Liver transplantation for decompensated cirrhosis after jejunoileal bypass

Jay S. Markowitz, Philip Seu, John A. Goss, Hasan Yersiz, James F. Markmann, Douglas G. Farmer, R. Mark Ghobrial, Leonard I. Goldstein, Paul Martin, Risë Stribling, Ronald W. Busuttil

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. Although jejunoileal bypass results in end-stage liver disease in up to 10% of patients, little is known about outcome after liver transplantation. Methods. The clinical courses of six patients who underwent liver transplantation at UCLA for decompensated cirrhosis owing to a jejunoileal bypass were reviewed. Liver function, allograft pathology, renal function, and nutritional status were assessed. Results. Of the four patients with an intact jejunoileal bypass, two of the three who were biopsied had recurrent steatotic liver disease. The two patients whose jejunoileal bypass was reversed at the time of liver transplantation had lower alkaline phosphatase, lower creatinine, higher albumin, and higher cholesterol, and were more obese than their counterparts with intact bypasses. Conclusions. Patients undergoing liver transplantation for jejunoileal bypass-associated liver disease should, if possible, have their bypass reversed at the time of transplantation; otherwise, they must be followed closely and be biopsied routinely. Reccurent liver disease should prompt reversal of the jejunoileal bypass.

Original languageEnglish
Pages (from-to)570-572
Number of pages3
JournalTransplantation
Volume65
Issue number4
DOIs
StatePublished - Feb 27 1998
Externally publishedYes

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Jejunoileal Bypass
Liver Transplantation
Fibrosis
Liver Diseases
End Stage Liver Disease
Nutritional Status
Allografts
Alkaline Phosphatase
Albumins
Creatinine
Transplantation
Cholesterol
Pathology
Kidney
Liver

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Markowitz, J. S., Seu, P., Goss, J. A., Yersiz, H., Markmann, J. F., Farmer, D. G., ... Busuttil, R. W. (1998). Liver transplantation for decompensated cirrhosis after jejunoileal bypass. Transplantation, 65(4), 570-572. https://doi.org/10.1097/00007890-199802270-00019

Liver transplantation for decompensated cirrhosis after jejunoileal bypass. / Markowitz, Jay S.; Seu, Philip; Goss, John A.; Yersiz, Hasan; Markmann, James F.; Farmer, Douglas G.; Ghobrial, R. Mark; Goldstein, Leonard I.; Martin, Paul; Stribling, Risë; Busuttil, Ronald W.

In: Transplantation, Vol. 65, No. 4, 27.02.1998, p. 570-572.

Research output: Contribution to journalArticle

Markowitz, JS, Seu, P, Goss, JA, Yersiz, H, Markmann, JF, Farmer, DG, Ghobrial, RM, Goldstein, LI, Martin, P, Stribling, R & Busuttil, RW 1998, 'Liver transplantation for decompensated cirrhosis after jejunoileal bypass', Transplantation, vol. 65, no. 4, pp. 570-572. https://doi.org/10.1097/00007890-199802270-00019
Markowitz JS, Seu P, Goss JA, Yersiz H, Markmann JF, Farmer DG et al. Liver transplantation for decompensated cirrhosis after jejunoileal bypass. Transplantation. 1998 Feb 27;65(4):570-572. https://doi.org/10.1097/00007890-199802270-00019
Markowitz, Jay S. ; Seu, Philip ; Goss, John A. ; Yersiz, Hasan ; Markmann, James F. ; Farmer, Douglas G. ; Ghobrial, R. Mark ; Goldstein, Leonard I. ; Martin, Paul ; Stribling, Risë ; Busuttil, Ronald W. / Liver transplantation for decompensated cirrhosis after jejunoileal bypass. In: Transplantation. 1998 ; Vol. 65, No. 4. pp. 570-572.
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