Abstract
The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1110-1111 |
| Number of pages | 2 |
| Journal | Genomics |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics
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Fan, Y. S., Sasi, R., Lee, C., Winter, J. S. D., Waterman, M. R., & Lin, C. C. (1992). Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding. Genomics, 14(4), 1110-1111. https://doi.org/10.1016/S0888-7543(05)80140-5