Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

Y. S. Fan; R. Sasi; C. Lee; J. S.D. Winter; M. R. Waterman; C. C. Lin

doi:10.1016/S0888-7543(05)80140-5

Localization of the human CYP17 gene (cytochrome P450_17α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

Y. S. Fan, R. Sasi, C. Lee, J. S.D. Winter, M. R. Waterman, C. C. Lin

Research output: Contribution to journal › Article › peer-review

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Abstract

The gene for human P450_17α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

Original language	English (US)
Pages (from-to)	1110-1111
Number of pages	2
Journal	Genomics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/S0888-7543(05)80140-5
State	Published - Dec 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1016/S0888-7543(05)80140-5

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title = "Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding",

abstract = "The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.",

author = "Fan, {Y. S.} and R. Sasi and C. Lee and Winter, {J. S.D.} and Waterman, {M. R.} and Lin, {C. C.}",

note = "Funding Information: This study was supported in part by an NSERC of Canada grant to C.C.L., an Alberta Heritage Fund for Medical Research (AHFMR) Grant to J.S.D.W., and an AHFMR fellowship grant to Y.S.F.",

year = "1992",

month = dec,

doi = "10.1016/S0888-7543(05)80140-5",

language = "English (US)",

volume = "14",

pages = "1110--1111",

journal = "Genomics",

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T1 - Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

AU - Fan, Y. S.

AU - Sasi, R.

AU - Lee, C.

AU - Winter, J. S.D.

AU - Waterman, M. R.

AU - Lin, C. C.

N1 - Funding Information: This study was supported in part by an NSERC of Canada grant to C.C.L., an Alberta Heritage Fund for Medical Research (AHFMR) Grant to J.S.D.W., and an AHFMR fellowship grant to Y.S.F.

PY - 1992/12

Y1 - 1992/12

N2 - The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

AB - The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

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Localization of the human CYP17 gene (cytochrome P450_17α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

Abstract

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