Abstract
The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.
| Original language | English |
|---|---|
| Pages (from-to) | 1110-1111 |
| Number of pages | 2 |
| Journal | Genomics |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
Cite this
Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding. / Fan, Yao-Shan; Sasi, R.; Lee, C.; Winter, J. S D; Waterman, M. R.; Lin, C. C.
In: Genomics, Vol. 14, No. 4, 01.01.1992, p. 1110-1111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding
AU - Fan, Yao-Shan
AU - Sasi, R.
AU - Lee, C.
AU - Winter, J. S D
AU - Waterman, M. R.
AU - Lin, C. C.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.
AB - The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.
UR - http://www.scopus.com/inward/record.url?scp=0027059164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027059164&partnerID=8YFLogxK
U2 - 10.1016/S0888-7543(05)80140-5
DO - 10.1016/S0888-7543(05)80140-5
M3 - Article
C2 - 1478654
AN - SCOPUS:0027059164
VL - 14
SP - 1110
EP - 1111
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 4
ER -