Liver transplantation with preservation of the inferior vena cava: Lessons learned through 2,000 cases

David M. Levi, Nikolaos Pararas, Andreas G. Tzakis, Seigo Nishida, Panagiotis Tryphonopoulos, Ignacio Gonzalez-Pinto, Akin Tekin, Gennaro Selvaggi, Alan Livingstone

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: We aim to demonstrate the utility and efficacy of the "piggyback technique" (PBT); liver transplant (LT) with caval preservation. Study Design: Adult LTs were performed with intent to use the PBT except in cases of juxtacaval malignancy or technical difficulty. Hepatic venous outflow was established between the donor suprahepatic cava and the joined ostia of all recipient suprahepatic veins. Technical variants with the donor cava and recipient retrohepatic cava were used as needed. The experience was divided into 2 eras: E1 (1994-2002), E2 (2002-2010). Results: We completed 945 of 1080 LTs in E1 (87.5%) and 851 of 920 LTs in E2 (92.5%) using the PBT. Thirty day mortality was 4.6% in E1, 3% in E2 (p = 0.02) with 2 intra-operative deaths in E1. One, 3, 5 year patient survival was 83.7, 75.6, 69.3% in E1 vs. 86, 78.4, 73.8% in E2 (p = 0.057). Graft survival was 77.7, 69, 62.3% in E1 vs. 84, 76.2, 71.2% in E2 (p < 0.0001). Median operative time and hospital length of stay improved in E2 (p < 0.0001, 0.0001). Outflow variants were used more frequently in E2 (11.3% vs. 6.1%). Nine patients (0.5%) developed outflow obstruction, 6 in E1, and 3 in E2. Twice, it was recognized and corrected intraoperatively. Seven patients presented with refractory ascites. Six were successfully treated (4 balloon dilatation, 2 surgical revision), one patient died after attempted dilatation. Conclusions: The PBT can be used as the preferred technique in adult LT. With experience, the technique was used more frequently, with more variants, with improved outcomes. Outflow obstruction was a rare complication.

Original languageEnglish
Pages (from-to)691-698
Number of pages8
JournalJournal of the American College of Surgeons
Volume214
Issue number4
DOIs
StatePublished - Apr 1 2012

Fingerprint

Inferior Vena Cava
Liver Transplantation
Dilatation
Liver
Length of Stay
Tissue Donors
Transplants
Venae Cavae
Graft Survival
Operative Time
Reoperation
Ascites
Veins
Survival
Mortality
Neoplasms

Keywords

  • conventional technique, hepatectomy with cava excision
  • CVT
  • E1
  • E2
  • Era 1
  • Era 2
  • inferior vena cava
  • IVC
  • liver transplant(ation)
  • LT
  • PBT
  • piggyback technique, cava preserving hepatectomy
  • temporary portocaval shunt
  • TIPS
  • TPCS
  • transjugular intrahepatic portosystemic shunt
  • venovenous bypass
  • VVBP
  • warm ischemia time
  • WIT

ASJC Scopus subject areas

  • Surgery

Cite this

Liver transplantation with preservation of the inferior vena cava : Lessons learned through 2,000 cases. / Levi, David M.; Pararas, Nikolaos; Tzakis, Andreas G.; Nishida, Seigo; Tryphonopoulos, Panagiotis; Gonzalez-Pinto, Ignacio; Tekin, Akin; Selvaggi, Gennaro; Livingstone, Alan.

In: Journal of the American College of Surgeons, Vol. 214, No. 4, 01.04.2012, p. 691-698.

Research output: Contribution to journalArticle

Levi, David M. ; Pararas, Nikolaos ; Tzakis, Andreas G. ; Nishida, Seigo ; Tryphonopoulos, Panagiotis ; Gonzalez-Pinto, Ignacio ; Tekin, Akin ; Selvaggi, Gennaro ; Livingstone, Alan. / Liver transplantation with preservation of the inferior vena cava : Lessons learned through 2,000 cases. In: Journal of the American College of Surgeons. 2012 ; Vol. 214, No. 4. pp. 691-698.
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AU - Tryphonopoulos, Panagiotis

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