Localization of the extracellular end of the voltage sensor S4 in a potassium channel

Fredrik Elinder, Peter Århem, H. Peter Larsson

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The opening and closing of the pore of voltage-gated ion channels is the basis for the nervous impulse. These conformational changes are triggered by the movement of an intrinsic voltage sensor, the fourth transmembrane segment, S4. The central problem of how the movement of S4 is coupled to channel opening and where S4 is located in relation to the pore is still unsolved. Here, we estimate the position of the extracellular end of S4 in the Shaker potassium channel by analyzing the electrostatic effect of introduced charges in the pore-forming motif (S5-S6). We also present a three-dimensional model for all transmembrane segments. Knowledge of this structure is essential for the attempts to understand how voltage opens these channels.

Original languageEnglish (US)
Pages (from-to)1802-1809
Number of pages8
JournalBiophysical journal
Volume80
Issue number4
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Biophysics

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