Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization

Omer Trivizki, Eric M. Moult, Liang Wang, Prashanth Iyer, Yingying Shi, Giovanni Gregori, William Feuer, James G. Fujimoto, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE. The local growth rates of geographic atrophy (GA) adjacent to non-exudative type 1 macular neovascularization (MNV) were investigated to determine if MNV influenced GA growth. METHODS. Eyes with GA and non-exudative type 1 MNV were followed for at least 1 year. Both GA and the MNV were imaged and measured using swept-source optical coherence tomography angiography (SS-OCTA) scans. Pearson correlations were computed between local growth rates of GA, which were estimated using a biophysical GA growth model, and local distances-to-MNV. Corresponding P values for the null hypothesis of no Pearson correlation were computed using a Monte Carlo approach that adjusts for spatial autocorrelations. RESULTS. Nine eyes were included in this study. There were positive correlations (Pearson's r > 0) between distance-to-MNV and local GA growth in eight (89%) of the eyes; however, in all but one eye (11%), correlations were relatively weak and statistically nonsignificant after Bonferroni correction (corrected P > 0.05). CONCLUSIONS. SS-OCTA imaging combined with GA growth modeling and spatial statistical analysis enabled quantitative assessment of correlations between local GA growth rates and local distances-to-MNV. Our results are not consistent with non-exudative type 1 MNV having a strong inhibitory effect on local GA growth rates.

Original languageEnglish (US)
Article number20
JournalInvestigative Ophthalmology and Visual Science
Volume63
Issue number1
DOIs
StatePublished - Jan 2022
Externally publishedYes

Keywords

  • Geographic atrophy (GA)
  • Growth rate
  • Macular neovascularization (MNV)
  • Non-exudative type 1
  • Optical coherence tomography angiography (OCTA)

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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