Localized two-dimensional shift correlated MR spectroscopy of human brain

M. Albert Thomas, Kenneth Yue, Nader Binesh, Pablo Davanzo, Anand Kumar, Benjamin Siegel, Mark Frye, John Curran, Robert Lufkin, Paul Martin, Barry Guze

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

A two-dimensional (2D) chemical shift correlated MR spectroscopic (COSY) sequence integrated into a new volume localization technique (90°-180°-90°) is proposed for whole-body MR spectroscopy (MRS). Using the product operator formalism, a theoretical calculation of the volume localization as well as the coherence transfer efficiencies in 2D MRS is presented. Phantom model solutions were used to test and optimize the efficiency of the proposed sequence. A combination of different MRI transmit/receive RF coils was used: a head MRI coil and a 3″ surface coil receive combined with a body coil transmit. The J cross-peaks due to N-acetyl aspartate (NAA), glutamate/glutamine (Glx), myo-inositol (ml), creatine (Cr), choline (Ch), aspartate (Asp), γ-aminobutyrate (GABA), taurine (Tau), glutathione (GSH), threonine (Thr), and macromolecules (MM) were identified. The cross-peak intensities excited by the proposed 2D sequence were asymmetric with respect to the diagonal peaks. Localized COSY (L-COSY) spectra of cerebral prefrontal and occipital gray/white matter regions in 15 healthy controls are presented.

Original languageEnglish
Pages (from-to)58-67
Number of pages10
JournalMagnetic Resonance in Medicine
Volume46
Issue number1
DOIs
StatePublished - Jul 11 2001
Externally publishedYes

Fingerprint

Magnetic Resonance Spectroscopy
Aminobutyrates
Creatine
Taurine
Brain
Inositol
Threonine
Choline
Glutamine
Aspartic Acid
gamma-Aminobutyric Acid
Glutathione
Glutamic Acid
Head
White Matter
N-acetylaspartate
Gray Matter

Keywords

  • H MR spectroscopy
  • Human brain
  • Localized two-dimensional COSY

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Albert Thomas, M., Yue, K., Binesh, N., Davanzo, P., Kumar, A., Siegel, B., ... Guze, B. (2001). Localized two-dimensional shift correlated MR spectroscopy of human brain. Magnetic Resonance in Medicine, 46(1), 58-67. https://doi.org/10.1002/mrm.1160

Localized two-dimensional shift correlated MR spectroscopy of human brain. / Albert Thomas, M.; Yue, Kenneth; Binesh, Nader; Davanzo, Pablo; Kumar, Anand; Siegel, Benjamin; Frye, Mark; Curran, John; Lufkin, Robert; Martin, Paul; Guze, Barry.

In: Magnetic Resonance in Medicine, Vol. 46, No. 1, 11.07.2001, p. 58-67.

Research output: Contribution to journalArticle

Albert Thomas, M, Yue, K, Binesh, N, Davanzo, P, Kumar, A, Siegel, B, Frye, M, Curran, J, Lufkin, R, Martin, P & Guze, B 2001, 'Localized two-dimensional shift correlated MR spectroscopy of human brain', Magnetic Resonance in Medicine, vol. 46, no. 1, pp. 58-67. https://doi.org/10.1002/mrm.1160
Albert Thomas M, Yue K, Binesh N, Davanzo P, Kumar A, Siegel B et al. Localized two-dimensional shift correlated MR spectroscopy of human brain. Magnetic Resonance in Medicine. 2001 Jul 11;46(1):58-67. https://doi.org/10.1002/mrm.1160
Albert Thomas, M. ; Yue, Kenneth ; Binesh, Nader ; Davanzo, Pablo ; Kumar, Anand ; Siegel, Benjamin ; Frye, Mark ; Curran, John ; Lufkin, Robert ; Martin, Paul ; Guze, Barry. / Localized two-dimensional shift correlated MR spectroscopy of human brain. In: Magnetic Resonance in Medicine. 2001 ; Vol. 46, No. 1. pp. 58-67.
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