Liver transplantation for decompensated cirrhosis after jejunoileal bypass

Jay S. Markowitz, Philip Seu, John A. Goss, Hasan Yersiz, James F. Markmann, Douglas G. Farmer, R. Mark Ghobrial, Leonard I. Goldstein, Paul Martin, Risë Stribling, Ronald W. Busuttil

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background. Although jejunoileal bypass results in end-stage liver disease in up to 10% of patients, little is known about outcome after liver transplantation. Methods. The clinical courses of six patients who underwent liver transplantation at UCLA for decompensated cirrhosis owing to a jejunoileal bypass were reviewed. Liver function, allograft pathology, renal function, and nutritional status were assessed. Results. Of the four patients with an intact jejunoileal bypass, two of the three who were biopsied had recurrent steatotic liver disease. The two patients whose jejunoileal bypass was reversed at the time of liver transplantation had lower alkaline phosphatase, lower creatinine, higher albumin, and higher cholesterol, and were more obese than their counterparts with intact bypasses. Conclusions. Patients undergoing liver transplantation for jejunoileal bypass-associated liver disease should, if possible, have their bypass reversed at the time of transplantation; otherwise, they must be followed closely and be biopsied routinely. Reccurent liver disease should prompt reversal of the jejunoileal bypass.

Original languageEnglish (US)
Pages (from-to)570-572
Number of pages3
JournalTransplantation
Volume65
Issue number4
DOIs
StatePublished - Feb 27 1998
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

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    Markowitz, J. S., Seu, P., Goss, J. A., Yersiz, H., Markmann, J. F., Farmer, D. G., Ghobrial, R. M., Goldstein, L. I., Martin, P., Stribling, R., & Busuttil, R. W. (1998). Liver transplantation for decompensated cirrhosis after jejunoileal bypass. Transplantation, 65(4), 570-572. https://doi.org/10.1097/00007890-199802270-00019