Local integration of commercially available intra-operative MR-scanner and neurosurgical guidance for metalloporphyrin-guided tumor resection and photodynamic therapy

David Dean, Jeffrey Duerk, Michael Wendt, Andrew Metzger, Lothar Lilge, Brian Wilson, Victor Yang, Warren Selman, Jonathan Lewin, Robert Ratcheson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We have locally integrated a commercial intra-operative MR-scanner and neurosurgical guidance system in order to conduct a clinical trial testing for improvement in glioma resection following administration of either of two metalloporphyrin drugs, Xcytrin™ or Lutrin™ (Pharmacyclics Inc., Sunnyvale, CA). Like other porphyrins, these two drugs have been shown to bind preferentially to tumor. The metal in Xcytrin is gadolinium. It should enhance intra-operative MR-scans taken during tumor resection. This would overcome problems of non-specific MR-enhancement caused by intra-operative contrast leakage from the vascular compartment. Both drugs provide fluorescence contrast in the presence of 450 nm wavelength light. Intra-operative fluorescence contrast should facilitate Lutrin photodynamic therapy administration to otherwise invisible glioma residual in the walls of the resection cavity. The metal in Lutrin is Lutetium. When illuminated with 732nm wavelength light, Lutrin causes tumor death via release of singlet oxygen (i.e., photodynamic therapy).

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2000 - 3rd International Conference, Proceedings
EditorsScott L. Delp, Anthony M. DiGoia, Branislav Jaramaz
PublisherSpringer Verlag
Pages338-347
Number of pages10
ISBN (Print)3540411895, 9783540411895
DOIs
StatePublished - 2000
Externally publishedYes
Event3rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2000 - Pittsburgh, United States
Duration: Oct 11 2000Oct 14 2000

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1935
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference3rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2000
Country/TerritoryUnited States
CityPittsburgh
Period10/11/0010/14/00

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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