Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

Y. S. Fan; R. Sasi; C. Lee; J. S.D. Winter; M. R. Waterman; C. C. Lin

doi:10.1016/S0888-7543(05)80140-5

Localization of the human CYP17 gene (cytochrome P450_17α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

Y. S. Fan, R. Sasi, C. Lee, J. S.D. Winter, M. R. Waterman, C. C. Lin

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

The gene for human P450_17α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

Original language	English (US)
Pages (from-to)	1110-1111
Number of pages	2
Journal	Genomics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/S0888-7543(05)80140-5
State	Published - Dec 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

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title = "Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding",

abstract = "The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.",

author = "Fan, {Y. S.} and R. Sasi and C. Lee and Winter, {J. S.D.} and Waterman, {M. R.} and Lin, {C. C.}",

year = "1992",

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doi = "10.1016/S0888-7543(05)80140-5",

language = "English (US)",

volume = "14",

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journal = "Genomics",

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T1 - Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

AU - Fan, Y. S.

AU - Sasi, R.

AU - Lee, C.

AU - Winter, J. S.D.

AU - Waterman, M. R.

AU - Lin, C. C.

PY - 1992/12

Y1 - 1992/12

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AB - The gene for human P45017α (CYP17) was previously mapped to chromosome 10 through analysis of somatic cell hybrids. Using a modified procedure of fluorescence in situ hybridization, this gene has now been visualized on simultaneously banded chromosomes and localized to a specific subband of chromosome 10 at q24.3. This precise assignment may facilitate the understanding of the molecular basis of 17α-hydroxylase/17,20-lyase deficiency and the evolution of the CYP superfamily of genes.

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