Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

Yao-Shan Fan, R. Sasi, C. Lee, J. S D Winter, M. R. Waterman, C. C. Lin

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

Original languageEnglish
Pages (from-to)1110-1111
Number of pages2
JournalGenomics
Volume14
Issue number4
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Chromosome Banding
Steroid 17-alpha-Hydroxylase
Cytochromes
Fluorescence In Situ Hybridization
Chromosomes, Human, Pair 10
Genes
Hybrid Cells
Mixed Function Oxygenases
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding. / Fan, Yao-Shan; Sasi, R.; Lee, C.; Winter, J. S D; Waterman, M. R.; Lin, C. C.

In: Genomics, Vol. 14, No. 4, 01.01.1992, p. 1110-1111.

Research output: Contribution to journalArticle

Fan, Yao-Shan ; Sasi, R. ; Lee, C. ; Winter, J. S D ; Waterman, M. R. ; Lin, C. C. / Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding. In: Genomics. 1992 ; Vol. 14, No. 4. pp. 1110-1111.
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