Liver Transplant for Cholestatic Liver Diseases

Andres F. Carrion, Kalyan Ram Bhamidimarri

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Cholestatic liver diseases include a group of diverse disorders with different epidemiology, pathophysiology, clinical course, and prognosis. Despite significant advances in the clinical care of patients with cholestatic liver diseases, liver transplant (LT) remains the only definitive therapy for end-stage liver disease, regardless of the underlying cause. As per the United Network for Organ Sharing database, the rate of cadaveric LT for cholestatic liver disease was 18% in 1991, 10% in 2000, and 7.8% in 2008. This review summarizes the available evidence on various common and rare cholestatic liver diseases, disease-specific issues, and pertinent aspects of LT.

Original languageEnglish (US)
Pages (from-to)345-359
Number of pages15
JournalClinics in liver disease
Volume17
Issue number2
DOIs
StatePublished - May 1 2013

Keywords

  • Cholestatic liver disease
  • Liver transplantation
  • Outcomes
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis
  • Recurrence

ASJC Scopus subject areas

  • Hepatology

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