LnCeVar: a comprehensive database of genomic variations that disturb ceRNA network regulation

Peng Wang, Xin Li, Yue Gao, Qiuyan Guo, Shangwei Ning, Yunpeng Zhang, Shipeng Shang, Junwei Wang, Yanxia Wang, Hui Zhi, Ying Fang, Weitao Shen, Guangmei Zhang, Steven Xi Chen, Xia Li

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

LnCeVar (http://www.bio-bigdata.net/LnCeVar/) is a comprehensive database that aims to provide genomic variations that disturb lncRNA-associated competing endogenous RNA (ceRNA) network regulation curated from the published literature and high-throughput data sets. LnCeVar curated 119 501 variation-ceRNA events from thousands of samples and cell lines, including: (i) more than 2000 experimentally supported circulating, drug-resistant and prognosis-related lncRNA biomarkers; (ii) 11 418 somatic mutation-ceRNA events from TCGA and COSMIC; (iii) 112 674 CNV-ceRNA events from TCGA; (iv) 67 066 SNP-ceRNA events from the 1000 Genomes Project. LnCeVar provides a user-friendly searching and browsing interface. In addition, as an important supplement of the database, several flexible tools have been developed to aid retrieval and analysis of the data. The LnCeVar-BLAST interface is a convenient way for users to search ceRNAs by interesting sequences. LnCeVar-Function is a tool for performing functional enrichment analysis. LnCeVar-Hallmark identifies dysregulated cancer hallmarks of variation-ceRNA events. LnCeVar-Survival performs COX regression analyses and produces survival curves for variation-ceRNA events. LnCeVar-Network identifies and creates a visualization of dysregulated variation-ceRNA networks. Collectively, LnCeVar will serve as an important resource for investigating the functions and mechanisms of personalized genomic variations that disturb ceRNA network regulation in human diseases.

Original languageEnglish (US)
Pages (from-to)D111-D117
JournalNucleic acids research
Volume48
Issue numberD1
DOIs
StatePublished - Jan 8 2020

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'LnCeVar: a comprehensive database of genomic variations that disturb ceRNA network regulation'. Together they form a unique fingerprint.

Cite this