPD pathogenesis. As COPD continues to debilitate the increasingly aging population and contribute to higher morbidity and mortality rates worldwide, the search for better biomarkers and alternative therapeutic options is pivotal.

Original languageEnglish (US)
Pages (from-to)678-688
Number of pages11
JournalAmerican journal of respiratory cell and molecular biology
Volume61
Issue number6
DOIs
StatePublished - Jan 1 2019

Fingerprint

Pulmonary diseases
Transcriptome
Chronic Obstructive Pulmonary Disease
Long Noncoding RNA
Lung
Genes
Airway Remodeling
Gene-Environment Interaction
Untranslated RNA
Poisons
Biomarkers
Mucus
Epigenomics
Smoke
Tobacco Products
Inhalation
Aging of materials
Association reactions
Inflammation
Morbidity

Keywords

  • Cigarette smoke
  • Inflammation
  • LncRNAs
  • Mitochondria
  • Senescence

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

Cite this

Long noncoding transcriptome in chronic obstructive pulmonary disease. / Devadoss, Dinesh; Long, Christopher; Langley, Raymond J.; Manevski, Marko; Nair, Madhavan; Campos, Michael A.; Borchert, Glen; Rahman, Irfan; Chand, Hitendra S.

In: American journal of respiratory cell and molecular biology, Vol. 61, No. 6, 01.01.2019, p. 678-688.

Research output: Contribution to journalReview article

Devadoss, D, Long, C, Langley, RJ, Manevski, M, Nair, M, Campos, MA, Borchert, G, Rahman, I & Chand, HS 2019, 'Long noncoding transcriptome in chronic obstructive pulmonary disease', American journal of respiratory cell and molecular biology, vol. 61, no. 6, pp. 678-688. https://doi.org/10.1165/rcmb.2019-0184TR
Devadoss, Dinesh ; Long, Christopher ; Langley, Raymond J. ; Manevski, Marko ; Nair, Madhavan ; Campos, Michael A. ; Borchert, Glen ; Rahman, Irfan ; Chand, Hitendra S. / Long noncoding transcriptome in chronic obstructive pulmonary disease. In: American journal of respiratory cell and molecular biology. 2019 ; Vol. 61, No. 6. pp. 678-688.
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