Liver disease in children with cystic fibrosis: A sono-biochemical comparison in 195 patients

H. Patriquin, C. Lenaerts, L. Smith, G. Perreault, A. Grignon, D. Filiatrault, J. Boisvert

Research output: Contribution to journalArticlepeer-review


Biliary cirrhosis complicating cystic fibrosis (CF) is often clinically silent. Sonography is being used to screen affected children. We wished to determine if abnormal liver architecture at sonography is related to abnormal function as measured by biochemical tests. Liver size and architecture, signs of portal hypertension (PHT), as well as serum transaminases (AST ALT) and glutamyl transferase (ΥGT) were evaluated on the same day. Of 195 children (112 boys and 83 girls, mean age 8.5 years), 38 with abnormal liver sonograms had a higher incidence of functional abnormalities than those with normal architecture (63% vs 10%, p<0.0001). The commonest abnormalities associated with abnormal function were signs of HTP (100%), of cirrhosis (high attenuation, nodules) (77%), and of steatosis (hyperechogenic livers) (50%). There is a correlation between sonographically abnormal liver architecture (especially signs of HTP and cirrhosis) and 3 tests of liver function (ΥGT, AST, and ALT). Together, these tests may be appropriate for screening children with CF for liver disease.

Original languageEnglish (US)
Pages (from-to)PEO 5008
JournalUltrasound in Medicine and Biology
Issue numberSuppl 1
StatePublished - 1997

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics


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