Liver failure due to relapsed myeloma and hepatic iron overload

Chakra P. Chaulagain, Adalberto Gonzalez, Isaac Goldszer, Luis Caraballo, James E. Hoffman, Leah Elson, Maria Julia Diacovo

Research output: Contribution to journalArticlepeer-review


Multiple myeloma is a hematologic malignancy that classically manifests with hypercalcaemia, renal insufficiency, anaemia and lytic bone lesions. Liver dysfunction in multiple myeloma is a lesser known complication that occurs through biliary obstruction, liver infiltration by plasma cells, amyloid/light chain deposition or due to liver injury from medications. Although transfusion-related hepatic iron overload—leading to significant liver disease—is a recognised complication in certain hematologic malignancies, little is known about transfusional iron overload in patients with multiple myeloma. We present a case of a 49-year-old female with relapsed/refractory multiple myeloma who presented with rapid onset liver failure, due to both iron deposition and malignant plasma cell infiltration of the liver as a terminal event. A review of the literature on hepatic complications in multiple myeloma patients is presented.

Original languageEnglish (US)
Article number1028
StatePublished - Apr 30 2020


  • Iron overload
  • Liver dysfunction
  • Liver failure
  • Multiple myeloma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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