Local glucose utilization in acute focal cerebral ischemia: Local dysmetabolism and diaschisis

Myron Ginsberg, M. Reivich, A. Giandomenico, J. H. Greenberg

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

By means of an autoradiographic technique employing 14C-2-deoxyglucose, abnormalities of local brain glucose utilization were studied 90 min following occlusion of the left middle cerebral and common carotid arteries in a series of pentobarbital-anesthetized cats. In animals with vascular occlusion, a zone of greatly suppressed glucose utilization occupied the caudate nucleus of the ischemic hemisphere, with variable extension, and was surrounded by a narrow rim of increased local brain glucose utilization, suggesting the occurrence of enhanced anaerobic glycolysis in the latter zones. The cerebral cortex, which was less constantly affected, showed alternating regions of increased and decreased glucose utilization. Quantitation of local brain glucose utilization values from the contralateral nonischemic hemisphere revealed a mild suppression of cortical glucose utilization relative to the control animals. This may be the metabolic equivalent of diaschisis.

Original languageEnglish
Pages (from-to)1042-1048
Number of pages7
JournalNeurology
Volume27
Issue number11
StatePublished - Dec 1 1977
Externally publishedYes

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Brain Ischemia
Glucose
Brain
Metabolic Equivalent
Caudate Nucleus
Common Carotid Artery
Deoxyglucose
Glycolysis
Pentobarbital
Cerebral Cortex
Blood Vessels
Cats

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ginsberg, M., Reivich, M., Giandomenico, A., & Greenberg, J. H. (1977). Local glucose utilization in acute focal cerebral ischemia: Local dysmetabolism and diaschisis. Neurology, 27(11), 1042-1048.

Local glucose utilization in acute focal cerebral ischemia : Local dysmetabolism and diaschisis. / Ginsberg, Myron; Reivich, M.; Giandomenico, A.; Greenberg, J. H.

In: Neurology, Vol. 27, No. 11, 01.12.1977, p. 1042-1048.

Research output: Contribution to journalArticle

Ginsberg, M, Reivich, M, Giandomenico, A & Greenberg, JH 1977, 'Local glucose utilization in acute focal cerebral ischemia: Local dysmetabolism and diaschisis', Neurology, vol. 27, no. 11, pp. 1042-1048.
Ginsberg, Myron ; Reivich, M. ; Giandomenico, A. ; Greenberg, J. H. / Local glucose utilization in acute focal cerebral ischemia : Local dysmetabolism and diaschisis. In: Neurology. 1977 ; Vol. 27, No. 11. pp. 1042-1048.
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