Local drug delivery of Argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model

Kevin R. Kruse, James J. Crowley, Jean Francois Tanguay, Renato M. Santos, Debbie Sanders Millare, Harry R. Phillips, James P. Zidar, Richard S. Stack

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Thrombus formation after intracoronary stent implantation provides a stimulus for neointimal hyperplasia and if excessive can result in stent thrombosis. We tested the hypothesis that local delivery of an antithrombin drug from a polymeric-metallic stent inhibits platelet thrombus formation. An uncoated metal slotted tube, a jellyroll slotted metal stent with an Argatroban-loaded polymeric sleeve, and a jellyroll slotted metal stent with a drug-leached polymeric sleeve were randomly deployed into the coronary arteries of eight juvenile farm swine. Platelet deposition in the stented segments was determined at 2 hr using autologous 111Indium oxime-labeled platelets. Platelet deposition was significantly less in the Argatroban- loaded stents compared to the Argatroban-leached stents (1.40 x 108 platelets/cm2 vs. 26.8 x 108 platelets/cm2; P = 0.005). When corrected for differences in the metal surface area exposed to blood, platelet deposition was significantly lower in the Argatroban-loaded stent (1.74 ± 1.95 x 108/cm2) compared to the Argatroban-leached stent (33.5 ± 39.1 x 108/cm2; P = 0.005) and the uncoated metal stent (36.2 ± 73.3 x 108/cm2; P = 0.006). In this coronary stent thrombosis model Argatroban has local antithrombotic properties when delivered with a polymer-metallic stent. Improved polymeric designs may reduce risk of thrombus deposition at the site of stent implantation.

Original languageEnglish
Pages (from-to)503-507
Number of pages5
JournalCatheterization and Cardiovascular Interventions
Volume46
Issue number4
DOIs
StatePublished - Apr 1 1999
Externally publishedYes

Fingerprint

Stents
Swine
Blood Platelets
Pharmaceutical Preparations
Metals
Thrombosis
argatroban
Coronary Thrombosis
Oximes
Antithrombins
Hyperplasia
Coronary Vessels
Polymers

Keywords

  • Antithrombin
  • PTCA
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Local drug delivery of Argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model. / Kruse, Kevin R.; Crowley, James J.; Tanguay, Jean Francois; Santos, Renato M.; Millare, Debbie Sanders; Phillips, Harry R.; Zidar, James P.; Stack, Richard S.

In: Catheterization and Cardiovascular Interventions, Vol. 46, No. 4, 01.04.1999, p. 503-507.

Research output: Contribution to journalArticle

Kruse, Kevin R. ; Crowley, James J. ; Tanguay, Jean Francois ; Santos, Renato M. ; Millare, Debbie Sanders ; Phillips, Harry R. ; Zidar, James P. ; Stack, Richard S. / Local drug delivery of Argatroban from a polymeric-metallic composite stent reduces platelet deposition in a swine coronary model. In: Catheterization and Cardiovascular Interventions. 1999 ; Vol. 46, No. 4. pp. 503-507.
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