Localization of c-fos protein in the rat spinal cord after carrageenan treatment

Stanislava Jergová, Dáša Čí̌zková, Judita Orendáčová, Milan Čížek, Jozef Maršala

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We have characterized segmental and laminar distribution patterns of Fos-immunopositive (Fos-IP) neurons in spinal cord segments L3-L6 after carrageenan treatment. A large number of Fos-IP neurons was found in the medial region of the ipsilateral dorsal horn laminae I-II at 4 and 6 h postinjection (pi). At one day pi, the number of Fos-IP neurons was decreased significantly, which correlated with suppression of inflammation in the affected hind paw. Bilaterally, Fos-IP neurons reappeared in the L3-L6 spinal cord segments at 3-4 days pi, mainly in the deep laminae LV-LVI. However, signs of inflammation had distinctly attenuated. Our data indicate a biphasic trend in Fos-IP in this experimental model of inflammation.

Original languageEnglish (US)
Pages (from-to)381-385
Number of pages5
JournalActa Histochemica
Issue number4
StatePublished - 2002
Externally publishedYes


  • c-Fos protein
  • Carrageenan
  • Inflammation
  • Spinal cord

ASJC Scopus subject areas

  • Histology
  • Cell Biology


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