Localizing value of ictal SPECT is comparable to MRI and EEG in children with focal cortical dysplasia

Pavel Krsek, Martin Kudr, Alena Jahodova, Vladimir Komarek, Bruno Maton, Stephen Malone, Ian Miller, Prasanna Jayakar, Trevor Resnick, Michael Duchowny

Research output: Contribution to journalArticle

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Abstract

Purpose To assess the predictive value of ictal single-photon emission computed tomography (SPECT) for outcome after excisional epilepsy surgery in a large population of children with focal cortical dysplasia (FCD). Methods One hundred seventy-three ictal SPECT studies in 106 children with histologically proven FCD were retrospectively analyzed. The extent and location of ictal hyperperfusion and completeness of surgical removal were assessed. Completeness of resection of epileptogenic regions defined by ictal SPECT, electroencephalography (EEG), and magnetic resonance imaging (MRI) were compared and correlated with postoperative seizure outcome. In addition, subcortical activation of the cerebellum, basal ganglia, and thalamus were analyzed. Key Findings The extent of hyperperfusion was focal or lobar in 58%, whereas multilobar activations occurred in only 32%; hemispheric or bilateral findings were rare. Favorable postsurgical seizure outcome was achieved in 67% patients with nonlocalized SPECT findings, 45% with nonresected ictal hyperperfusion, 36% with partially resected ictal hyperperfusion, and 86% when the zone of ictal hyperperfusion was completely resected (p = 0.000198). The favorable postsurgical outcome after complete removal of the SPECT hyperperfusion zone surpassed the 75% rate of seizure freedom in patients with removal of MRI/EEG-defined epileptogenic region. A similar predictive value of ictal SPECT for seizure outcome was found in nonoperated patients and subjects who were undergoing reoperation. Subcortical activation conferred no predictive value. Significance Ictal SPECT helps to define the epileptogenic zone in a high proportion of children with FCD undergoing surgical evaluation. Complete removal of both SPECT and MRI/EEG-defined regions is a strong predictor of surgical success and has important implications for surgical planning.

Original languageEnglish
Pages (from-to)351-358
Number of pages8
JournalEpilepsia
Volume54
Issue number2
DOIs
StatePublished - Feb 1 2013

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Malformations of Cortical Development
Single-Photon Emission-Computed Tomography
Electroencephalography
Stroke
Magnetic Resonance Imaging
Seizures
Basal Ganglia
Thalamus
Reoperation
Cerebellum
Epilepsy

Keywords

  • Completeness of resection
  • Epilepsy surgery
  • Focal cortical dysplasia
  • Ictal SPECT
  • Outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Krsek, P., Kudr, M., Jahodova, A., Komarek, V., Maton, B., Malone, S., ... Duchowny, M. (2013). Localizing value of ictal SPECT is comparable to MRI and EEG in children with focal cortical dysplasia. Epilepsia, 54(2), 351-358. https://doi.org/10.1111/epi.12059

Localizing value of ictal SPECT is comparable to MRI and EEG in children with focal cortical dysplasia. / Krsek, Pavel; Kudr, Martin; Jahodova, Alena; Komarek, Vladimir; Maton, Bruno; Malone, Stephen; Miller, Ian; Jayakar, Prasanna; Resnick, Trevor; Duchowny, Michael.

In: Epilepsia, Vol. 54, No. 2, 01.02.2013, p. 351-358.

