Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

Y. S. Fan, R. Sasi, C. Lee, J. S.D. Winter, M. R. Waterman, C. C. Lin

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

Original languageEnglish (US)
Pages (from-to)1110-1111
Number of pages2
JournalGenomics
Volume14
Issue number4
DOIs
StatePublished - Dec 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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