Liver transplantation using elderly donors: A risk factor analysis

Dae Y. Kim, Jang Moon, Eddie R. Island, Akin Tekin, Susan Ganz, David Levi, Gennaro Selvaggi, Seigo Nishida, Andreas G. Tzakis

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Survival after liver transplantation is negatively impacted by use of elderly deceased donors, but excluding them would increase waiting times and waiting list mortality. We reviewed our experience with liver transplantation (LT) utilizing livers from deceased donors 65yr of age and older to identify those factors that impact graft survival. All adult patients (≥18yr old) who underwent primary LT using deceased donor livers from donors aged ≥65yr between February 1995 and November 2003 were included. With multivariate analysis we found four unfavorable characteristics significantly associated with higher post-transplant graft failure rate. These characteristics are hepatitis C as an etiology of liver disease, Model for End-Stage Liver Disease score >20, serum glucose level of donor >200mg/dL at the time of liver recovery, and skin incision to aortic cross-clamp time >40minutes in the donor surgery. The five-yr estimated graft survival rates having 0, 1, 2, 3, and 4 unfavorable characteristics were 100%, 82.0%, 81.7%, 39.3%, and 25.0%, respectively (p<0.05). Our data demonstrated good graft survival can be achieved in LT using elderly donor liver allografts with appropriate patient selection, donor blood glucose management and efficient liver recovery with minimal manipulation of the liver during donor surgery.

Original languageEnglish (US)
Pages (from-to)270-276
Number of pages7
JournalClinical Transplantation
Volume25
Issue number2
DOIs
StatePublished - Mar 2011

Keywords

  • Elderly donor
  • Expanded criteria
  • Liver transplantation
  • Risk factor
  • Survival

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Liver transplantation using elderly donors: A risk factor analysis'. Together they form a unique fingerprint.

  • Cite this

    Kim, D. Y., Moon, J., Island, E. R., Tekin, A., Ganz, S., Levi, D., Selvaggi, G., Nishida, S., & Tzakis, A. G. (2011). Liver transplantation using elderly donors: A risk factor analysis. Clinical Transplantation, 25(2), 270-276. https://doi.org/10.1111/j.1399-0012.2010.01222.x