Abstract
Nerve growth factor (NGF) receptors were visualized in the basal human forebrain using an immunohistochemial procedure with a monoclonal antibody previously shown to recognize human melanoma cell NGF receptors. The receptors were found to be exclusively located in the medial septal nucleus, the diagonal band of Broca, and the nucleus basalis. This location coincided with that of cell bodies of ascending cholinergic neurons of the basal forebrain. In addition, NGF receptor-positive cells were costained for acetylcholinesterase. These findings indicate that cholinergic neurons of the basal forebrain but none of the other neurons located in this area express receptors for NGF. Results suggest that NGF acts as a trophic factor for cholinergic neurons in the human brain in a similar way as has been established in recent years for the rat brain.
| Original language | English |
|---|---|
| Pages (from-to) | 37-41 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 69 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 15 1986 |
| Externally published | Yes |
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Keywords
- Alzheimer's disease
- cholinergic neuron
- nerve growth factor
- nucleus basalis
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain. / Hefti, Franz; Hartikka, Jukka; Salvatierra, Ana; Weiner, William J.; Mash, Deborah C.
In: Neuroscience Letters, Vol. 69, No. 1, 15.08.1986, p. 37-41.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain
AU - Hefti, Franz
AU - Hartikka, Jukka
AU - Salvatierra, Ana
AU - Weiner, William J.
AU - Mash, Deborah C
PY - 1986/8/15
Y1 - 1986/8/15
N2 - Nerve growth factor (NGF) receptors were visualized in the basal human forebrain using an immunohistochemial procedure with a monoclonal antibody previously shown to recognize human melanoma cell NGF receptors. The receptors were found to be exclusively located in the medial septal nucleus, the diagonal band of Broca, and the nucleus basalis. This location coincided with that of cell bodies of ascending cholinergic neurons of the basal forebrain. In addition, NGF receptor-positive cells were costained for acetylcholinesterase. These findings indicate that cholinergic neurons of the basal forebrain but none of the other neurons located in this area express receptors for NGF. Results suggest that NGF acts as a trophic factor for cholinergic neurons in the human brain in a similar way as has been established in recent years for the rat brain.
AB - Nerve growth factor (NGF) receptors were visualized in the basal human forebrain using an immunohistochemial procedure with a monoclonal antibody previously shown to recognize human melanoma cell NGF receptors. The receptors were found to be exclusively located in the medial septal nucleus, the diagonal band of Broca, and the nucleus basalis. This location coincided with that of cell bodies of ascending cholinergic neurons of the basal forebrain. In addition, NGF receptor-positive cells were costained for acetylcholinesterase. These findings indicate that cholinergic neurons of the basal forebrain but none of the other neurons located in this area express receptors for NGF. Results suggest that NGF acts as a trophic factor for cholinergic neurons in the human brain in a similar way as has been established in recent years for the rat brain.
KW - Alzheimer's disease
KW - cholinergic neuron
KW - nerve growth factor
KW - nucleus basalis
UR - http://www.scopus.com/inward/record.url?scp=0022547630&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022547630&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(86)90410-6
DO - 10.1016/0304-3940(86)90410-6
M3 - Article
VL - 69
SP - 37
EP - 41
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -