Localization of muscarinic receptor subtypes in brain stem areas regulating sleep

H. A. Baghdoyan, V. J. Mallios, R. B. Duckrow, Deborah C Mash

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Muscarinic cholinergic receptors (mAChRs) within the pontine brain stem play a key role in generating rapid eye movement (REM) sleep. Using an in vitro autoradiographic technique that permits selective labeling of mAChR subtypes by radioligand binding, this study provides the first quantitative map of mAChR subtypes in cat brain stem areas important for REM sleep generation. M1, M2 and M3 mAChR subtypes were distributed heterogeneously throughout the brain stem. For all 3 mAChR subtypes, the greatest levels of binding were found in the dorsal raphe and locus coeruleus, and the least amount of binding was in the reticular formation. These findings are consistent with data from in vivo studies showing that multiple mAChR subtypes are involved in REM sleep generation.

Original languageEnglish
Pages (from-to)1631-1634
Number of pages4
JournalNeuroReport
Volume5
Issue number13
StatePublished - Jan 1 1994

Fingerprint

REM Sleep
Muscarinic Receptors
Brain Stem
Sleep
Reticular Formation
Locus Coeruleus
Cholinergic Receptors
Cats

Keywords

  • Dorsal raphe
  • Gigantocellular tegmental field
  • Laterodorsal tegmental nucleus
  • Locus coeruleus
  • Pedunculopontine tegmental nucleus
  • Quantitative autoradiography
  • Rapid eye movement (REM) sleep
  • Reticular formation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Baghdoyan, H. A., Mallios, V. J., Duckrow, R. B., & Mash, D. C. (1994). Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. NeuroReport, 5(13), 1631-1634.

Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. / Baghdoyan, H. A.; Mallios, V. J.; Duckrow, R. B.; Mash, Deborah C.

In: NeuroReport, Vol. 5, No. 13, 01.01.1994, p. 1631-1634.

Research output: Contribution to journalArticle

Baghdoyan, HA, Mallios, VJ, Duckrow, RB & Mash, DC 1994, 'Localization of muscarinic receptor subtypes in brain stem areas regulating sleep', NeuroReport, vol. 5, no. 13, pp. 1631-1634.
Baghdoyan HA, Mallios VJ, Duckrow RB, Mash DC. Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. NeuroReport. 1994 Jan 1;5(13):1631-1634.
Baghdoyan, H. A. ; Mallios, V. J. ; Duckrow, R. B. ; Mash, Deborah C. / Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. In: NeuroReport. 1994 ; Vol. 5, No. 13. pp. 1631-1634.
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