Localization of the extracellular end of the voltage sensor S4 in a potassium channel

Fredrik Elinder, Peter Århem, Hans P Larsson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The opening and closing of the pore of voltage-gated ion channels is the basis for the nervous impulse. These conformational changes are triggered by the movement of an intrinsic voltage sensor, the fourth transmembrane segment, S4. The central problem of how the movement of S4 is coupled to channel opening and where S4 is located in relation to the pore is still unsolved. Here, we estimate the position of the extracellular end of S4 in the Shaker potassium channel by analyzing the electrostatic effect of introduced charges in the pore-forming motif (S5-S6). We also present a three-dimensional model for all transmembrane segments. Knowledge of this structure is essential for the attempts to understand how voltage opens these channels.

Original languageEnglish
Pages (from-to)1802-1809
Number of pages8
JournalBiophysical Journal
Volume80
Issue number4
StatePublished - Apr 19 2001
Externally publishedYes

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Shaker Superfamily of Potassium Channels
S 6
Potassium Channels
Static Electricity
Ion Channels

ASJC Scopus subject areas

  • Biophysics

Cite this

Localization of the extracellular end of the voltage sensor S4 in a potassium channel. / Elinder, Fredrik; Århem, Peter; Larsson, Hans P.

In: Biophysical Journal, Vol. 80, No. 4, 19.04.2001, p. 1802-1809.

Research output: Contribution to journalArticle

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