Local drug delivery of Argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model

Kevin R. Kruse, James J. Crowley, Jean Francois Tanguay, Renato M. Santos, Debbie Sanders Millare, Harry R. Phillips, James P. Zidar, Richard S. Stack

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Thrombus formation after intracoronary stent implantation provides a stimulus for neointimal hyperplasia and if excessive can result in stent thrombosis. We tested the hypothesis that local delivery of an antithrombin drug from a polymeric-metallic stent inhibits platelet thrombus formation. An uncoated metal slotted tube, a jellyroll slotted metal stent with an Argatroban-loaded polymeric sleeve, and a jellyroll slotted metal stent with a drug-leached polymeric sleeve were randomly deployed into the coronary arteries of eight juvenile farm swine. Platelet deposition in the stented segments was determined at 2 hr using autologous 111Indium oxime-labeled platelets. Platelet deposition was significantly less in the Argatroban- loaded stents compared to the Argatroban-leached stents (1.40 x 108 platelets/cm2 vs. 26.8 x 108 platelets/cm2; P = 0.005). When corrected for differences in the metal surface area exposed to blood, platelet deposition was significantly lower in the Argatroban-loaded stent (1.74 ± 1.95 x 108/cm2) compared to the Argatroban-leached stent (33.5 ± 39.1 x 108/cm2; P = 0.005) and the uncoated metal stent (36.2 ± 73.3 x 108/cm2; P = 0.006). In this coronary stent thrombosis model Argatroban has local antithrombotic properties when delivered with a polymer-metallic stent. Improved polymeric designs may reduce risk of thrombus deposition at the site of stent implantation.

Original languageEnglish (US)
Pages (from-to)503-507
Number of pages5
JournalCatheterization and Cardiovascular Interventions
Volume46
Issue number4
DOIs
StatePublished - Apr 1999

Keywords

  • Antithrombin
  • PTCA
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Local drug delivery of Argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model'. Together they form a unique fingerprint.

  • Cite this