Research output: Contribution to journalArticle

Krsek, P, Kudr, M, Jahodova, A, Komarek, V, Maton, B, Malone, S, Miller, I, Jayakar, P, Resnick, T & Duchowny, M 2013, 'Localizing value of ictal SPECT is comparable to MRI and EEG in children with focal cortical dysplasia', Epilepsia, vol. 54, no. 2, pp. 351-358. https://doi.org/10.1111/epi.12059
Krsek, Pavel ; Kudr, Martin ; Jahodova, Alena ; Komarek, Vladimir ; Maton, Bruno ; Malone, Stephen ; Miller, Ian ; Jayakar, Prasanna ; Resnick, Trevor ; Duchowny, Michael. / Localizing value of ictal SPECT is comparable to MRI and EEG in children with focal cortical dysplasia. In: Epilepsia. 2013 ; Vol. 54, No. 2. pp. 351-358.
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abstract = "Purpose To assess the predictive value of ictal single-photon emission computed tomography (SPECT) for outcome after excisional epilepsy surgery in a large population of children with focal cortical dysplasia (FCD). Methods One hundred seventy-three ictal SPECT studies in 106 children with histologically proven FCD were retrospectively analyzed. The extent and location of ictal hyperperfusion and completeness of surgical removal were assessed. Completeness of resection of epileptogenic regions defined by ictal SPECT, electroencephalography (EEG), and magnetic resonance imaging (MRI) were compared and correlated with postoperative seizure outcome. In addition, subcortical activation of the cerebellum, basal ganglia, and thalamus were analyzed. Key Findings The extent of hyperperfusion was focal or lobar in 58{\%}, whereas multilobar activations occurred in only 32{\%}; hemispheric or bilateral findings were rare. Favorable postsurgical seizure outcome was achieved in 67{\%} patients with nonlocalized SPECT findings, 45{\%} with nonresected ictal hyperperfusion, 36{\%} with partially resected ictal hyperperfusion, and 86{\%} when the zone of ictal hyperperfusion was completely resected (p = 0.000198). The favorable postsurgical outcome after complete removal of the SPECT hyperperfusion zone surpassed the 75{\%} rate of seizure freedom in patients with removal of MRI/EEG-defined epileptogenic region. A similar predictive value of ictal SPECT for seizure outcome was found in nonoperated patients and subjects who were undergoing reoperation. Subcortical activation conferred no predictive value. Significance Ictal SPECT helps to define the epileptogenic zone in a high proportion of children with FCD undergoing surgical evaluation. Complete removal of both SPECT and MRI/EEG-defined regions is a strong predictor of surgical success and has important implications for surgical planning.",
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AU - Kudr, Martin

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AU - Maton, Bruno

AU - Malone, Stephen

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AU - Jayakar, Prasanna

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AB - Purpose To assess the predictive value of ictal single-photon emission computed tomography (SPECT) for outcome after excisional epilepsy surgery in a large population of children with focal cortical dysplasia (FCD). Methods One hundred seventy-three ictal SPECT studies in 106 children with histologically proven FCD were retrospectively analyzed. The extent and location of ictal hyperperfusion and completeness of surgical removal were assessed. Completeness of resection of epileptogenic regions defined by ictal SPECT, electroencephalography (EEG), and magnetic resonance imaging (MRI) were compared and correlated with postoperative seizure outcome. In addition, subcortical activation of the cerebellum, basal ganglia, and thalamus were analyzed. Key Findings The extent of hyperperfusion was focal or lobar in 58%, whereas multilobar activations occurred in only 32%; hemispheric or bilateral findings were rare. Favorable postsurgical seizure outcome was achieved in 67% patients with nonlocalized SPECT findings, 45% with nonresected ictal hyperperfusion, 36% with partially resected ictal hyperperfusion, and 86% when the zone of ictal hyperperfusion was completely resected (p = 0.000198). The favorable postsurgical outcome after complete removal of the SPECT hyperperfusion zone surpassed the 75% rate of seizure freedom in patients with removal of MRI/EEG-defined epileptogenic region. A similar predictive value of ictal SPECT for seizure outcome was found in nonoperated patients and subjects who were undergoing reoperation. Subcortical activation conferred no predictive value. Significance Ictal SPECT helps to define the epileptogenic zone in a high proportion of children with FCD undergoing surgical evaluation. Complete removal of both SPECT and MRI/EEG-defined regions is a strong predictor of surgical success and has important implications for surgical planning.

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