Liver glycogen bodies: Ground-glass hepatocytes in transplanted patients

Pablo A Bejarano, Monica T. Garcia, Maria M. Rodriguez, Phillip Ruiz, Andreas G. Tzakis

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Ground-glass hepatocytes have been described in Lafora's disease, fibrinogen deposition, hepatitis B, type IV glycogenosis, and alcohol aversion (cyanamide) therapy. We encountered ground-glass hepatocytes with intracytoplasmic inclusions in four liver biopsies from three transplanted patients who had none of the above-mentioned underlying diseases. One patient was a 4-year-old boy who had a kidney transplant for severe ureterovesical reflux. Patient 2 was a 52-year-old man who had two liver transplants because of hepatitis C. The third patient was a 7-month-old girl who underwent a multivisceral transplant because of necrotizing enterocolitis and liver failure induced by total parenteral nutrition. The patients developed liver abnormalities from 45 days to 4 years after their transplants. The livers showed conspicuous ground-glass hepatocytes in 90% of the children's samples and 30% of the adult liver cells. The cytoplasmic bodies stained strongly for Gomori methenamine-silver; they were positive for periodic acid-Schiff without diastase, but negative after diastase digestion. They were negative for colloidal iron and hepatitis B core and surface antigens. Electron microscopy revealed non-membrane bound aggregates of glycogen. Idiopathic ground-glass hepatocytes occur in transplanted patients and represent accumulation of altered glycogen. However, their clinical significance and cause are not entirely elucidated.

Original languageEnglish (US)
Pages (from-to)539-545
Number of pages7
JournalVirchows Archiv
Volume449
Issue number5
DOIs
StatePublished - Nov 1 2006

Keywords

  • Glycogen
  • Ground-glass hepatocytes
  • Inclusions

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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