Abstract
Thrombus formation after intracoronary stent implantation provides a stimulus for neointimal hyperplasia and if excessive can result in stent thrombosis. We tested the hypothesis that local delivery of an antithrombin drug from a polymeric-metallic stent inhibits platelet thrombus formation. An uncoated metal slotted tube, a jellyroll slotted metal stent with an Argatroban-loaded polymeric sleeve, and a jellyroll slotted metal stent with a drug-leached polymeric sleeve were randomly deployed into the coronary arteries of eight juvenile farm swine. Platelet deposition in the stented segments was determined at 2 hr using autologous 111Indium oxime-labeled platelets. Platelet deposition was significantly less in the Argatroban- loaded stents compared to the Argatroban-leached stents (1.40 x 108 platelets/cm2 vs. 26.8 x 108 platelets/cm2; P = 0.005). When corrected for differences in the metal surface area exposed to blood, platelet deposition was significantly lower in the Argatroban-loaded stent (1.74 ± 1.95 x 108/cm2) compared to the Argatroban-leached stent (33.5 ± 39.1 x 108/cm2; P = 0.005) and the uncoated metal stent (36.2 ± 73.3 x 108/cm2; P = 0.006). In this coronary stent thrombosis model Argatroban has local antithrombotic properties when delivered with a polymer-metallic stent. Improved polymeric designs may reduce risk of thrombus deposition at the site of stent implantation.
| Original language | English |
|---|---|
| Pages (from-to) | 503-507 |
| Number of pages | 5 |
| Journal | Catheterization and Cardiovascular Interventions |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 1999 |
| Externally published | Yes |
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Keywords
- Antithrombin
- PTCA
- Thrombosis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging
Cite this
Local drug delivery of Argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model. / Kruse, Kevin R.; Crowley, James J.; Tanguay, Jean Francois; Santos, Renato M.; Millare, Debbie Sanders; Phillips, Harry R.; Zidar, James P.; Stack, Richard S.
In: Catheterization and Cardiovascular Interventions, Vol. 46, No. 4, 01.04.1999, p. 503-507.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Local drug delivery of Argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model
AU - Kruse, Kevin R.
AU - Crowley, James J.
AU - Tanguay, Jean Francois
AU - Santos, Renato M.
AU - Millare, Debbie Sanders
AU - Phillips, Harry R.
AU - Zidar, James P.
AU - Stack, Richard S.
PY - 1999/4/1
Y1 - 1999/4/1
N2 - Thrombus formation after intracoronary stent implantation provides a stimulus for neointimal hyperplasia and if excessive can result in stent thrombosis. We tested the hypothesis that local delivery of an antithrombin drug from a polymeric-metallic stent inhibits platelet thrombus formation. An uncoated metal slotted tube, a jellyroll slotted metal stent with an Argatroban-loaded polymeric sleeve, and a jellyroll slotted metal stent with a drug-leached polymeric sleeve were randomly deployed into the coronary arteries of eight juvenile farm swine. Platelet deposition in the stented segments was determined at 2 hr using autologous 111Indium oxime-labeled platelets. Platelet deposition was significantly less in the Argatroban- loaded stents compared to the Argatroban-leached stents (1.40 x 108 platelets/cm2 vs. 26.8 x 108 platelets/cm2; P = 0.005). When corrected for differences in the metal surface area exposed to blood, platelet deposition was significantly lower in the Argatroban-loaded stent (1.74 ± 1.95 x 108/cm2) compared to the Argatroban-leached stent (33.5 ± 39.1 x 108/cm2; P = 0.005) and the uncoated metal stent (36.2 ± 73.3 x 108/cm2; P = 0.006). In this coronary stent thrombosis model Argatroban has local antithrombotic properties when delivered with a polymer-metallic stent. Improved polymeric designs may reduce risk of thrombus deposition at the site of stent implantation.
AB - Thrombus formation after intracoronary stent implantation provides a stimulus for neointimal hyperplasia and if excessive can result in stent thrombosis. We tested the hypothesis that local delivery of an antithrombin drug from a polymeric-metallic stent inhibits platelet thrombus formation. An uncoated metal slotted tube, a jellyroll slotted metal stent with an Argatroban-loaded polymeric sleeve, and a jellyroll slotted metal stent with a drug-leached polymeric sleeve were randomly deployed into the coronary arteries of eight juvenile farm swine. Platelet deposition in the stented segments was determined at 2 hr using autologous 111Indium oxime-labeled platelets. Platelet deposition was significantly less in the Argatroban- loaded stents compared to the Argatroban-leached stents (1.40 x 108 platelets/cm2 vs. 26.8 x 108 platelets/cm2; P = 0.005). When corrected for differences in the metal surface area exposed to blood, platelet deposition was significantly lower in the Argatroban-loaded stent (1.74 ± 1.95 x 108/cm2) compared to the Argatroban-leached stent (33.5 ± 39.1 x 108/cm2; P = 0.005) and the uncoated metal stent (36.2 ± 73.3 x 108/cm2; P = 0.006). In this coronary stent thrombosis model Argatroban has local antithrombotic properties when delivered with a polymer-metallic stent. Improved polymeric designs may reduce risk of thrombus deposition at the site of stent implantation.
KW - Antithrombin
KW - PTCA
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=0033056775&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033056775&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1522-726X(199904)46:4<503::AID-CCD25>3.0.CO;2-3
DO - 10.1002/(SICI)1522-726X(199904)46:4<503::AID-CCD25>3.0.CO;2-3
M3 - Article
C2 - 10216025
AN - SCOPUS:0033056775
VL - 46
SP - 503
EP - 507
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
SN - 1522-1946
IS - 4
ER -