Liver biopsy interpretation for causes of late liver allograft dysfunction

Banff Working Group

Research output: Contribution to journalReview article

234 Scopus citations

Abstract

Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury. In an attempt to enable centers to compare and pool results, improve therapy, and better understand pathophysiological disease mechanisms, the Banff Working Group on Liver Allograft Pathology herein proposes a set of consensus criteria for the most common and problematic causes of late liver allograft dysfunction, including late-onset acute and chronic rejection, recurrent and new-onset viral and autoimmune hepatitis, biliary strictures, and recurrent primary biliary cirrhosis and primary sclerosing cholangitis. A discussion of differential diagnosis is also presented.

Original languageEnglish (US)
Pages (from-to)489-501
Number of pages13
JournalHepatology
Volume44
Issue number2
DOIs
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • Hepatology

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